YKT6 - YKT6 v-SNARE homolog Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10652

About YKT6

Cytogenetic location: 7p13 Genomic coordinates (GRCh38): 7:44,200,978-44,214,294 (from NCBI)

This gene has 15 transcripts (splice variants), 232 orthologues and 10 paralogues. Ubiquitous expression in brain (RPKM 24.8), colon (RPKM 21.7) and 25 other tissues.

Summary

This gene product is one of the SNARE recognition molecules implicated in vesicular transport between secretory compartments. It is a membrane associated, isoprenylated protein that functions at the endoplasmic reticulum-Golgi transport step. This protein is highly conserved from yeast to human and can functionally complement the loss of the yeast homolog in the yeast secretory pathway. [provided by RefSeq, Jul 2008]

YKT6 Products (3)

mRNA	Protein	Name
NM_001363678.2	NP_001350607.1	synaptobrevin homolog YKT6 isoform 2
NM_001410874.1	NP_001397803.1	synaptobrevin homolog YKT6 isoform 3
NM_006555.4	NP_006546.1	synaptobrevin homolog YKT6 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables SNAP receptor activity	IDA IDA: Inferred from direct assay	15215310	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	33422265	GOA
enables protein-cysteine S-palmitoyltransferase activity	IDA IDA: Inferred from direct assay	15479160	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in endoplasmic reticulum to Golgi vesicle-mediated transport	IDA IDA: Inferred from direct assay	9211930	GOA
involved in retrograde transport, endosome to Golgi	IDA IDA: Inferred from direct assay	15215310	GOA
involved in vesicle docking involved in exocytosis	IDA IDA: Inferred from direct assay	9211930	GOA
involved in vesicle targeting	IDA IDA: Inferred from direct assay	9211930	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	15215310	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	25468996	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	9211930	GOA
located in endosome	IDA IDA: Inferred from direct assay	15215310	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	9211930	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

YKT6 Protein Structure

Longin

Synaptobrevin

0
100
198 a.a.

Protein Preferred Names	Protein Names
synaptobrevin homolog YKT6	R-SNARE

YKT6 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	YKT6	O15498	STX7	Homo sapiens	O15400	Anti Tag CoIP	33422265

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant YKT6 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71025	YKT6 Protein, Human (His)	O15498-1 (M1-M198)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Foodborne Botulism	Botulism Botulism Poisoning Intoxication With Clostridium Botulinum Toxin Wound Botulism Food Poisoning Due To Clostridium Botulinum Infection Due To Clostridium Botulinum Infant Botulism Intoxication Botulism Botulism, Infantile Clostridium Botulinum Poisoning Botulism Nos
Infant Botulism	Infant Intestinal Botulism Infant Intestinal Toxemia Botulism Infant Intestinal Toxin-Mediated Botulism Infantile Botulism Botulism, Infantile
Cerebral Dysgenesis, Neuropathy, Ichthyosis, And Palmoplantar Keratoderma Syndrome	Cednik Syndrome CEDNIK Cerebral Dysgenesis, Neuropathy, Ichthyosis And Keratoderma Syndrome Cerebral Dysgenesis, Neuropathy, Ichthyosis, And Palmoplantar Keratoderma Syndro Cerebral Dysgenesis-Neuropathy-Ichthyosis-Palmoplantar Keratoderma Syndrome Cerebral Dysgenesis-Neuropathy-Ichthyosis-Keratoderma Syndrome Cerebral Dysgenesis, Neuropathy, Ichthyosis, And Palmoplantar Keratoderma Neurocutaneous Syndromes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15927	YKT6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19168	Ykt6 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25657	Ykt6 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	YKT6	VGNC	VGNC:37030
Mus musculus	YKT6	MGD	MGI:1927550
Macaca mulatta	YKT6	VGNC	VGNC:81796
Felis catus	YKT6	VGNC	VGNC:67146
Rattus norvegicus	YKT6	RGD	RGD:70897
Others	YKT6	NCBI