PRKAA2 - protein kinase AMP-activated catalytic subunit alpha 2 Gene

Also Known as AMPK; AMPK2; PRKAA; AMPKa2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5563

About PRKAA2

Cytogenetic location: 1p32.2 Genomic coordinates (GRCh38): 1:56,645,314-56,715,335 (from NCBI)

This gene has 1 transcript (splice variant), 222 orthologues and 17 paralogues. Biased expression in heart (RPKM 14.0), kidney (RPKM 6.8) and 8 other tissues.

Summary

The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates Acetyl-CoA Carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key Enzymes involved in regulating de novo biosynthesis of fatty acid and Cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body Insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia. [provided by RefSeq, Jul 2008]

PRKAA2 Products (1)

mRNA	Protein	Name
NM_006252.4	NP_006243.2	5'-AMP-activated protein kinase catalytic subunit alpha-2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables AMP-activated protein kinase activity	IDA IDA: Inferred from direct assay	14651849	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	18439900	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	18439900	GOA
enables protein serine/threonine/tyrosine kinase activity	IDA IDA: Inferred from direct assay	22797923	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in cellular response to glucose starvation	IDA IDA: Inferred from direct assay	14651849	GOA
involved in cellular response to nutrient levels	IDA IDA: Inferred from direct assay	25412657	GOA
acts upstream of positive effect lipid droplet disassembly	IDA IDA: Inferred from direct assay	34077757	GOA
involved in negative regulation of TORC1 signaling	IDA IDA: Inferred from direct assay	14651849	GOA
involved in negative regulation of hepatocyte apoptotic process	IDA IDA: Inferred from direct assay	32029622	GOA
involved in protein localization to lipid droplet	IDA IDA: Inferred from direct assay	34077757	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
part of nucleotide-activated protein kinase complex	IPI IPI: Inferred from physical interaction	9693118	GOA
located in nucleus	IDA IDA: Inferred from direct assay	9693118	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRKAA2 Protein Structure

Pkinase

0
100
200
300
400
500
552 a.a.

Protein Preferred Names	Protein Names
5'-AMP-activated protein kinase catalytic subunit alpha-2	5'-AMP-activated protein kinase, catalytic alpha-2 chain

