RBM14 - RNA binding motif protein 14 Gene

Also Known as SIP; COAA; PSP2; SYTIP1; TMEM137

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10432

About RBM14

Cytogenetic location: 11q13.2 Genomic coordinates (GRCh38): 11:66,616,630-66,629,934 (from NCBI)

This gene has 9 transcripts (splice variants), 268 orthologues and 24 paralogues. Ubiquitous expression in testis (RPKM 11.0), lymph node (RPKM 7.8) and 25 other tissues.

Summary

This gene encodes a ribonucleoprotein that functions as a general nuclear coactivator, and an RNA splicing modulator. This protein contains two RNA recognition motifs (RRM) at the N-terminus, and multiple hexapeptide repeat domain at the C-terminus that interacts with thyroid hormone receptor-binding protein (TRBP), and is required for transcription activation. Alternatively spliced transcript variants encoding different isoforms (with opposing effects on transcription) have been described for this gene. [provided by RefSeq, Oct 2011]

RBM14 Products (3)

mRNA Protein Name
NM_001198836.2 NP_001185765.1 RNA-binding protein 14 isoform 2
NM_001198837.2 NP_001185766.1 RNA-binding protein 14 isoform 3
NM_006328.4 NP_006319.1 RNA-binding protein 14 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables nuclear receptor coactivator activity IPI
IPI: Inferred from physical interaction
11443112 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
15919756 GOA
Biological Process GO Annotation Evidence References Source
involved in activation of innate immune response IDA
IDA: Inferred from direct assay
28712728 GOA
involved in centriole assembly IMP
IMP: Inferred from mutant phenotype
25385835 GOA
involved in negative regulation of centriole replication IMP
IMP: Inferred from mutant phenotype
25385835 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
11443112 GOA
involved in transcription initiation-coupled chromatin remodeling IPI
IPI: Inferred from physical interaction
11443112 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
25385835 GOA
located in nucleus IDA
IDA: Inferred from direct assay
25385835 GOA
part of transcription regulator complex IPI
IPI: Inferred from physical interaction
11443112 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RBM14 Protein Structure

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (3 - 60)

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (81 - 142)

  • 0
  • 200
  • 400
  • 600
  • 669 a.a.
Protein Preferred Names Protein Names

RNA-binding protein 14

  • RRM-containing coactivator activator/modulator

Recombinant RBM14 Proteins

Cat. No. Product Name Accession Purity
HY-P71612 RBM14 Protein, Human (His-SUMO) Q96PK6 (M1-M669) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Marginal Corneal Ulcer
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-150163 RBM14C12 99.00% Unkown
HY-N15826 RBM1-151 Substrate / Unkown
HY-RS11734 RBM14 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18681 Rbm14 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25167 Rbm14 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris RBM14 VGNC VGNC:45408
Rattus norvegicus RBM14 RGD RGD:620542
Felis catus RBM14 VGNC VGNC:64520
Mus musculus RBM14 MGD MGI:1929092
Bos taurus RBM14 VGNC VGNC:56277
Others RBM14 NCBI