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YKT6 Protein, Human (His)

Cat. No.: HY-P71025
COA Handling Instructions

YKT6 is a vesicle soluble NSF attachment protein receptor (v-SNARE) that mediates vesicle docking and fusion in the endoplasmic reticulum to Golgi trafficking, forming a SNARE complex with GOSR1, GOSR2, and STX5. It is also involved in the transport of early/recycling endosomes to the trans-Golgi network, forming another SNARE complex with BET1L, GOSR1 and STX5. YKT6 Protein, Human (His) is the recombinant human-derived YKT6 protein, expressed by E. coli , with N-6*His labeled tag. The total length of YKT6 Protein, Human (His) is 198 a.a., with molecular weight of ~28.0 kDa.

For research use only. We do not sell to patients.

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Description

YKT6 is a vesicle soluble NSF attachment protein receptor (v-SNARE) that mediates vesicle docking and fusion in the endoplasmic reticulum to Golgi trafficking, forming a SNARE complex with GOSR1, GOSR2, and STX5. It is also involved in the transport of early/recycling endosomes to the trans-Golgi network, forming another SNARE complex with BET1L, GOSR1 and STX5. YKT6 Protein, Human (His) is the recombinant human-derived YKT6 protein, expressed by E. coli , with N-6*His labeled tag. The total length of YKT6 Protein, Human (His) is 198 a.a., with molecular weight of ~28.0 kDa.

Background

YKT6, a vesicular soluble NSF attachment protein receptor (v-SNARE), plays a pivotal role in mediating vesicle docking and fusion with specific acceptor cellular compartments. It functions in endoplasmic reticulum to Golgi transport, contributing to a SNARE complex alongside GOSR1, GOSR2, and STX5. Additionally, YKT6 is involved in early/recycling endosome to trans-Golgi network transport, forming another SNARE complex with BET1L, GOSR1, and STX5. Beyond its role in membrane fusion events, YKT6 exhibits S-palmitoyl transferase activity, adding a layer of complexity to its functional repertoire. Identified in two distinct SNARE complexes, YKT6's involvement underscores its significance in orchestrating vesicular trafficking and membrane fusion processes within the cellular transport network.

Species

Human

Source

E. coli

Tag

N-6*His

Accession

O15498 (M1-M198)

Gene ID
Molecular Construction
N-term
6*His
YKT6 (M1-M198)
Accession # O15498
C-term
Synonyms
Synaptobrevin homolog YKT6; YKT6
AA Sequence

MKLYSLSVLYKGEAKVVLLKAAYDVSSFSFFQRSSVQEFMTFTSQLIVERSSKGTRASVKEQDYLCHVYVRNDSLAGVVIADNEYPSRVAFTLLEKVLDEFSKQVDRIDWPVGSPATIHYPALDGHLSRYQNPREADPMTKVQAELDETKIILHNTMESLLERGEKLDDLVSKSEVLGTQSKAFYKTARKQNSCCAIM

Molecular Weight

Approximately 28.0 kDa

Purity

Greater than 95% as determined by reducing SDS-PAGE.

Appearance

Solution.

Formulation

Supplied as a 0.2 μm filtered solution of 50 mM Tris, pH 8.0.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Storage & Stability

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping

Shipping with dry ice.

Documentation

YKT6 Protein, Human (His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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Product Name:
YKT6 Protein, Human (His)
Cat. No.:
HY-P71025
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