PRKAA2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	PRKAA2	P54646	HOMEZ	Homo sapiens	Q8IX15-3	Validated Y2H	25416956
Intra	PRKAA2	P54646	KRTAP10-9	Homo sapiens	P60411	Validated Y2H	32296183
Intra	PRKAA2	P54646	KRTAP10-9	Homo sapiens	P60411	Y2H Array	32296183
Intra	PRKAA2	P54646	KRTAP10-9	Homo sapiens	P60411	Y2H Prey Pooling	32296183
Intra	PRKAA2	P54646	NECAB2	Homo sapiens	Q7Z6G3-2	Y2H Prey Pooling	25416956
Intra	PRKAA2	P54646	NUTM1	Homo sapiens	Q86Y26	Validated Y2H	25416956
Intra	PRKAA2	P54646	CDX4	Homo sapiens	O14627	Y2H Array	32296183
Intra	PRKAA2	P54646	CDX4	Homo sapiens	O14627	Y2H Prey Pooling	32296183
Intra	PRKAA2	P54646	FOS	Homo sapiens	Q6FG41	Validated Y2H	25416956
Intra	PRKAA2	P54646	FOS	Homo sapiens	Q6FG41	Y2H Array	25416956
Intra	PRKAA2	P54646	KIF24	Homo sapiens	Q5T7B8-2	Validated Y2H	25416956
Intra	PRKAA2	P54646	KIF24	Homo sapiens	Q5T7B8-2	Y2H Prey Pooling	25416956
Intra	PRKAA2	P54646	ZNF397	Homo sapiens	Q8NF99	Y2H Prey Pooling	25416956
Intra	PRKAA2	P54646	ZNF397	Homo sapiens	Q8NF99	Validated Y2H	25416956
Intra	PRKAA2	P54646	DNAAF6	Homo sapiens	Q9NQM4	Y2H Array	32296183
Intra	PRKAA2	P54646	DNAAF6	Homo sapiens	Q9NQM4	Y2H Prey Pooling	32296183
Intra	PRKAA2	P54646	DNAAF6	Homo sapiens	Q9NQM4	Validated Y2H	32296183
Intra	PRKAA2	P54646	FNDC3B	Homo sapiens	Q53EP0-3	Y2H Prey Pooling	32296183
Intra	PRKAA2	P54646	FNDC3B	Homo sapiens	Q53EP0-3	Validated Y2H	32296183
Intra	PRKAA2	P54646	FNDC3B	Homo sapiens	Q53EP0-3	Y2H Array	32296183
Intra	PRKAA2	P54646	PRKAB2	Homo sapiens	O43741	Y2H Array	25416956
Intra	PRKAA2	P54646	PRKAB2	Homo sapiens	O43741	Pull Down	32707033
Intra	PRKAA2	P54646	PRKAB2	Homo sapiens	O43741	Y2H Prey Pooling	25416956
Intra	PRKAA2	P54646	PRKAB2	Homo sapiens	O43741	Anti Tag CoIP	20562859
Intra	PRKAA2	P54646	REL	Homo sapiens	Q04864-2	Validated Y2H	32296183
Intra	PRKAA2	P54646	REL	Homo sapiens	Q04864-2	Y2H Array	32296183
Intra	PRKAA2	P54646	REL	Homo sapiens	Q04864-2	Y2H Array	30886144
Intra	PRKAA2	P54646	REL	Homo sapiens	Q04864-2	Y2H Prey Pooling	32296183
Intra	PRKAA2	P54646	KIF16B	Homo sapiens	Q96L93-6	Validated Y2H	32296183
Intra	PRKAA2	P54646	KIF16B	Homo sapiens	Q96L93-6	Y2H Array	32296183
Intra	PRKAA2	P54646	KIF16B	Homo sapiens	Q96L93-6	Y2H Prey Pooling	32296183
Intra	PRKAA2	P54646	CDC42EP1	Homo sapiens	Q00587-2	Validated Y2H	32296183
Intra	PRKAA2	P54646	CDC42EP1	Homo sapiens	Q00587-2	Y2H Prey Pooling	32296183
Intra	PRKAA2	P54646	CDC42EP1	Homo sapiens	Q00587-2	Y2H Array	32296183
Intra	PRKAA2	P54646	ABI2	Homo sapiens	Q9NYB9-2	Y2H Array	32296183
Intra	PRKAA2	P54646	ABI2	Homo sapiens	Q9NYB9-2	Y2H Prey Pooling	32296183
Intra	PRKAA2	P54646	ABI2	Homo sapiens	Q9NYB9-2	Validated Y2H	32296183
Intra	PRKAA2	P54646	GOLGA6A	Homo sapiens	Q9NYA3	Y2H Prey Pooling	32296183
Intra	PRKAA2	P54646	GOLGA6A	Homo sapiens	Q9NYA3	Validated Y2H	32296183
Intra	PRKAA2	P54646	GOLGA6A	Homo sapiens	Q9NYA3	Y2H Array	32296183
Intra	PRKAA2	P54646	PRDM6	Homo sapiens	Q9NQX0	Y2H Prey Pooling	32296183
Intra	PRKAA2	P54646	PRDM6	Homo sapiens	Q9NQX0	Y2H Array	32296183
Intra	PRKAA2	P54646	PRDM6	Homo sapiens	Q9NQX0	Validated Y2H	32296183
Intra	PRKAA2	P54646	IKZF1	Homo sapiens	Q13422-7	Y2H Array	32296183
Intra	PRKAA2	P54646	IKZF1	Homo sapiens	Q13422-7	Y2H Prey Pooling	32296183
Intra	PRKAA2	P54646	IKZF1	Homo sapiens	Q13422-7	Validated Y2H	32296183
Intra	PRKAA2	P54646	MTUS2	Homo sapiens	Q5JR59-3	Y2H Array	30886144
Intra	PRKAA2	P54646	MTUS2	Homo sapiens	Q5JR59-3	Y2H Array	32296183
Intra	PRKAA2	P54646	MTUS2	Homo sapiens	Q5JR59-3	Y2H Prey Pooling	32296183
Intra	PRKAA2	P54646	MTUS2	Homo sapiens	Q5JR59-3	Validated Y2H	32296183
