Atf5 - activating transcription factor 5 Gene

Also Known as AFTA; Atf7; Atfx; ODA-10

Species: Mus musculus

Gene Type: protein coding

Gene ID: 107503

Summary

Enables chromatin binding activity and transcription cis-regulatory region binding activity. Involved in cerebellar granule cell precursor proliferation and fat cell differentiation. Acts upstream of or within several processes, including circadian rhythm; negative regulation of apoptotic process; and olfactory bulb interneuron development. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; integumental system; sensory organ; and urinary system. Orthologous to human ATF5 (activating transcription factor 5). [provided by Alliance of Genome Resources, Apr 2022]

Atf5 Products (1)

mRNA	Protein	Name
NM_030693.2	NP_109618.1	cyclic AMP-dependent transcription factor ATF-5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables chromatin binding	IDA IDA: Inferred from direct assay	24216764	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	22974638	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	24216764	MGI
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	24216764	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in cerebellar granule cell precursor proliferation	IMP IMP: Inferred from mutant phenotype	22095825	MGI
involved in circadian rhythm	IEP IEP: Inferred from expression pattern	21768648	MGI
involved in fat cell differentiation	IMP IMP: Inferred from mutant phenotype	24216764	MGI
acts upstream of or within multicellular organism growth	IMP IMP: Inferred from mutant phenotype	23090999	MGI
acts upstream of or within negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	12130540	MGI
acts upstream of or within olfactory bulb interneuron development	IMP IMP: Inferred from mutant phenotype	23090999	MGI
acts upstream of or within olfactory bulb interneuron differentiation	IMP IMP: Inferred from mutant phenotype	23090999	MGI
acts upstream of or within olfactory lobe development	IMP IMP: Inferred from mutant phenotype	23090999	MGI
acts upstream of or within post-embryonic development	IMP IMP: Inferred from mutant phenotype	23090999	MGI
NOT acts upstream of or within regulation of cell cycle	IDA IDA: Inferred from direct assay	12130540	MGI
NOT acts upstream of or within regulation of cell population proliferation	IDA IDA: Inferred from direct assay	12130540	MGI
acts upstream of or within regulation of gene expression	IMP IMP: Inferred from mutant phenotype	23090999	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	10777215	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	22095825	MGI
part of transcription regulator complex	IDA IDA: Inferred from direct assay	10777215	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
cyclic AMP-dependent transcription factor ATF-5	BZIP protein ATF7 NAP1 NRIF3-associated protein activating transcription factor 5-alpha/beta activating transcription factor 7 activating transcription factor X cAMP-dependent transcription factor ATF-5 transcription factor ATFx transcription fact

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-112680A	Carboxy pyridostatin trifluoroacetate salt		99.49%	Unkown
HY-112680	Carboxypyridostatin		99.41%	Unkown
HY-RS19118	Atf5 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS01131	ATF5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25608	Atf5 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Atf5	NCBI	NCBI:22809