STK11 - serine/threonine kinase 11 Gene

Also Known as PJS; LKB1; hLKB1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6794

About STK11

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:1,205,778-1,228,431 (from NCBI)

This gene has 9 transcripts (splice variants), 220 orthologues, 22 paralogues and is associated with 119 phenotypes. Broad expression in testis (RPKM 28.3), spleen (RPKM 10.4) and 25 other tissues.

Summary

The protein encoded by this gene is a serine/threonine kinase that regulates cell polarity and energy metabolism and functions as a tumor suppressor. Mutations in this gene have been associated with the autosomal dominant Peutz-Jeghers syndrome, as well as with skin, pancreatic, and testicular cancers. [provided by RefSeq, May 2022]

STK11 Products (2)

mRNA	Protein	Name
NM_000455.5	NP_000446.1	serine/threonine-protein kinase STK11 isoform 1
NM_001407255.1	NP_001394184.1	serine/threonine-protein kinase STK11 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ATP binding	IDA IDA: Inferred from direct assay	12805220	GOA
enables magnesium ion binding	IDA IDA: Inferred from direct assay	12805220	GOA
enables p53 binding	IDA IDA: Inferred from direct assay	11430832	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12595760	GOA
enables protein kinase activator activity	IDA IDA: Inferred from direct assay	19892943	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	11430832	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in DNA damage response	IMP IMP: Inferred from mutant phenotype	25329316	GOA
acts upstream of negative effect G1 to G0 transition	IDA IDA: Inferred from direct assay	17216128	GOA
acts upstream of negative effect G1 to G0 transition	IPI IPI: Inferred from physical interaction	12805220	GOA
acts upstream of or within activation of protein kinase activity	IDA IDA: Inferred from direct assay	18854309	GOA
involved in activation of protein kinase activity	IMP IMP: Inferred from mutant phenotype	15731909	GOA
involved in anoikis	IMP IMP: Inferred from mutant phenotype	19622832	GOA
involved in cellular response to UV-B	IDA IDA: Inferred from direct assay	25329316	GOA
involved in establishment of cell polarity	IMP IMP: Inferred from mutant phenotype	24643070	GOA
involved in intrinsic apoptotic signaling pathway by p53 class mediator	IDA IDA: Inferred from direct assay	11430832	GOA
involved in negative regulation of TORC1 signaling	IMP IMP: Inferred from mutant phenotype	23878245	GOA
involved in negative regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	15731909	GOA
involved in negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	17216128	GOA
involved in peptidyl-threonine phosphorylation	IDA IDA: Inferred from direct assay	12805220	GOA
involved in positive regulation of autophagy	IMP IMP: Inferred from mutant phenotype	23878245	GOA
involved in positive regulation of transforming growth factor beta receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	18311138	GOA
involved in positive regulation of vesicle transport along microtubule	IMP IMP: Inferred from mutant phenotype	24643070	GOA
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	11430832	GOA
involved in protein dephosphorylation	IMP IMP: Inferred from mutant phenotype	15731909	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	12805220	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	11430832	GOA
part of intracellular protein-containing complex	IDA IDA: Inferred from direct assay	12805220	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	11430832	GOA
located in nucleus	IDA IDA: Inferred from direct assay	12805220	GOA
part of serine/threonine protein kinase complex	IPI IPI: Inferred from physical interaction	19892943	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STK11 Protein Structure

Pkinase

0
100
200
300
400
433 a.a.

