Ddx1 - DEAD box helicase 1 Gene

Also Known as DBP-RB

Species: Mus musculus

Gene Type: protein coding
Gene ID: 104721

Summary

Enables double-stranded RNA binding activity. Involved in positive regulation of I-kappaB kinase/NF-kappaB signaling and positive regulation of myeloid dendritic cell cytokine production. Acts upstream of or within response to exogenous dsRNA and response to virus. Located in cytoplasmic stress granule; cytosol; and mitochondrion. Is expressed in several structures, including 1st branchial arch; cardiovascular system; central nervous system; genitourinary system; and stomach. Orthologous to human DDX1 (DEAD-box helicase 1). [provided by Alliance of Genome Resources, Apr 2022]

Ddx1 Products (1)

mRNA Protein Name
NM_134040.1 NP_598801.1 ATP-dependent RNA helicase DDX1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables double-stranded RNA binding IDA
IDA: Inferred from direct assay
21703541 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
18758164 MGI
Biological Process GO Annotation Evidence References Source
involved in positive regulation of canonical NF-kappaB signal transduction IMP
IMP: Inferred from mutant phenotype
21703541 MGI
involved in positive regulation of myeloid dendritic cell cytokine production IMP
IMP: Inferred from mutant phenotype
21703541 MGI
acts upstream of or within response to exogenous dsRNA IMP
IMP: Inferred from mutant phenotype
21703541 MGI
acts upstream of or within response to virus IMP
IMP: Inferred from mutant phenotype
21703541 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasmic stress granule IDA
IDA: Inferred from direct assay
21933836 MGI
located in cytosol IDA
IDA: Inferred from direct assay
21703541 MGI
located in mitochondrion IDA
IDA: Inferred from direct assay
21703541 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ATP-dependent RNA helicase DDX1

  • DEAD (Asp-Glu-Ala-Asp) box polypeptide 1

  • DEAD box protein 1

  • DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-116940 Sm4 Inhibitor 99.01% Unkown
HY-RS03629 DDX1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-185893 UNC11676A Inhibitor / Unkown
HY-187308 STK189682 / Unkown
HY-RS17684 Ddx1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24145 Ddx1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ddx1 NCBI NCBI:1653