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MARK4 - microtubule affinity regulating kinase 4 Gene

Also Known as MARK4L; MARK4S; MARKL1; PAR-1D; MARKL1L

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 57787

About MARK4

Cytogenetic location: 19q13.32 Genomic coordinates (GRCh38): 19:45,251,271-45,305,284 (from NCBI)

This gene has 9 transcripts (splice variants), 270 orthologues and 3 paralogues. Broad expression in testis (RPKM 14.0), brain (RPKM 8.1) and 25 other tissues.

Summary

This gene encodes a member of the microtubule affinity-regulating kinase family. These protein kinases phosphorylate microtubule-associated proteins and regulate the transition between stable and dynamic microtubules. The encoded protein is associated with the centrosome throughout Mitosis and may be involved in cell cycle control. Expression of this gene is a potential marker for Cancer, and the encoded protein may also play a role in Alzheimer's disease. Pseudogenes of this gene are located on both the short and long arm of chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]

MARK4 Products (2)

mRNA	Protein	Name
NM_001199867.2	NP_001186796.1	MAP/microtubule affinity-regulating kinase 4 isoform 1
NM_031417.4	NP_113605.2	MAP/microtubule affinity-regulating kinase 4 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables cytoskeletal anchor activity	IDA IDA: Inferred from direct assay	28656979	GOA
enables gamma-tubulin binding	IDA IDA: Inferred from direct assay	14594945	GOA
enables microtubule binding	IDA IDA: Inferred from direct assay	14594945	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	14594945	GOA
enables tau-protein kinase activity	IDA IDA: Inferred from direct assay	14594945	GOA
enables tau-protein kinase activity	IMP IMP: Inferred from mutant phenotype	23666762	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cilium organization	IGI IGI: Inferred from genetic interaction	23400999	GOA
involved in microtubule bundle formation	IEP IEP: Inferred from expression pattern	14594945	GOA
NOT involved in microtubule cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	23400999	GOA
involved in microtubule cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	14594945	GOA
involved in nervous system development	IDA IDA: Inferred from direct assay	14594945	GOA
involved in positive regulation of NLRP3 inflammasome complex assembly	IDA IDA: Inferred from direct assay	28656979	GOA
acts upstream of or within positive regulation of cell cycle	IDA IDA: Inferred from direct assay	26882547	GOA
involved in positive regulation of cilium assembly	IMP IMP: Inferred from mutant phenotype	23400999	GOA
involved in positive regulation of protein localization to centrosome	IMP IMP: Inferred from mutant phenotype	23400999	GOA
involved in protein phosphorylation	IMP IMP: Inferred from mutant phenotype	23666762	GOA
involved in regulation of centrosome cycle	IMP IMP: Inferred from mutant phenotype	25123532	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in centrosome	IDA IDA: Inferred from direct assay	14594945	GOA
located in ciliary basal body	IMP IMP: Inferred from mutant phenotype	23400999	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	23666762	GOA
located in dendrite	IDA IDA: Inferred from direct assay	23666762	GOA
part of gamma-tubulin complex	IDA IDA: Inferred from direct assay	25123532	GOA
located in microtubule cytoskeleton	IDA IDA: Inferred from direct assay	14594945	GOA
is active in microtubule organizing center	IDA IDA: Inferred from direct assay	28656979	GOA
located in microtubule organizing center	IDA IDA: Inferred from direct assay	14594945	GOA
located in midbody	IDA IDA: Inferred from direct assay	25123532	GOA
located in neuron projection	IDA IDA: Inferred from direct assay	14594945	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MARK4 Protein Structure

Pkinase

UBA

KA1

0
200
400
600
752 a.a.

Protein Preferred Names	Protein Names
MAP/microtubule affinity-regulating kinase 4	MAP/microtubule affinity-regulating kinase like 1