Protein Preferred Names	Protein Names
serine/threonine-protein kinase STK11	liver kinase B1

STK11 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	STK11	Q15831	STRADA	Homo sapiens	Q7RTN6	Protein Kinase Assay	12805220
Intra	STK11	Q15831	STRADA	Homo sapiens	Q7RTN6	PLA	25241761
Intra	STK11	Q15831	STRADA	Homo sapiens	Q7RTN6	Anti Tag CoIP	14676191
Intra	STK11	Q15831	STRADA	Homo sapiens	Q7RTN6	Anti Tag CoIP	20562859
Intra	STK11	Q15831	STRADA	Homo sapiens	Q7RTN6	Anti Tag CoIP	34591612
Intra	STK11	Q15831	STRADA	Homo sapiens	Q7RTN6	Affinity Chrom	15733851
Intra	STK11	Q15831	STRADA	Homo sapiens	Q7RTN6	Anti Tag CoIP	25852190
Intra	STK11	Q15831	STRADA	Homo sapiens	Q7RTN6	Anti Tag CoIP	33961781
Intra	STK11	Q15831	STRADA	Homo sapiens	Q7RTN6	Anti Tag CoIP	28514442
Intra	STK11	Q15831	STRADA	Homo sapiens	Q7RTN6	Pull Down	32707033
Intra	STK11	Q15831	STRADA	Homo sapiens	Q7RTN6	Anti Tag CoIP	35271311
Intra	STK11	Q15831	PRKAA2	Homo sapiens	P54646	PLA	25241761
Intra	STK11	Q15831	PRKAA2	Homo sapiens	P54646	Anti Bait CoIP	19274086
Intra	STK11	Q15831	WDR6	Homo sapiens	Q9NNW5	IF	17216128
Intra	STK11	Q15831	WDR6	Homo sapiens	Q9NNW5	Anti Tag CoIP	17216128
Intra	STK11	Q15831	STRADA	Homo sapiens	Q7RTN6-1	Anti Bait CoIP	26479318
Intra	STK11	Q15831	CDC37	Homo sapiens	Q16543	Pull Down	32707033
Intra	STK11	Q15831	CDC37	Homo sapiens	Q16543	Anti Tag CoIP	34591612
Intra	STK11	Q15831	CDC37	Homo sapiens	Q16543	Lumier	25036637
Intra	STK11	Q15831	CDC37	Homo sapiens	Q16543	Anti Tag CoIP	20562859
Intra	STK11	Q15831	CDC37	Homo sapiens	Q16543	Anti Tag CoIP	14676191
Intra	STK11	Q15831	HSP90AA1	Homo sapiens	P07900	Lumier	25036637
Intra	STK11	Q15831	HSP90AA1	Homo sapiens	P07900	Anti Tag CoIP	33961781
Intra	STK11	Q15831	HSP90AA1	Homo sapiens	P07900	Pull Down	32707033
Intra	STK11	Q15831	HSP90AA1	Homo sapiens	P07900	Anti Tag CoIP	14676191
Intra	STK11	Q15831	MARK4	Homo sapiens	Q96L34	Protein Kinase Assay	14676191
Intra	STK11	Q15831	STRADB	Homo sapiens	Q9C0K7	Pull Down	32707033
Intra	STK11	Q15831	STRADB	Homo sapiens	Q9C0K7	Anti Tag CoIP	14676191
Intra	STK11	Q15831	STRADB	Homo sapiens	Q9C0K7	Anti Tag CoIP	34591612
Intra	STK11	Q15831	STRADB	Homo sapiens	Q9C0K7	Anti Tag CoIP	35271311
Intra	STK11	Q15831	STRADB	Homo sapiens	Q9C0K7	Anti Tag CoIP	20562859
Intra	STK11	Q15831	STRADB	Homo sapiens	Q9C0K7	Anti Tag CoIP	33961781
