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Prkaa2 - protein kinase, AMP-activated, alpha 2 catalytic subunit Gene

Also Known as A830082D05; AMPKalpha2; 2310008I11Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 108079

Summary

Enables AMP-activated protein kinase activity; chromatin binding activity; and histone serine kinase activity. Involved in several processes, including regulation of autophagy; regulation of organelle organization; and regulation of protein modification process. Acts upstream of or within several processes, including cellular response to prostaglandin E stimulus; cellular response to xenobiotic stimulus; and response to muscle activity. Located in several cellular components, including cytoplasmic stress granule; dendrite; and neuronal cell body. Is expressed in several structures, including brain; genitourinary system; gut; lung; and spinal cord. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human PRKAA2 (protein kinase AMP-activated catalytic subunit alpha 2). [provided by Alliance of Genome Resources, Apr 2022]

Prkaa2 Products (2)

mRNA	Protein	Name
NM_001356568.1	NP_001343497.1	5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform 2
NM_178143.2	NP_835279.2	5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables AMP-activated protein kinase activity	IDA IDA: Inferred from direct assay	18439900	MGI
enables AMP-activated protein kinase activity	IGI IGI: Inferred from genetic interaction	25788287	MGI
enables AMP-activated protein kinase activity	IMP IMP: Inferred from mutant phenotype	16308421	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	20647423	MGI
enables histone H2BS36 kinase activity	IDA IDA: Inferred from direct assay	20647423	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	19833968	MGI
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	32912901	MGI
enables protein serine/threonine kinase activity	IMP IMP: Inferred from mutant phenotype	16308421	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to calcium ion	IGI IGI: Inferred from genetic interaction	25788287	MGI
involved in cellular response to glucose starvation	IDA IDA: Inferred from direct assay	21258367	MGI
involved in cellular response to glucose stimulus	IGI IGI: Inferred from genetic interaction	25788287	MGI
involved in cellular response to nutrient levels	IDA IDA: Inferred from direct assay	21258367	MGI
involved in cellular response to oxidative stress	IGI IGI: Inferred from genetic interaction	27430620	MGI
acts upstream of or within cellular response to prostaglandin E stimulus	IGI IGI: Inferred from genetic interaction	23479225	MGI
acts upstream of or within cellular response to xenobiotic stimulus	IMP IMP: Inferred from mutant phenotype	23918774	MGI
involved in glucose homeostasis	IMP IMP: Inferred from mutant phenotype	16308421	MGI
involved in lipid biosynthetic process	IDA IDA: Inferred from direct assay	21459323	MGI
involved in negative regulation of TOR signaling	IMP IMP: Inferred from mutant phenotype	18439900	MGI
involved in negative regulation of TORC1 signaling	IDA IDA: Inferred from direct assay	32912901	MGI
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	18439900	MGI
involved in negative regulation of gene expression	IGI IGI: Inferred from genetic interaction	27430620	MGI
involved in negative regulation of tubulin deacetylation	IGI IGI: Inferred from genetic interaction	27430620	MGI
involved in positive regulation of autophagy	IMP IMP: Inferred from mutant phenotype	21258367	MGI
involved in positive regulation of peptidyl-lysine acetylation	IGI IGI: Inferred from genetic interaction	27430620	MGI
involved in positive regulation of protein localization	IGI IGI: Inferred from genetic interaction	27430620	MGI
involved in protein localization to lipid droplet	IDA IDA: Inferred from direct assay	34077757	MGI
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	23332761	MGI
involved in regulation of circadian rhythm	IMP IMP: Inferred from mutant phenotype	19833968	MGI
acts upstream of or within regulation of gene expression	IMP IMP: Inferred from mutant phenotype	23918774	MGI
involved in regulation of macroautophagy	IDA IDA: Inferred from direct assay	23332761	MGI
involved in regulation of microtubule cytoskeleton organization	IGI IGI: Inferred from genetic interaction	27430620	MGI
involved in regulation of stress granule assembly	IGI IGI: Inferred from genetic interaction	27430620	MGI
acts upstream of or within response to muscle activity	IMP IMP: Inferred from mutant phenotype	23918774	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in axon	IGI IGI: Inferred from genetic interaction	25788287	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	30201684	MGI
located in cytoplasmic stress granule	IDA IDA: Inferred from direct assay	27430620	MGI
located in dendrite	IGI IGI: Inferred from genetic interaction	25788287	MGI
located in neuronal cell body	IGI IGI: Inferred from genetic interaction	25788287	MGI
located in nucleus	IDA IDA: Inferred from direct assay	10098881	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
5'-AMP-activated protein kinase catalytic subunit alpha-2	ACACA kinase AMPK subunit alpha-2 HMGCR kinase acetyl-CoA carboxylase kinase hydroxymethylglutaryl-CoA reductase kinase

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P11779	Ac-RKAA-PABC-MMAE	Inhibitor	/	Unkown
HY-P11779A	Ac-RKAA-PABC-MMAE TFA	Inhibitor	/	Unkown
HY-RS21177	Prkaa2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS11101	PRKAA2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27694	Prkaa2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Prkaa2	NCBI	NCBI:5563