Intra	PRKAA2	P54646	USH1C	Homo sapiens	Q9Y6N9-4	Y2H Array	32296183
Intra	PRKAA2	P54646	USH1C	Homo sapiens	Q9Y6N9-4	Y2H Prey Pooling	32296183
Intra	PRKAA2	P54646	USH1C	Homo sapiens	Q9Y6N9-4	Validated Y2H	32296183
Intra	PRKAA2	P54646	CPSF7	Homo sapiens	Q8N684-3	Y2H Prey Pooling	32296183
Intra	PRKAA2	P54646	CPSF7	Homo sapiens	Q8N684-3	Validated Y2H	32296183
Intra	PRKAA2	P54646	CPSF7	Homo sapiens	Q8N684-3	Y2H Array	32296183
Intra	PRKAA2	P54646	TLE5	Homo sapiens	Q08117-2	Y2H Prey Pooling	32296183
Intra	PRKAA2	P54646	TLE5	Homo sapiens	Q08117-2	Validated Y2H	32296183
Intra	PRKAA2	P54646	TLE5	Homo sapiens	Q08117-2	Y2H Array	32296183
Intra	PRKAA2	P54646	ABI1	Homo sapiens	Q8IZP0-5	Y2H Array	32296183
Intra	PRKAA2	P54646	ABI1	Homo sapiens	Q8IZP0-5	Validated Y2H	32296183
Intra	PRKAA2	P54646	ABI1	Homo sapiens	Q8IZP0-5	Y2H Prey Pooling	32296183
Intra	PRKAA2	P54646	EMILIN1	Homo sapiens	Q9Y6C2-2	Y2H Prey Pooling	32296183
Intra	PRKAA2	P54646	EMILIN1	Homo sapiens	Q9Y6C2-2	Validated Y2H	32296183
Intra	PRKAA2	P54646	EMILIN1	Homo sapiens	Q9Y6C2-2	Y2H Array	32296183
Intra	PRKAA2	P54646	KRTAP1-3	Homo sapiens	Q8IUG1	Y2H Prey Pooling	32296183
Intra	PRKAA2	P54646	KRTAP1-3	Homo sapiens	Q8IUG1	Y2H Array	32296183
Intra	PRKAA2	P54646	CDR2	Homo sapiens	Q01850	Validated Y2H	32296183
Intra	PRKAA2	P54646	CDR2	Homo sapiens	Q01850	Y2H Array	32296183
Intra	PRKAA2	P54646	CDR2	Homo sapiens	Q01850	Y2H Prey Pooling	32296183
Intra	PRKAA2	P54646	PRKAG1	Homo sapiens	P54619	Y2H Array	31515488
Intra	PRKAA2	P54646	PRKAG1	Homo sapiens	P54619	Validated Y2H	25416956
Intra	PRKAA2	P54646	PRKAG1	Homo sapiens	P54619	Pull Down	32707033
Intra	PRKAA2	P54646	PRKAG1	Homo sapiens	P54619	Anti Tag CoIP	20562859
Intra	PRKAA2	P54646	LCN2	Homo sapiens	P80188	Y2H Array	32296183
Intra	PRKAA2	P54646	LCN2	Homo sapiens	P80188	Y2H Prey Pooling	32296183
Intra	PRKAA2	P54646	LCN2	Homo sapiens	P80188	Validated Y2H	32296183
Intra	PRKAA2	P54646	L3MBTL3	Homo sapiens	Q96JM7-2	Y2H Prey Pooling	32296183
Intra	PRKAA2	P54646	L3MBTL3	Homo sapiens	Q96JM7-2	Validated Y2H	32296183
Intra	PRKAA2	P54646	L3MBTL3	Homo sapiens	Q96JM7-2	Y2H Array	32296183
Intra	PRKAA2	P54646	SAXO4	Homo sapiens	Q7Z5V6-2	Y2H Prey Pooling	32296183
Intra	PRKAA2	P54646	SAXO4	Homo sapiens	Q7Z5V6-2	Validated Y2H	32296183
Intra	PRKAA2	P54646	SAXO4	Homo sapiens	Q7Z5V6-2	Y2H Array	32296183
Intra	PRKAA2	P54646	PLEKHN1	Homo sapiens	Q494U1-3	Y2H Prey Pooling	32296183
Intra	PRKAA2	P54646	PLEKHN1	Homo sapiens	Q494U1-3	Y2H Array	32296183
Intra	PRKAA2	P54646	PLEKHN1	Homo sapiens	Q494U1-3	Validated Y2H	32296183
Intra	PRKAA2	P54646	ZMYND12	Homo sapiens	Q9H0C1	Validated Y2H	32296183
Intra	PRKAA2	P54646	ZMYND12	Homo sapiens	Q9H0C1	Y2H Prey Pooling	32296183
Intra	PRKAA2	P54646	ZMYND12	Homo sapiens	Q9H0C1	Y2H Array	32296183
Intra	PRKAA2	P54646	EPN2	Homo sapiens	O95208-2	Y2H Prey Pooling	32296183
Intra	PRKAA2	P54646	EPN2	Homo sapiens	O95208-2	Y2H Array	32296183
Intra	PRKAA2	P54646	VPS28	Homo sapiens	Q9UK41-2	Validated Y2H	32296183
Intra	PRKAA2	P54646	VPS28	Homo sapiens	Q9UK41-2	Y2H Array	32296183
Intra	PRKAA2	P54646	VPS28	Homo sapiens	Q9UK41-2	Y2H Prey Pooling	32296183
Intra	PRKAA2	P54646	ANAPC11	Homo sapiens	Q9NYG5-2	Y2H Array	32296183
Intra	PRKAA2	P54646	ANAPC11	Homo sapiens	Q9NYG5-2	Y2H Prey Pooling	32296183
Intra	PRKAA2	P54646	ANAPC11	Homo sapiens	Q9NYG5-2	Validated Y2H	32296183
Intra	PRKAA2	P54646	SLA2	Homo sapiens	Q9H6Q3	Validated Y2H	32296183
Intra	PRKAA2	P54646	SLA2	Homo sapiens	Q9H6Q3	Y2H Prey Pooling	32296183
Intra	PRKAA2	P54646	SLA2	Homo sapiens	Q9H6Q3	Y2H Array	32296183
Intra	PRKAA2	P54646	CTAG2	Homo sapiens	O75638-2	Y2H Prey Pooling	32296183
Intra	PRKAA2	P54646	CTAG2	Homo sapiens	O75638-2	Y2H Array	32296183