Intra	STK11	Q15831	CAB39	Homo sapiens	Q9Y376	Pull Down	19513107
Intra	STK11	Q15831	CAB39	Homo sapiens	Q9Y376	Anti Tag CoIP	25852190
Intra	STK11	Q15831	CAB39	Homo sapiens	Q9Y376	Anti Tag CoIP	33961781
Intra	STK11	Q15831	CAB39	Homo sapiens	Q9Y376	Anti Bait CoIP	26479318
Intra	STK11	Q15831	CAB39	Homo sapiens	Q9Y376	Anti Tag CoIP	35271311
Intra	STK11	Q15831	CAB39	Homo sapiens	Q9Y376	Anti Tag CoIP	34591612
Intra	STK11	Q15831	CAB39	Homo sapiens	Q9Y376	Anti Tag CoIP	14676191
Intra	STK11	Q15831	CAB39	Homo sapiens	Q9Y376	Anti Tag CoIP	20562859
Intra	STK11	Q15831	CAB39	Homo sapiens	Q9Y376	Pull Down	32707033
Intra	STK11	Q15831	CAB39	Homo sapiens	Q9Y376	Affinity Chrom	15733851
Intra	STK11	Q15831	CAB39	Homo sapiens	Q9Y376	Anti Tag CoIP	28514442
Intra	STK11	Q15831	FKBP5	Homo sapiens	Q13451	Anti Tag CoIP	20562859
Intra	STK11	Q15831	FKBP5	Homo sapiens	Q13451	Anti Tag CoIP	25852190
Intra	STK11	Q15831	FKBP5	Homo sapiens	Q13451	Anti Tag CoIP	33961781
Intra	STK11	Q15831	FKBP5	Homo sapiens	Q13451	Anti Tag CoIP	28514442
Intra	STK11	Q15831	FKBP5	Homo sapiens	Q13451	Anti Tag CoIP	14676191
Intra	STK11	Q15831	FKBP5	Homo sapiens	Q13451	Pull Down	32707033
Intra	STK11	Q15831	FKBP5	Homo sapiens	Q13451	Anti Tag CoIP	34591612
Intra	STK11	Q15831	YWHAZ	Homo sapiens	P63104	Pull Down	22575644
Intra	STK11	Q15831	YWHAZ	Homo sapiens	P63104	IF	22575644
Intra	STK11	Q15831	HSP90AB1	Homo sapiens	P08238	Anti Tag CoIP	33961781
Intra	STK11	Q15831	HSP90AB1	Homo sapiens	P08238	Pull Down	32707033
Intra	STK11	Q15831	HSP90AB1	Homo sapiens	P08238	Anti Tag CoIP	28514442
Intra	STK11	Q15831	HSP90AB1	Homo sapiens	P08238	Anti Tag CoIP	22939624
Intra	STK11	Q15831	TNIP2	Homo sapiens	Q8NFZ5	Pull Down	12595760
Intra	STK11	Q15831	TNIP2	Homo sapiens	Q8NFZ5	Y2H	12595760
Intra	STK11	Q15831	TNIP2	Homo sapiens	Q8NFZ5	Anti Bait CoIP	12595760
Intra	STK11	Q15831	LATS1	Homo sapiens	O95835	Anti Tag CoIP	24362629
Intra	STK11	Q15831	LATS1	Homo sapiens	O95835	Anti Bait CoIP	24362629
Intra	STK11	Q15831	MST1	Homo sapiens	P26927	Anti Bait CoIP	24362629
Intra	STK11	Q15831	MST1	Homo sapiens	P26927	Anti Tag CoIP	24362629
Intra	STK11	Q15831	COPS4	Homo sapiens	Q9BT78	Pull Down	32707033
Intra	STK11	Q15831	COPS4	Homo sapiens	Q9BT78	Anti Tag CoIP	25852190
Intra	STK11	Q15831	COPS4	Homo sapiens	Q9BT78	Anti Tag CoIP	34591612

