TACC2 - transforming acidic coiled-coil containing protein 2 Gene

Also Known as AZU-1; ECTACC

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10579

About TACC2

Cytogenetic location: 10q26.13 Genomic coordinates (GRCh38): 10:121,989,163-122,254,542 (from NCBI)

This gene has 30 transcripts (splice variants), 199 orthologues and 2 paralogues. Broad expression in heart (RPKM 17.2), skin (RPKM 13.6) and 19 other tissues.

Summary

Transforming acidic coiled-coil proteins are a conserved family of centrosome- and microtubule-interacting proteins that are implicated in Cancer. This gene encodes a protein that concentrates at centrosomes throughout the cell cycle. This gene lies within a chromosomal region associated with tumorigenesis. Expression of this gene is induced by erythropoietin and is thought to affect the progression of breast tumors. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

TACC2 Products (8)

mRNA Protein Name
NM_001291876.2 NP_001278805.2 transforming acidic coiled-coil-containing protein 2 isoform e
NM_001291877.2 NP_001278806.2 transforming acidic coiled-coil-containing protein 2 isoform f
NM_001291878.2 NP_001278807.1 transforming acidic coiled-coil-containing protein 2 isoform g
NM_001291879.2 NP_001278808.1 transforming acidic coiled-coil-containing protein 2 isoform h
NM_006997.4 NP_008928.1 transforming acidic coiled-coil-containing protein 2 isoform d
NM_206860.3 NP_996742.1 transforming acidic coiled-coil-containing protein 2 isoform c
NM_206861.3 NP_996743.1 transforming acidic coiled-coil-containing protein 2 isoform b
NM_206862.4 NP_996744.4 transforming acidic coiled-coil-containing protein 2 isoform a

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables nuclear receptor binding IDA
IDA: Inferred from direct assay
15207008 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TACC2 Protein Structure

TACC

TACC: Transforming acidic coiled-coil-containing protein (TACC) (2742 - 2947)

  • 0
  • 500
  • 1000
  • 1500
  • 2000
  • 2500
  • 2948 a.a.
Protein Preferred Names Protein Names

transforming acidic coiled-coil-containing protein 2

  • anti zuai-1

Related Diseases

Diseases Alias
Mucinous Stomach Adenocarcinoma

  • Mucinous Adenocarcinoma Of The Stomach

  • Mucinous Gastric Adenocarcinoma
Gastric Diffuse Adenocarcinoma

  • Diffuse Gastric Adenocarcinoma

  • Carcinoma, Diffuse Type
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14140 TACC2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta TACC2 VGNC VGNC:78081
Canis familiaris TACC2 VGNC VGNC:47064
Felis catus TACC2 VGNC VGNC:65919
Rattus norvegicus TACC2 RGD RGD:1303004
Mus musculus TACC2 MGD MGI:1928899
Bos taurus TACC2 VGNC VGNC:35558
Others TACC2 NCBI