KDM3A - lysine demethylase 3A Gene

Also Known as TSGA; JMJD1; JHDM2A; JHMD2A; JMJD1A

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55818

About KDM3A

Cytogenetic location: 2p11.2 Genomic coordinates (GRCh38): 2:86,437,044-86,492,716 (from NCBI)

This gene has 15 transcripts (splice variants), 128 orthologues and 3 paralogues. Ubiquitous expression in testis (RPKM 32.2), bone marrow (RPKM 27.1) and 25 other tissues.

Summary

This gene encodes a Zinc Finger Protein that contains a jumonji domain and may play a role in hormone-dependent transcriptional activation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]

KDM3A Products (2)

mRNA Protein Name
NM_001146688.2 NP_001140160.1 lysine-specific demethylase 3A
NM_018433.6 NP_060903.2 lysine-specific demethylase 3A

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables histone H3K9 demethylase activity IMP
IMP: Inferred from mutant phenotype
28262558 GOA
enables histone H3K9me/H3K9me2 demethylase activity IDA
IDA: Inferred from direct assay
16603237 GOA
enables iron ion binding IMP
IMP: Inferred from mutant phenotype
16603237 GOA
enables nuclear androgen receptor binding IDA
IDA: Inferred from direct assay
16603237 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25535969 GOA
Biological Process GO Annotation Evidence References Source
involved in androgen receptor signaling pathway IDA
IDA: Inferred from direct assay
16603237 GOA
involved in formaldehyde biosynthetic process IDA
IDA: Inferred from direct assay
16603237 GOA
involved in hormone-mediated signaling pathway IDA
IDA: Inferred from direct assay
16603237 GOA
involved in positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
16603237 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
16603237 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KDM3A Protein Structure

JmjC

JmjC: JmjC domain, hydroxylase (1155 - 1264)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1321 a.a.
Protein Preferred Names Protein Names

lysine-specific demethylase 3A

  • [histone H3]-dimethyl-L-lysine(9) demethylase 3A

KDM3A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
KDM3A Q9Y4C1 STAT1 Homo sapiens P42224-1
Anti Tag CoIP
25535969
Intra
KDM3A Q9Y4C1 STAT1 Homo sapiens P42224-1
Anti Bait CoIP
25535969
Intra
KDM3A Q9Y4C1 RPS6KA5 Homo sapiens O75582-1
Anti Tag CoIP
25535969
Intra
KDM3A Q9Y4C1 RPS6KA5 Homo sapiens O75582
Anti Bait CoIP
25535969
Intra
KDM3A Q9Y4C1 RPS6KA5 Homo sapiens O75582
Anti Tag CoIP
25535969
Cross: Cross-species interaction Intra: Intraspecies interaction

KDM3A Antibodies

Cat. No. Product Name Application Reactivity
HY-P84890 KDM3A Antibody (YA4587) WB, IHC-P, ELISA Human
HY-P84890A KDM3A Antibody (YA4587)(PBS only) WB, IHC-P, ELISA Human
HY-P84891 KDM3A Antibody (YA4588) WB, ICC/IF, ELISA Human
HY-P84891A KDM3A Antibody (YA4588)(PBS only) WB, ICC/IF, ELISA Human
HY-P84892 KDM3A Antibody (YA4589) ICC/IF, FC, ELISA Human
HY-P84892A KDM3A Antibody (YA4589)(PBS only) ICC/IF, FC, ELISA Human
HY-P85235 JMJD1A Antibody (YA4927) WB, ICC/IF, ELISA Human

Related Diseases

Diseases Alias
Male Infertility

  • Infertility, Male

  • Infertility Male

  • Male Sterility

  • Absolute Infertility
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-12304 IOX1 Inhibitor 99.89% Unkown
HY-168593 PROTAC KDM3 degrader-1 99.07% Unkown
HY-RS07211 KDM3A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-183618 DW-229 Degrader / Unkown
HY-RS17111 Kdm3a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23556 Kdm3a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris KDM3A VGNC VGNC:42322
Bos taurus KDM3A VGNC VGNC:30525
Rattus norvegicus KDM3A RGD RGD:708351
Mus musculus KDM3A MGD MGI:98847
Felis catus KDM3A VGNC VGNC:63070
Macaca mulatta KDM3A VGNC VGNC:73871
Others KDM3A NCBI