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant STK11 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71549	STK11 Protein, Human (His-SUMO)	Q15831 (M1-C430)	≥ 90%, as determined by reducing SDS-PAGE.

STK11 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P84605	STK11 Antibody (YA4302)	WB, FC, ELISA	Human, Mouse, Monkey
HY-P84605A	STK11 Antibody (YA4302)(PBS only)	WB, FC, ELISA	Human, Mouse, Monkey
HY-P85260	LKB1 Antibody (YA4952)	WB, IHC-P	Human, Mouse, Rat
HY-P86340	LKB1 Antibody (YA6032)	WB, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Peutz-Jeghers Syndrome	PJS Polyposis, Hamartomatous Intestinal Polyps-And-Spots Syndrome Lentiginosis, Perioral Periorificial Lentiginosis Syndrome Hamartomatous Intestinal Polyposis Hamartomatous Polyp Colonic Hamartomatous Polyp Gastric Peutz-Jeghers Polyp Peutz Jeghers Colon Polyp Peutz Jeghers Polyp Peutz-Jeghers Polyp Of Small Intestine Peutz-Jeghers Small Bowel Hamartoma Peutz Jeghers Polyposis Intestinal Polyposis-Cutaneous Pigmentation Syndrome Peutz-Jeghers Polyposis Polyposis, Intestinal, Ii Intestinal Hamartomatous Polyposis Peutz-Jeghers Polyp Peutz-Jeghers Polyp Of The Stomach Peutz Jehgers Polyp Peutz-Jeghers Polyps Of Small Bowel
Testicular Germ Cell Tumor	Male Germ Cell Tumor Testicular Teratoma TGCT Mgct Male Germ Cell Tumor, Somatic Spermatocytic Seminoma, Somatic Embryonal Cell Carcinoma Seminoma Spermatocytic Seminoma Germ Cell Tumors, Somatic Testicular Tumor, Somatic Non-Seminomatous Germ Cell Tumor Of Testis Non-Dysgerminomatous Germ Cell Tumor Of Testis Testicular Non Seminomatous Germ Cell Tumor Testicular Non-Dysgerminomatous Germ Cell Tumor Teratoma Of The Testis Endodermal Sinus Tumor Nonseminomatous Germ Cell Tumors Teratoma Testicular Germ Cell Tumor, Somatic Embryonal Carcinoma Cell Yolk Sac Tumor Malignant Testicular Non-Seminomatous Germ Cell Tumor Testicular Non-Seminomatous Germ Cell Tumor Teratoma Of Testis Nonseminomatous Germ Cell Tumor
Pancreatic Cancer	Pancreatic Carcinoma Carcinoma Of Pancreas Familial Pancreatic Carcinoma Pancreatic Neoplasm Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Cancer Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Melanoma, Cutaneous Malignant 1	Familial Melanoma Melanoma, Cutaneous Malignant, Susceptibility To, 1 Melanoma, Malignant CMM1 Melanoma, Cutaneous Malignant Cmm Familial Atypical Mole-Malignant Melanoma Syndrome Fammm Melanoma, Familial Mlm Dysplastic Nevus Syndrome, Hereditary Dns B-K Mole Syndrome Melanoma, Cutaneous Malignant, 1 Malignant Melanoma, Cutaneous Melanoma, Cutaneous, Malignant, Susceptibility To, Type 1 Dysplastic Nevus Syndrome Cutaneous Melanoma Familial Atypical Mole Melanoma Syndrome Hereditary Melanoma
Testicular Cancer	Testis Cancer Testicular Carcinoma Testicular Neoplasms Malignant Neoplasm Of Testis Childhood Neoplasm Of The Testis Neoplasm Of Testis Pediatric Testicular Neoplasm Testicular Tumor Testis Neoplasm Testicular Tumors Testicular Neoplasm Testicular Malignant Germ Cell Tumor Childhood Testicular Neoplasm Carcinoma Of The Testis Cancer Of Testis Malignant Neoplasm Of Testis, Nos Malignant Neoplasm Of Testis, Unspecified Malignant Tumour Of Testis Testicle Cancer Primary Malignant Neoplasm Of Testis
