Stk11 - serine/threonine kinase 11 Gene

Also Known as Lkb1; Par-4

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20869

Summary

This gene encodes a member of the serine/threonine kinase family. The encoded protein, a known tumor suppressor, activates (via phosphorylation) adenine monophosphate-activated protein kinase (AMPK) and AMPK-related kinase proteins. This upstream regulation of the AMPK pathway is thought to regulate a number of different processes, including cell metabolism, cell polarity, Apoptosis and DNA damage response. Mutations in a similar gene in human have been associated with Peutz-Jeghers syndrome. Alternative splicing results in multiple transcript variants, including the S isoform which plays a potential role in spermiogenesis. [provided by RefSeq, Sep 2014]

Stk11 Products (3)

mRNA Protein Name
NM_001301853.2 NP_001288782.1 serine/threonine-protein kinase STK11 isoform S
NM_001301854.2 NP_001288783.1 serine/threonine-protein kinase STK11 isoform 3
NM_011492.5 NP_035622.1 serine/threonine-protein kinase STK11 isoform L

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables LRR domain binding IPI
IPI: Inferred from physical interaction
11741830 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
17482548 MGI
enables protein kinase activator activity IDA
IDA: Inferred from direct assay
17482548 MGI
enables protein kinase activator activity IMP
IMP: Inferred from mutant phenotype
16308421 MGI
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
11853558 MGI
enables protein serine/threonine kinase activity IMP
IMP: Inferred from mutant phenotype
16308421 MGI
Biological Process GO Annotation Evidence Verweise Source
involved in DNA damage response IMP
IMP: Inferred from mutant phenotype
25329316 MGI
acts upstream of or within Golgi localization IMP
IMP: Inferred from mutant phenotype
21111240 MGI
acts upstream of or within T cell receptor signaling pathway IGI
IGI: Inferred from genetic interaction
21487392 MGI
acts upstream of or within T cell receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
21487392 MGI
acts upstream of axonogenesis IGI
IGI: Inferred from genetic interaction
21111240 MGI
involved in axonogenesis IMP
IMP: Inferred from mutant phenotype
17482548 MGI
involved in cellular response to UV-B IDA
IDA: Inferred from direct assay
25329316 MGI
acts upstream of or within dendrite extension IMP
IMP: Inferred from mutant phenotype
24367100 MGI
acts upstream of epithelial cell proliferation involved in prostate gland development IMP
IMP: Inferred from mutant phenotype
18381428 MGI
involved in establishment of cell polarity IMP
IMP: Inferred from mutant phenotype
17482548 MGI
involved in glucose homeostasis IMP
IMP: Inferred from mutant phenotype
16308421 MGI
involved in negative regulation of cell growth IDA
IDA: Inferred from direct assay
11297520 MGI
involved in negative regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
25329316 MGI
involved in negative regulation of cold-induced thermogenesis IMP
IMP: Inferred from mutant phenotype
27461402 MGI
acts upstream of or within negative regulation of epithelial cell proliferation involved in prostate gland development IMP
IMP: Inferred from mutant phenotype
18381428 MGI
acts upstream of or within positive regulation of axonogenesis IGI
IGI: Inferred from genetic interaction
21111240 MGI
acts upstream of or within positive regulation of protein localization to nucleus IMP
IMP: Inferred from mutant phenotype
24768298 MGI
involved in positive regulation of transforming growth factor beta receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
18311138 MGI
involved in positive regulation of vesicle transport along microtubule IMP
IMP: Inferred from mutant phenotype
24643070 MGI
acts upstream of or within positive thymic T cell selection IMP
IMP: Inferred from mutant phenotype
21487392 MGI
involved in protein autophosphorylation IDA
IDA: Inferred from direct assay
11853558 MGI
acts upstream of protein localization to nucleus IMP
IMP: Inferred from mutant phenotype
24768298 MGI
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
25329316 MGI
acts upstream of or within protein phosphorylation IMP
IMP: Inferred from mutant phenotype
24768298 MGI
acts upstream of or within regulation of Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
18381428 MGI
involved in regulation of cell growth IDA
IDA: Inferred from direct assay
11853558 MGI
acts upstream of or within regulation of dendrite morphogenesis IMP
IMP: Inferred from mutant phenotype
24367100 MGI
acts upstream of or within regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: Inferred from mutant phenotype
18381428 MGI
involved in response to ionizing radiation IDA
IDA: Inferred from direct assay
12234250 MGI
involved in spermatid development IMP
IMP: Inferred from mutant phenotype
18774945 MGI
acts upstream of or within tissue homeostasis IMP
IMP: Inferred from mutant phenotype
18381428 MGI
involved in vasculature development IMP
IMP: Inferred from mutant phenotype
11509733 MGI
Cellular Component GO Annotation Evidence Verweise Source
located in cytoplasm IDA
IDA: Inferred from direct assay
10400995 MGI
located in cytosol IDA
IDA: Inferred from direct assay
11297520 MGI
located in membrane IDA
IDA: Inferred from direct assay
11297520 MGI
located in nucleus IDA
IDA: Inferred from direct assay
10400995 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

serine/threonine-protein kinase STK11

  • liver kinase B1 homolog

  • serine/threonine-protein kinase 11

  • serine/threonine-protein kinase LKB1

Stk11 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Cross
Stk11 Q9WTK7 PRKAA2 Homo sapiens P54646
Anti Tag CoIP
19274086
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname Wirkung
Reinheit Phase
HY-153358 TNG260 Inhibitor 99.33% Phase 2

Pre-clinical Phase

Bioactive Molecules (7)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-P5435 LKBtide Substrate 95.59% Unkown
HY-153358A (S)-TNG260 98.39% Unkown
HY-RS13921 STK11 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-N6904 Crocetin monomethyl ester Inhibitor 98.44% Unkown
HY-RS13922 STK11IP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17308 Stk11 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23763 Stk11 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Stk11 NCBI NCBI:6794