Intra	PRKAA2	P54646	SOHLH1	Homo sapiens	Q5JUK2	Validated Y2H	32296183
Intra	PRKAA2	P54646	SOHLH1	Homo sapiens	Q5JUK2	Y2H Array	32296183
Intra	PRKAA2	P54646	SOHLH1	Homo sapiens	Q5JUK2	Y2H Prey Pooling	32296183
Intra	PRKAA2	P54646	ZNF212	Homo sapiens	Q9UDV6	Y2H Array	32296183
Intra	PRKAA2	P54646	ZNF212	Homo sapiens	Q9UDV6	Validated Y2H	32296183
Intra	PRKAA2	P54646	ZNF212	Homo sapiens	Q9UDV6	Y2H Prey Pooling	32296183
Intra	PRKAA2	P54646	AMOT	Homo sapiens	A2BDD9	Y2H Array	32296183
Intra	PRKAA2	P54646	AMOT	Homo sapiens	A2BDD9	Y2H Prey Pooling	32296183
Intra	PRKAA2	P54646	MYCL	Homo sapiens	P12524-2	Y2H Prey Pooling	32296183
Intra	PRKAA2	P54646	MYCL	Homo sapiens	P12524-2	Y2H Array	32296183
Intra	PRKAA2	P54646	KIFC3	Homo sapiens	Q9BVG8	Validated Y2H	25416956
Intra	PRKAA2	P54646	MKRN3	Homo sapiens	Q13064	Y2H Prey Pooling	32296183
Intra	PRKAA2	P54646	MKRN3	Homo sapiens	Q13064	Validated Y2H	32296183
Intra	PRKAA2	P54646	MKRN3	Homo sapiens	Q13064	Y2H Array	32296183
Intra	PRKAA2	P54646	NRBF2	Homo sapiens	Q96F24	Y2H Prey Pooling	32296183
Intra	PRKAA2	P54646	NRBF2	Homo sapiens	Q96F24	Validated Y2H	32296183
Intra	PRKAA2	P54646	NRBF2	Homo sapiens	Q96F24	Y2H Array	32296183
Intra	PRKAA2	P54646	CCDC172	Homo sapiens	P0C7W6	Y2H Array	32296183
Intra	PRKAA2	P54646	CCDC172	Homo sapiens	P0C7W6	Y2H Prey Pooling	32296183
Intra	PRKAA2	P54646	L3MBTL3	Homo sapiens	Q96JM7	Validated Y2H	25416956
Intra	PRKAA2	P54646	VPS52	Homo sapiens	Q8N1B4	Y2H Prey Pooling	25416956
Intra	PRKAA2	P54646	VPS52	Homo sapiens	Q8N1B4	Y2H Array	25416956
Intra	PRKAA2	P54646	PRKAR1B	Homo sapiens	P31321	Y2H Prey Pooling	32296183
Intra	PRKAA2	P54646	PRKAR1B	Homo sapiens	P31321	Y2H Array	32296183
Intra	PRKAA2	P54646	ARRDC3	Homo sapiens	Q96B67	Y2H Prey Pooling	32296183
Intra	PRKAA2	P54646	ARRDC3	Homo sapiens	Q96B67	Validated Y2H	32296183
Intra	PRKAA2	P54646	ARRDC3	Homo sapiens	Q96B67	Y2H Array	32296183
Intra	PRKAA2	P54646	GLI1	Homo sapiens	P08151	Validated Y2H	25416956
Intra	PRKAA2	P54646	GLI1	Homo sapiens	P08151	Y2H Prey Pooling	25416956
Intra	PRKAA2	P54646	KIAA1328	Homo sapiens	Q86T90	Y2H Prey Pooling	32296183
Intra	PRKAA2	P54646	KIAA1328	Homo sapiens	Q86T90	Validated Y2H	32296183
Intra	PRKAA2	P54646	KIAA1328	Homo sapiens	Q86T90	Y2H Array	32296183
Intra	PRKAA2	P54646	RASAL3	Homo sapiens	Q86YV0	Y2H Prey Pooling	32296183
Intra	PRKAA2	P54646	RASAL3	Homo sapiens	Q86YV0	Validated Y2H	32296183
Intra	PRKAA2	P54646	RASAL3	Homo sapiens	Q86YV0	Y2H Array	32296183
Intra	PRKAA2	P54646	DNM2	Homo sapiens	P50570	Y2H Prey Pooling	32296183
Intra	PRKAA2	P54646	DNM2	Homo sapiens	P50570	Y2H Array	32296183
Intra	PRKAA2	P54646	KRT16	Homo sapiens	P08779	Y2H Array	32296183
Intra	PRKAA2	P54646	KRT16	Homo sapiens	P08779	Y2H Prey Pooling	32296183
Intra	PRKAA2	P54646	YWHAE	Homo sapiens	P62258	Crosslink	36931259
Intra	PRKAA2	P54646	AKAP8L	Homo sapiens	Q9ULX6	Y2H Array	32296183
Intra	PRKAA2	P54646	AKAP8L	Homo sapiens	Q9ULX6	Y2H Prey Pooling	32296183
Intra	PRKAA2	P54646	AKAP8L	Homo sapiens	Q9ULX6	Validated Y2H	32296183
Intra	PRKAA2	P54646	TRIP13	Homo sapiens	Q15645	Validated Y2H	32296183
Intra	PRKAA2	P54646	TRIP13	Homo sapiens	Q15645	Y2H Array	32296183
Intra	PRKAA2	P54646	TRIP13	Homo sapiens	Q15645	Y2H Prey Pooling	32296183
Intra	PRKAA2	P54646	SKIC2	Homo sapiens	Q15477	Validated Y2H	32296183
Intra	PRKAA2	P54646	SKIC2	Homo sapiens	Q15477	Y2H Array	32296183
Intra	PRKAA2	P54646	SKIC2	Homo sapiens	Q15477	Y2H Prey Pooling	32296183
Intra	PRKAA2	P54646	SPRY1	Homo sapiens	O43609	Y2H Array	32296183
Intra	PRKAA2	P54646	SPRY1	Homo sapiens	O43609	Y2H Prey Pooling	32296183