Testicular Germ Cell Cancer	Germ Cell Tumor Of Testis Testicular Germ Cell Tumor Testicular Germ Cell Neoplasm Testicular Malignant Germ Cell Tumor
Generalized Juvenile Polyposis/Juvenile Polyposis Coli
Lip And Oral Cavity Cancer	Oral Cancer Lip And Oral Cavity Carcinoma Malignant Neoplasm Of Mouth
Inherited Cancer-Predisposing Syndrome	Hereditary Cancer-Predisposing Syndrome
Bap1 Tumor Predisposition Syndrome	Bap1-Related Tumor Predisposition Syndrome Common Syndrome Bap1 Cancer Syndrome Bap1-Tpds Cutaneous/Ocular Melanoma, Atypical Melanocytic Proliferations, And Other Internal Neoplasms Tumor Predisposition Syndrome Tumor Susceptibility Linked To Germline Bap1 Mutations Cutaneous/Ocular Melanoma, Atypical Melanocytic Proliferations, Other Internal Neoplasms Tumor Predisposition
Intestinal Polyposis Syndrome	Intestinal Polyposis
Intussusception	Intussusception Of Intestine Invagination Of Intestine Or Colon
Familial Adenomatous Polyposis 1	Gardner Syndrome Brain Tumor-Polyposis Syndrome 2 Familial Polyposis Of The Colon Adenomatous Polyposis Coli FAP1 Adenomatous Polyposis Of The Colon Apc Fpc Gardner'S Syndrome Polyposis, Adenomatous Intestinal Adenoma, Periampullary, Somatic Intestinal Polyposis, Osteomas, Sebaceous Cysts Polyposis Coli And Multiple Hard And Soft Tissue Tumors Apc-Related Attenuated Familial Adenomatous Polyposis Apc-Related Afap Apc-Related Attenuated Fap Apc-Related Attenuated Familial Polyposis Coli Turcot Syndrome With Polyposis Gardners Syndrome Adenomatous Polyposis Coli, Susceptibility To Adenomatous Polyposis, Familial, Type 1
Apc-Associated Polyposis Conditions
Juvenile Polyposis Syndrome	JPS Juvenile Intestinal Polyposis Jip Pji Juvenile Gastrointestinal Polyposis Juvenile Polyposis Polyposis, Juvenile Intestinal Polyposis, Familial, Of Entire Gastrointestinal Tract Polyposis Familial Of Entire Gastrointestinal Tract Polyposis Juvenile Intestinal Polyposis Syndrome, Juvenile
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Lung Squamous Cell Carcinoma	Squamous Cell Carcinoma Of Lung Squamous Cell Lung Carcinoma Epidermoid Cell Carcinoma Of The Lung Squamous Cell Lung Cancer
Polyhydramnios, Megalencephaly, And Symptomatic Epilepsy	Pmse Syndrome PMSE Polyhydramnios, Megalencephaly, And Symptomatic Epilepsy Syndrome Pretzel Syndrome Polyhydramnios-Megalencephaly-Symptomatic Epilepsy Syndrome
Tuberous Sclerosis	Tuberous Sclerosis Syndrome Bourneville'S Disease Epiloia Cerebral Sclerosis Tuberose Sclerosis Tuberous Sclerosis 1 Bourneville Disease Bourneville Phakomatosis Pringle'S Disease
Squamous Cell Carcinoma	Epidermoid Carcinoma Squamous Cell Cancer Carcinoma, Squamous Cell Squamous Cell Skin Cancer Malignant Squamous Cell Tumor Squamous Carcinoma Squamous Cell Epithelioma Carcinoma Squamous Cell Neoplasms, Squamous Cell Squamous Cell Carcinoma - Category Malignant Squamous Cell Neoplasm Squamous Cell Carcinoma Of Skin
Lung Cancer Susceptibility 3	Lung Adenocarcinoma Adenocarcinoma Of Lung LNCR3 Adenocarcinoma Of Lung, Susceptibility To Bronchogenic Lung Adenocarcinoma Nonsmall Cell Adenocarcinoma Adenocarcinoma Lung Lung Adenocarcinomas Non-Small Cell Adenocarcinoma
