Shmt2 - serine hydroxymethyltransferase 2 (mitochondrial) Gene

Also Known as SHMT; 2700043D08Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 108037

Summary

Enables glycine hydroxymethyltransferase activity. Involved in regulation of mitochondrial translation; regulation of oxidative phosphorylation; and tetrahydrofolate interconversion. Located in nucleus. Is expressed in several structures, including brain; neural retina; placenta; skeleton; and submandibular gland primordium. Orthologous to human SHMT2 (serine hydroxymethyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]

Shmt2 Products (2)

mRNA Protein Name
NM_001252316.1 NP_001239245.1 serine hydroxymethyltransferase, mitochondrial isoform 2
NM_028230.4 NP_082506.1 serine hydroxymethyltransferase, mitochondrial isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables glycine hydroxymethyltransferase activity IGI
IGI: Inferred from genetic interaction
19513116 MGI
enables glycine hydroxymethyltransferase activity IMP
IMP: Inferred from mutant phenotype
19513116 MGI
Biological Process GO Annotation Evidence References Source
involved in regulation of aerobic respiration IMP
IMP: Inferred from mutant phenotype
29323231 MGI
involved in regulation of mitochondrial translation IMP
IMP: Inferred from mutant phenotype
29323231 MGI
involved in regulation of oxidative phosphorylation IMP
IMP: Inferred from mutant phenotype
29323231 MGI
involved in tetrahydrofolate interconversion IMP
IMP: Inferred from mutant phenotype
19513116 MGI
Cellular Component GO Annotation Evidence References Source
is active in nucleus IDA
IDA: Inferred from direct assay
19513116 MGI
is active in nucleus IGI
IGI: Inferred from genetic interaction
19513116 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

serine hydroxymethyltransferase, mitochondrial

  • glycine hydroxymethyltransferase

  • serine methylase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-182019 HDAC11-IN-5 Activator 98.25% Unkown
HY-177092 AGF347 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Shmt2 NCBI NCBI:6472