Intra	PRKAA2	P54646	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	PRKAA2	P54646	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	PRKAA2	P54646	RNF11	Homo sapiens	Q9Y3C5	Y2H Array	32814053
Intra	PRKAA2	P54646	RNF11	Homo sapiens	Q9Y3C5	Y2H Pooling	32814053
Intra	PRKAA2	P54646	RNF11	Homo sapiens	Q9Y3C5	Validated Y2H	32814053
Intra	PRKAA2	P54646	KCTD9	Homo sapiens	Q7L273	Validated Y2H	32296183
Intra	PRKAA2	P54646	KCTD9	Homo sapiens	Q7L273	Y2H Prey Pooling	32296183
Intra	PRKAA2	P54646	KCTD9	Homo sapiens	Q7L273	Y2H Array	32296183
Intra	PRKAA2	P54646	VPS37B	Homo sapiens	Q9H9H4	Y2H Prey Pooling	32296183
Intra	PRKAA2	P54646	VPS37B	Homo sapiens	Q9H9H4	Validated Y2H	32296183
Intra	PRKAA2	P54646	VPS37B	Homo sapiens	Q9H9H4	Y2H Array	32296183
Intra	PRKAA2	P54646	TCF4	Homo sapiens	P15884	Y2H Prey Pooling	25416956
Intra	PRKAA2	P54646	ZSCAN23	Homo sapiens	Q3MJ62	Y2H Prey Pooling	32296183
Intra	PRKAA2	P54646	ZSCAN23	Homo sapiens	Q3MJ62	Y2H Array	32296183
Intra	PRKAA2	P54646	ZSCAN23	Homo sapiens	Q3MJ62	Validated Y2H	32296183
Intra	PRKAA2	P54646	GOLGA2	Homo sapiens	Q08379	Y2H Array	32296183
Intra	PRKAA2	P54646	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	32296183
Intra	PRKAA2	P54646	GOLGA2	Homo sapiens	Q08379	Validated Y2H	32296183
Intra	PRKAA2	P54646	TLE5	Homo sapiens	Q08117	Y2H Prey Pooling	25416956
Intra	PRKAA2	P54646	TLE5	Homo sapiens	Q08117	Validated Y2H	25416956
Intra	PRKAA2	P54646	PRKAB1	Homo sapiens	Q9Y478	Y2H Prey Pooling	32296183
Intra	PRKAA2	P54646	PRKAB1	Homo sapiens	Q9Y478	Pull Down	32707033
Intra	PRKAA2	P54646	PRKAB1	Homo sapiens	Q9Y478	Y2H Array	32296183
Intra	PRKAA2	P54646	PRKAB1	Homo sapiens	Q9Y478	Validated Y2H	32296183
Intra	PRKAA2	P54646	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	PRKAA2	P54646	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	PRKAA2	P54646	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	PRKAA2	P54646	TSC22D4	Homo sapiens	Q9Y3Q8	Validated Y2H	25416956
Intra	PRKAA2	P54646	TSC22D4	Homo sapiens	Q9Y3Q8	Y2H Array	25416956
Intra	PRKAA2	P54646	CALCOCO2	Homo sapiens	Q13137	Y2H Prey Pooling	32296183
Intra	PRKAA2	P54646	CALCOCO2	Homo sapiens	Q13137	Validated Y2H	32296183
Intra	PRKAA2	P54646	CALCOCO2	Homo sapiens	Q13137	Y2H Array	32296183
Intra	PRKAA2	P54646	DVL3	Homo sapiens	Q92997	Validated Y2H	32296183
Intra	PRKAA2	P54646	DVL3	Homo sapiens	Q92997	Y2H Prey Pooling	32296183
Intra	PRKAA2	P54646	DVL3	Homo sapiens	Q92997	Y2H Array	32296183
Intra	PRKAA2	P54646	RBPMS	Homo sapiens	Q93062	Y2H Prey Pooling	25416956
Intra	PRKAA2	P54646	GRAP2	Homo sapiens	O75791	Y2H Prey Pooling	32296183
Intra	PRKAA2	P54646	GRAP2	Homo sapiens	O75791	Y2H Array	32296183
Intra	PRKAA2	P54646	TIFA	Homo sapiens	Q96CG3	Y2H Array	32296183
Intra	PRKAA2	P54646	TIFA	Homo sapiens	Q96CG3	Y2H Prey Pooling	32296183
Intra	PRKAA2	P54646	TIFA	Homo sapiens	Q96CG3	Validated Y2H	32296183
Intra	PRKAA2	P54646	LZTS2	Homo sapiens	Q9BRK4	Validated Y2H	32296183
Intra	PRKAA2	P54646	LZTS2	Homo sapiens	Q9BRK4	Y2H Array	32296183
Intra	PRKAA2	P54646	LZTS2	Homo sapiens	Q9BRK4	Y2H Prey Pooling	32296183
Intra	PRKAA2	P54646	TRIP6	Homo sapiens	Q15654	Y2H Array	25416956
Intra	PRKAA2	P54646	ZBTB8A	Homo sapiens	Q96BR9	Y2H Prey Pooling	25416956
Intra	PRKAA2	P54646	ZBTB8A	Homo sapiens	Q96BR9	Validated Y2H	25416956
Intra	PRKAA2	P54646	ZBTB8A	Homo sapiens	Q96BR9	Y2H Array	25416956
Intra	PRKAA2	P54646	ABI2	Homo sapiens	Q9NYB9	Validated Y2H	25416956
Intra	PRKAA2	P54646	ABI2	Homo sapiens	Q9NYB9	Y2H Array	29892012
Intra	PRKAA2	P54646	APPBP2	Homo sapiens	Q92624	Y2H Prey Pooling	25416956
Intra	PRKAA2	P54646	APPBP2	Homo sapiens	Q92624	Validated Y2H	25416956
Intra	PRKAA2	P54646	APPBP2	Homo sapiens	Q92624	Y2H Array	25416956