Cervical Adenoma Malignum	Cervical Mucinous Adenocarcinoma, Minimal Deviation Variant
Lentigines	Lentigo
Pancreatic Intraductal Papillary-Colloid Carcinoma	Intraductal Papillary-Mucinous Carcinoma Of Pancreas Intraductal Papillary Mucinous Carcinoma Of Pancreas Ipmn Pancreatic Intraductal Papillary Mucinous Carcinoma Pancreatic Intraductal Papillary-Mucinous Carcinoma
Adenocarcinoma	Adenocarcinomas Adenoacanthoma Of Unspecified Site Adenocarcinoid Of Unspecified Site Adenocarcinoid Tumour Of Unspecified Site Adenocarcinoma And Carcinoid Combined Of Unspecified Site Adenocarcinoma Nos
Cowden Syndrome 1	Bannayan-Riley-Ruvalcaba Syndrome Pten Hamartoma Tumor Syndrome Lhermitte-Duclos Disease Bannayan-Zonana Syndrome Phts Riley-Smith Syndrome Bzs Ruvalcaba-Myhre-Smith Syndrome Multiple Hamartoma Syndrome Rmss Brrs Dysplastic Gangliocytoma Of The Cerebellum CWS1 Cs Cd Mham Pten Hamartoma Tumor Syndrome With Granular Cell Tumor Macrocephaly Multiple Lipomas And Hemangiomata Bannayan-Ruvalcaba-Riley Syndrome Myhre-Riley-Smith Syndrome LDD Cerebelloparenchymal Disorder Vi Hamartoma Syndrome, Multiple Bbrs Macrocephaly, Pseudopapilledema, And Multiple Hemangiomata Macrocephaly, Multiple Lipomas, And Hemangiomata Macrocephaly Pseudopapilledema And Multiple Hemangiomas Ruvalcaba -Myhre-Smith Syndrome Ruvalcaba-Myhre Syndrome Cowden Disease Macrocephaly Pseudopapilledema And Multiple Hemangiomata Cerebellar Granule Cell Hypertrophy And Megalencephaly Cpd6 Pten Hamartoma Tumor Syndromes Cowden Syndrome, Type 1
Cowden Syndrome	Cowden Disease Multiple Hamartoma Syndrome Cowden'S Disease Lhermitte-Duclos Disease Cd Cs Mham Dysplastic Gangliocytoma Of Cerebellum Cowden'S Syndrome Hamartoma Syndrome, Multiple
Cervical Mucinous Adenocarcinoma
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas
Pulmonary Large Cell Neuroendocrine Carcinoma	Large Cell Lung Neuroendocrine Carcinoma
Polyhydramnios
Diffuse Gastric And Lobular Breast Cancer Syndrome	Hereditary Diffuse Gastric Cancer HDGC LBC Familial Diffuse Gastric Cancer Fdgc Hereditary Diffuse Gastric Adenocarcinoma Breast Cancer, Lobular Gastric Cancer, Familial Diffuse, And Cleft Lip With Or Without Cleft Palate DGLBC Gastric Cancer, Hereditary Diffuse Gastric Cancer, Familial Diffuse Breast Cancer, Lobular Diffuse Gastric And Lobular Breast Cancer Syndrome With Or Without Cleft Lip And/Or Palate E-Cadherin-Associated Hereditary Gastric Cancer Familial Diffuse Cancer Of Stomach Hereditary Diffuse Cancer Of Stomach Gastric Cancer Familial Diffuse Gastric Cancer Familial Diffuse And Cleft Lip With Or Without Cleft Palate Cancer, Gastric, Hereditary Diffuse
Dysplastic Nevus Syndrome	Familial Atypical Multiple Mole-Melanoma Familial Atypical Multiple Mole Melanoma Syndrome Melanoma-Pancreatic Cancer Syndrome Famm Syndrome B-K Mole Syndrome Famm-Pc Syndrome Fammm Syndrome Familial Atypical Mole Syndrome Familial Atypical Multiple Mole Melanoma-Pancreatic Carcinoma Syndrome Familial Dysplastic Nevus Syndrome Familial Atypical Multiple Mole Melanoma Dysplastic Nevus Familial Atypical Mole Melanoma Syndrome