MARK4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	MARK4	Q96L34	PRKCI	Homo sapiens	P41743	Anti Tag CoIP	14676191
Intra	MARK4	Q96L34	PARD6G	Homo sapiens	Q9BYG4	Anti Tag CoIP	14676191
Intra	MARK4	Q96L34	PNMA1	Homo sapiens	Q8ND90	Anti Tag CoIP	14676191
Intra	MARK4	Q96L34	TUBG1	Homo sapiens	P23258	Anti Tag CoIP	14676191
Intra	MARK4	Q96L34	TUBG1	Homo sapiens	P23258	Anti Tag CoIP	14594945
Intra	MARK4	Q96L34	TUBG1	Homo sapiens	P23258	TAP	14594945
Intra	MARK4	Q96L34	STK11	Homo sapiens	Q15831	Anti Tag CoIP	14676191
Intra	MARK4	Q96L34	YWHAH	Homo sapiens	Q04917	Anti Tag CoIP	14676191
Intra	MARK4	Q96L34	YWHAH	Homo sapiens	Q04917	Anti Tag CoIP	16959763
Intra	MARK4	Q96L34	LYN	Homo sapiens	P07948	Validated Y2H	32814053
Intra	MARK4	Q96L34	LYN	Homo sapiens	P07948	Y2H Array	32814053
Intra	MARK4	Q96L34	LYN	Homo sapiens	P07948	Y2H Pooling	32814053
Intra	MARK4	Q96L34	CDC42	Homo sapiens	P60953	Anti Tag CoIP	14676191
Intra	MARK4	Q96L34	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	25416956
Intra	MARK4	Q96L34	KRT31	Homo sapiens	Q15323	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Peutz-Jeghers Syndrome	PJS Polyposis, Hamartomatous Intestinal Polyps-And-Spots Syndrome Lentiginosis, Perioral Periorificial Lentiginosis Syndrome Hamartomatous Intestinal Polyposis Hamartomatous Polyp Colonic Hamartomatous Polyp Gastric Peutz-Jeghers Polyp Peutz Jeghers Colon Polyp Peutz Jeghers Polyp Peutz-Jeghers Polyp Of Small Intestine Peutz-Jeghers Small Bowel Hamartoma Peutz Jeghers Polyposis Intestinal Polyposis-Cutaneous Pigmentation Syndrome Peutz-Jeghers Polyposis Polyposis, Intestinal, Ii Intestinal Hamartomatous Polyposis Peutz-Jeghers Polyp Peutz-Jeghers Polyp Of The Stomach Peutz Jehgers Polyp Peutz-Jeghers Polyps Of Small Bowel
Parkinson Disease 6, Autosomal Recessive Early-Onset	Autosomal Recessive Early-Onset Parkinson Disease 6 Parkinson Disease 6 PARK6 Parkinson Disease 6, Early Onset Parkinson'S Disease 6 Parkinson Disease 6, Early-Onset Autosomal Recessive Early-Onset Parkinson'S Disease 6 Early-Onset Parkinson Disease 6 Autosomal Recessive Early-Onset Parkinson Disease Type 6 Parkinson Disease 6 Early-Onset Parkinson Disease 6 Late-Onset Susceptibility To Parkinson Disease Autosomal Recessive Early-Onset Digenic Pink1/Dj1 Parkinsonism Young Adult Onset Parkinson Disease, Autosomal Recessive Early-Onset, Digenic, Pink1/Dj1 Parkinson Disease, Type 6, Autosomal Recessive, Early-Onset
Alzheimer'S Disease 1	Alzheimer Disease Type 1 Alzheimer'S Disease 1, Early Onset
Hermansky-Pudlak Syndrome 1	Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells HPS1 Delta Storage Pool Disease Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Hermansky-Pudlak Syndrome, Type 1 Platelet Storage Pool Deficiency

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-139604	PCC0208017		99.52%	Unkown
HY-148065	FMF-06-098-1	Inhibitor	98.77%	Unkown
HY-114317	MARK4 inhibitor 1		98.29%	Unkown
HY-148062	RSS0680	Degrader	99.85%	Unkown
HY-154986	MARK4 inhibitor 2	Inhibitor	99.60%	Unkown
HY-154987	MARK4 inhibitor 3		98.23%	Unkown
HY-154988	MARK4 inhibitor 4		99.23%	Unkown
HY-RS08152	MARK4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18182	Mark4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24656	Mark4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	MARK4	VGNC	VGNC:74508
Bos taurus	MARK4	VGNC	VGNC:52203
Mus musculus	MARK4	MGD	MGI:1920955
Canis familiaris	MARK4	VGNC	VGNC:43026
Rattus norvegicus	MARK4	RGD	RGD:1591792
Felis catus	MARK4	VGNC	VGNC:63390
Others	MARK4	NCBI