Intra	PRKAA2	P54646	WWP2	Homo sapiens	O00308	Y2H Prey Pooling	32296183
Intra	PRKAA2	P54646	WWP2	Homo sapiens	O00308	Y2H Array	32296183
Intra	PRKAA2	P54646	CCNB1IP1	Homo sapiens	Q9NPC3	Y2H Array	31515488
Intra	PRKAA2	P54646	CCNB1IP1	Homo sapiens	Q9NPC3	Validated Y2H	25416956
Intra	PRKAA2	P54646	RFX6	Homo sapiens	Q8HWS3	Y2H Array	25416956
Intra	PRKAA2	P54646	RFX6	Homo sapiens	Q8HWS3	Y2H Prey Pooling	25416956
Intra	PRKAA2	P54646	AMOTL2	Homo sapiens	Q9Y2J4	Y2H Array	32296183
Intra	PRKAA2	P54646	AMOTL2	Homo sapiens	Q9Y2J4	Y2H Prey Pooling	32296183
Intra	PRKAA2	P54646	AMOTL2	Homo sapiens	Q9Y2J4	Validated Y2H	32296183
Intra	PRKAA2	P54646	IKZF3	Homo sapiens	Q9UKT9	Y2H Prey Pooling	32296183
Intra	PRKAA2	P54646	IKZF3	Homo sapiens	Q9UKT9	Validated Y2H	32296183
Intra	PRKAA2	P54646	IKZF3	Homo sapiens	Q9UKT9	Y2H Array	32296183
Intra	PRKAA2	P54646	GRN	Homo sapiens	P28799	Validated Y2H	32814053
Intra	PRKAA2	P54646	GRN	Homo sapiens	P28799	Y2H Pooling	32814053
Intra	PRKAA2	P54646	GRN	Homo sapiens	P28799	Y2H Array	32814053
Intra	PRKAA2	P54646	SERTAD3	Homo sapiens	Q9UJW9	Y2H Array	32296183
Intra	PRKAA2	P54646	SERTAD3	Homo sapiens	Q9UJW9	Y2H Prey Pooling	32296183
Intra	PRKAA2	P54646	SERTAD3	Homo sapiens	Q9UJW9	Validated Y2H	32296183
Intra	PRKAA2	P54646	CALCOCO1	Homo sapiens	Q9P1Z2	Y2H Prey Pooling	32296183
Intra	PRKAA2	P54646	CALCOCO1	Homo sapiens	Q9P1Z2	Validated Y2H	32296183
Intra	PRKAA2	P54646	CALCOCO1	Homo sapiens	Q9P1Z2	Y2H Array	32296183
Intra	PRKAA2	P54646	PRPH	Homo sapiens	P41219	Y2H Array	32296183
Intra	PRKAA2	P54646	PRPH	Homo sapiens	P41219	Y2H Prey Pooling	32296183
Intra	PRKAA2	P54646	USH1G	Homo sapiens	Q495M9	Validated Y2H	32296183
Intra	PRKAA2	P54646	USH1G	Homo sapiens	Q495M9	Y2H Array	32296183
Intra	PRKAA2	P54646	USH1G	Homo sapiens	Q495M9	Y2H Prey Pooling	32296183
Cross	PRKAA2	P54646	Stk11	Mus musculus	Q9WTK7	Anti Tag CoIP	19274086
Intra	PRKAA2	P54646	AVPI1	Homo sapiens	Q5T686	Y2H Prey Pooling	32296183
Intra	PRKAA2	P54646	AVPI1	Homo sapiens	Q5T686	Validated Y2H	32296183
Intra	PRKAA2	P54646	AVPI1	Homo sapiens	Q5T686	Y2H Array	32296183
Intra	PRKAA2	P54646	NAB2	Homo sapiens	Q15742	Y2H Array	32296183
Intra	PRKAA2	P54646	NAB2	Homo sapiens	Q15742	Y2H Prey Pooling	32296183
Intra	PRKAA2	P54646	NAB2	Homo sapiens	Q15742	Validated Y2H	32296183
Intra	PRKAA2	P54646	KCTD1	Homo sapiens	Q719H9	Y2H Prey Pooling	25416956
Intra	PRKAA2	P54646	KCTD1	Homo sapiens	Q719H9	Validated Y2H	25416956
Intra	PRKAA2	P54646	ULK1	Homo sapiens	O75385	Anti Tag CoIP	21072212
Intra	PRKAA2	P54646	ULK1	Homo sapiens	O75385	Anti Tag CoIP	20562859
Intra	PRKAA2	P54646	NOTCH2NLA	Homo sapiens	Q7Z3S9	Validated Y2H	25416956
Intra	PRKAA2	P54646	GIGYF1	Homo sapiens	O75420	Y2H Prey Pooling	32296183
Intra	PRKAA2	P54646	GIGYF1	Homo sapiens	O75420	Y2H Array	32296183
Intra	PRKAA2	P54646	KRT31	Homo sapiens	Q15323	Validated Y2H	25416956
Intra	PRKAA2	P54646	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	25416956
Intra	PRKAA2	P54646	STAC2	Homo sapiens	Q6ZMT1	Y2H Prey Pooling	32296183
Intra	PRKAA2	P54646	STAC2	Homo sapiens	Q6ZMT1	Validated Y2H	32296183
Intra	PRKAA2	P54646	STAC2	Homo sapiens	Q6ZMT1	Y2H Array	32296183
Intra	PRKAA2	P54646	MORN3	Homo sapiens	Q6PF18	Y2H Prey Pooling	32296183
Intra	PRKAA2	P54646	MORN3	Homo sapiens	Q6PF18	Validated Y2H	32296183
Intra	PRKAA2	P54646	MORN3	Homo sapiens	Q6PF18	Y2H Array	32296183
Intra	PRKAA2	P54646	MRFAP1	Homo sapiens	Q9Y605	Y2H Array	32296183
Intra	PRKAA2	P54646	MRFAP1	Homo sapiens	Q9Y605	Y2H Prey Pooling	32296183
Intra	PRKAA2	P54646	MRFAP1	Homo sapiens	Q9Y605	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PRKAA2 Proteins