Germ Cell Tumor
Small Intestine Cancer	Small Intestine Carcinoma Cancer Of The Small Bowel Small Bowel Cancer Small Intestinal Carcinoma Malignant Neoplasms Of The Small Intestine Small Bowel Tumors Malignant Tumor Of Small Intestine Neoplasm Of Small Intestine
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Ataxia-Telangiectasia	Ataxia Telangiectasia Louis-Bar Syndrome AT At1 Ataxia-Telangiectasia Syndrome Ataxia - Telangiectasia Variant Boder-Sedgwick Syndrome Louis Bar Syndrome Cerebello-Oculocutaneous Telangiectasia Immunodeficiency With Ataxia Telangiectasia A-T Ataxia Telangiectasia Syndrome Atm Telangiectasia, Cerebello-Oculocutaneous Ataxia-Telangiectasia Variant
Hereditary Mixed Polyposis Syndrome	Hmps
Diffuse Gastric Cancer	Hereditary Diffuse Gastric Adenocarcinoma Hereditary Diffuse Gastric Cancer Signet Cell Adenocarcinoma Signet Ring Cell Carcinoma Signet Ring Cell Gastric Carcinoma Signet Ring Gastric Carcinoma Fdgc Familial Diffuse Cancer Of Stomach Familial Diffuse Gastric Cancer Gastric Cancer, Familial Diffuse Gastric Cancer, Hereditary Diffuse Hdgc Hereditary Diffuse Cancer Of Stomach Diffuse Gastric Cancer Syndrome Cancer, Gastric, Diffuse Carcinoma, Signet Ring Cell Gastric Signet Ring Carcinoma
Lung Benign Neoplasm	Lung Neoplasms Tumor Of The Lung Lung Tumor
Pancreatic Serous Cystadenoma
Vaginal Tubulovillous Adenoma
Cervical Cancer	Cervical Cancer, Somatic Neoplasm Of Uterine Cervix Cervix Cancer Uterine Cervical Neoplasm Cervical Neoplasm Cervix Uteri Cancer Tumor Of The Cervix Uteri CERCA Uterine Cervical Cancer Neoplasms Cervical Uterine Cervical Neoplasms Cervical Cancers Cancer, Cervical, Somatic Malignant Tumor Of Cervix Cervix Carcinoma
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Lung Non-Squamous Non-Small Cell Carcinoma	Non- Squamous Nsclc
Familial Adenomatous Polyposis 2	Mutyh-Related Attenuated Familial Adenomatous Polyposis FAP2 Colorectal Adenomatous Polyposis, Autosomal Recessive Adenomas, Multiple Colorectal Mutyh-Associated Polyposis Mutyh-Related Attenuated Familial Polyposis Coli Mutyh-Related Attenuated Fap Adenomas, Multiple Colorectal, Autosomal Recessive Mutyh-Related Afap Adenomas Multiple Colorectal Autosomal Recessive Colorectal Adenomatous Polyposis Autosomal Recessive Adenomatous Polyposis, Familial, Type 2
Li-Fraumeni Syndrome	Sarcoma Family Syndrome Of Li And Fraumeni Sbla Syndrome LFS Li-Fraumeni Familiar Cancer Susceptibility Syndrome Sarcoma, Breast, Leukaemia And Adrenal Gland Syndrome Lfs1 Li Fraumeni Syndrome Sarcoma, Breast, Leukemia, And Adrenal Gland Syndrome Lfl Sbla Syndrome Li-Fraumeni-Like Syndrome Li-Fraumeni Syndrome 1
Dowling-Degos Disease 1	Reticular Pigment Anomaly Of Flexures DDD1 Ddd Hyperpigmentation Dowling-Degos Disease