Art. -Nr.	Produktname	Accession	Reinheit
HY-P76142	AMPK gamma 1/beta 1/alpha 2 Heterotrimer Protein, Human (Active, sf9, His-GST)	P54619-1 (M1-P331)&Q9Y478 (M1-I270)&P54646 (M1-R552)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P76144	AMPK gamma 1/beta 2/alpha 2 Heterotrimer Protein, Human (Active, sf9, His-GST)	P54619-1 (M1-P331)&O43741 (M1-I272)&P54646 (M1-R552)	≥ 90%, as determined by reducing SDS-PAGE.

PRKAA2 Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P80377	AMPK alpha 2 Antibody (YA833)	WB, ICC/IF, IHC-P	Human, Mouse, Rat
HY-P80452	Phospho-AMPK alpha 2(Ser345) Antibody (YA225)	WB, ICC/IF, IHC-P	Human, Mouse
HY-P80540	AMPK alpha 2 Antibody (YA623)	WB, IP	Human, Rat
HY-P80540A	AMPK alpha 2 Antibody (YA623)(PBS only)	WB, IP	Human, Rat
HY-P80541	AMPK alpha 2 Antibody (YA622)	WB, IP	Human
HY-P80541A	AMPK alpha 2 Antibody (YA622)(PBS only)	WB, IP	Human
HY-P80791	Phospho-AMPK alpha 2 (Thr172) Antibody	WB	Human, Mouse, Rat
HY-P80791A	Phospho-AMPK alpha 2 (Thr172) Antibody(YA9953)	WB	Human, Mouse, Rat
HY-P810580	Phospho-AMPK alpha 2 (Ser491) Antibody (YA9844)	WB	Human
HY-P84394	AMPK alpha 2 Antibody (YA4091)	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Rat, Monkey, Rabbit
HY-P84394A	AMPK alpha 2 Antibody (YA4091)(PBS only)	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Rat, Monkey, Rabbit

Related Diseases

Diseases	Alias
Peutz-Jeghers Syndrome	PJS Polyposis, Hamartomatous Intestinal Polyps-And-Spots Syndrome Lentiginosis, Perioral Periorificial Lentiginosis Syndrome Hamartomatous Intestinal Polyposis Hamartomatous Polyp Colonic Hamartomatous Polyp Gastric Peutz-Jeghers Polyp Peutz Jeghers Colon Polyp Peutz Jeghers Polyp Peutz-Jeghers Polyp Of Small Intestine Peutz-Jeghers Small Bowel Hamartoma Peutz Jeghers Polyposis Intestinal Polyposis-Cutaneous Pigmentation Syndrome Peutz-Jeghers Polyposis Polyposis, Intestinal, Ii Intestinal Hamartomatous Polyposis Peutz-Jeghers Polyp Peutz-Jeghers Polyp Of The Stomach Peutz Jehgers Polyp Peutz-Jeghers Polyps Of Small Bowel
Ischemia	Acute Coronary Syndrome
Wolff-Parkinson-White Syndrome	Wolff-Parkinson-White Pattern Wpw Syndrome Anomalous Atrioventricular Excitation Anomalous A-V Excitation Ventricular Pre-Excitation With Arrhythmia WPWS Ventricular Familial Preexcitation Syndrome Preexcitation Syndrome Ventricular Preexcitation Wpw - [Wolff-Parkinson- White] Syndrome Pre-Excitation Syndrome
Tuberous Sclerosis	Tuberous Sclerosis Syndrome Bourneville'S Disease Epiloia Cerebral Sclerosis Tuberose Sclerosis Tuberous Sclerosis 1 Bourneville Disease Bourneville Phakomatosis Pringle'S Disease
Hyperglycemia
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Type 2 Diabetes Diabetes Mellitus, Non-Insulin-Dependent T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes
Glycogen Storage Disease	Glycogenosis Glycogenoses Gsd Storage Disease, Glycogen Gsd - [Glycogen Storage Disease] Glycogen Thesaurismosis Diffuse Glycogenosis Generalised Glycogen Storage Disease Generalised Glycogenosis Generalised Glycogen Storage Disease Of Infants Glycogen Synthase Deficiency
Ichthyosis, Congenital, Autosomal Recessive 3	Autosomal Recessive Congenital Ichthyosis 3 ARCI3 Lamellar Ichthyosis 5 Collodion Baby, Self-Healing Ichthyosis, Lamellar, 5, Formerly Li5, Formerly Li5 Self-Healing Collodion Baby Ichthyosis, Congenital, Autosomal Recessive, Type 3
Body Mass Index Quantitative Trait Locus 11	OBESITY Obesity, Susceptibility To Leanness, Inherited Obesity, Susceptibility To, Bmiq11 Obesity, Mild, Early-Onset Obesity, Association With Obesity, Early-Onset, Susceptibility To Obesity, Severe Obesity, Severe, And Type Ii Diabetes Obesity, Late-Onset Obesity , Susceptibility To BMIQ11 Obesity Bmiq11 Obesity, Early-Onset Simple Obesity Nos Excess Fat Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified Adiposis
Hypertrophic Cardiomyopathy	Hypertrophic Obstructive Cardiomyopathy Cardiomyopathy, Hypertrophic Cardiomyopathy Hypertrophic Obstructive Cardiomyopathy, Hypertrophic, Familial Idiopathic Myocardial Hypertrophy Idiopathic Hypertrophic Cardiomyopathy Obstructive Idiopathic Hypertrophic Cardiomyopathy Obstructive Cardiomyopathy Idiopathic Hypertrophic Subaortic Stenosis Muscular Subaortic Stenosis Hypertrophic Obstructive Subaortic Stenosis
Diabetes Mellitus	Diabetes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-P11779	Ac-RKAA-PABC-MMAE	Inhibitor	/	Unkown
HY-P11779A	Ac-RKAA-PABC-MMAE TFA	Inhibitor	/	Unkown
HY-RS21177	Prkaa2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS11101	PRKAA2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27694	Prkaa2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PRKAA2	RGD	RGD:620893
Macaca mulatta	PRKAA2	VGNC	VGNC:76400
Canis familiaris	PRKAA2	VGNC	VGNC:53435
Bos taurus	PRKAA2	VGNC	VGNC:50249
Mus musculus	PRKAA2	MGD	MGI:1336173
Felis catus	PRKAA2	VGNC	VGNC:69046
Others	PRKAA2	NCBI