Lynch Syndrome	Hereditary Nonpolyposis Colon Cancer Hereditary Nonpolyposis Colorectal Cancer Hereditary Nonpolyposis Colorectal Carcinoma Hereditary Nonpolyposis Colorectal Neoplasms Familial Nonpolyposis Colon Cancer Hnpcc Coca 1 Hereditary Defective Mismatch Repair Syndrome Hereditary Non-Polyposis Colon Cancer Hereditary Non-Polyposis Colon Cancer Syndrome Hereditary Non-Polyposis Colorectal Cancer Hereditary Non-Polyposis Colorectal Cancer Syndrome Hereditary Nonpolyposis Colon Cancer Syndrome Hereditary Nonpolyposis Colorectal Cancer Syndrome Hereditary Nonpolyposis Colorectal Neoplasm Hnpcc - Hereditary Nonpolyposis Colon Cancer Cancer Family Syndrome Familial Nonpolyposis Colorectal Cancer Colon Cancer, Familial Nonpolyposis Colorectal Neoplasms, Hereditary Nonpolyposis Cancer, Colorectal, Nonpolyposis, Hereditary Colorectal Cancer, Hereditary Nonpolyposis, Type 1
Bilateral Breast Cancer	Bilateral Breast Carcinoma
Vaginal Adenoma
Lung Large Cell Carcinoma	Large Cell Carcinoma Of Lung Large Cell Lung Carcinoma Large Cell Lung Cancer
Neurodegeneration With Brain Iron Accumulation	Nbia Neurodegeneration With Brain Iron Accumulation Disorders Neurodegeneration, With Brain Iron Accumulation
Hereditary Breast Ovarian Cancer Syndrome	Hereditary Breast And Ovarian Cancer Syndrome Brca1- And Brca2-Associated Hereditary Breast And Ovarian Cancer Breast And/Or Ovarian Cancer Breast And Ovarian Cancer Syndrome Hboc Syndrome Hereditary Breast And Ovarian Cancer Brca1- Brca2-Associated Hboc
Gastric Cancer	Stomach Cancer Gastric Carcinoma Stomach Carcinoma Gastric Cancer, Somatic Gastric Neoplasm Carcinoma Of Stomach Stomach Neoplasms Malignant Neoplasm Of Stomach Gastric Cancer Risk After H. Pylori Infection Cancer Of The Stomach Adult Stomach Cancer Adult Stomach Carcinoma GASC Gastric Cancer Intestinal Gastric Cancers Gastric Carcinomas Cancer, Gastric Stomach Neoplasm Malignant Neoplasm Of Body Of Stomach Malignant Tumor Of Lesser Curve Of Stomach Gastrocarcinoma Of Unspecified Site Leather Bottle Stomach Carcinoma Of Fundus Of Stomach Cancer Of Fundus Of Stomach Primary Malignant Neoplasm Of Body Of Stomach Cancer Of Body Of Stomach Primary Malignant Neoplasm Of Pyloric Antrum Pyloric Antrum Cancer Malignant Tumour Of Stomach
Long Qt Syndrome	Romano-Ward Syndrome Long Q-T Syndrome Lqt Qt Syndrome, Long Congenital Long Qt Syndrome Familial Long Qt Syndrome
Vaginal Benign Neoplasm
Diamond-Blackfan Anemia 20	DBA20 Rps15a-Related Diamond-Blackfan Anemia
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Papillary Adenofibroma
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Type 2 Diabetes Diabetes Mellitus, Non-Insulin-Dependent T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-153358	TNG260	Inhibitor	99.33%	Phase 2

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P5435	LKBtide	Substrate	95.59%	Unkown
HY-153358A	(S)-TNG260		98.39%	Unkown
HY-RS13921	STK11 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-N6904	Crocetin monomethyl ester	Inhibitor	98.44%	Unkown
HY-RS13922	STK11IP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17308	Stk11 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23763	Stk11 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	STK11	VGNC	VGNC:65774
Bos taurus	STK11	VGNC	VGNC:35385
Canis familiaris	STK11	VGNC	VGNC:54369
Rattus norvegicus	STK11	RGD	RGD:1308653
Mus musculus	STK11	MGD	MGI:1341870
Macaca mulatta	STK11	VGNC	VGNC:82249
Others	STK11	NCBI