STAC2 - SH3 and cysteine rich domain 2 Gene

Also Known as 24b2; 24b2/STAC2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 342667

About STAC2

This gene has 2 transcripts (splice variants), 238 orthologues and 2 paralogues. Biased expression in brain (RPKM 11.7), kidney (RPKM 2.2) and 3 other tissues.

Summary

This gene encodes a protein containing an SH3 domain and a zinc finger domain. The encoded protein has been shown to regulate Calcium Channel inactivation in a human cell line. Reduced expression of this gene has been observed in human heart failure. [provided by RefSeq, May 2017]

STAC2 Products (2)

mRNA Protein Name
NM_001351360.2 NP_001338289.1 SH3 and cysteine-rich domain-containing protein 2 isoform 2
NM_198993.5 NP_945344.1 SH3 and cysteine-rich domain-containing protein 2 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16713569 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STAC2 Protein Structure

C1_1

C1_1: Phorbol esters/diacylglycerol binding domain (C1 domain) (111 - 157)

SH3_9

SH3_9: Variant SH3 domain (299 - 347)

  • 0
  • 100
  • 200
  • 300
  • 411 a.a.
Protein Preferred Names Protein Names

SH3 and cysteine-rich domain-containing protein 2

  • SRC homology 3 and cysteine-rich domain-containing protein 2

STAC2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
STAC2 Q6ZMT1 LNX1 Homo sapiens Q8TBB1
Validated Y2H
25416956
Intra
STAC2 Q6ZMT1 LNX1 Homo sapiens Q8TBB1
Y2H Prey Pooling
25416956
Intra
STAC2 Q6ZMT1 ATXN1 Homo sapiens P54253
Y2H
16713569
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Childhood-Onset Schizophrenia

  • Childhood Schizophrenia

  • Schizophrenia, Childhood
Myopathy, Congenital, Bailey-Bloch

  • Native American Myopathy

  • Nam

  • MYPBB

  • Myopathy, Congenital, Baily-Bloch

  • Anti-Hmg-Coa Myopathy

  • Anti-Srp Myopathy

  • Autoimmune Necrotizing Myositis

  • Imnm

  • Immune Myopathy With Myocyte Necrosis

  • Immune-Mediated Necrotizing Myopathy

  • Myopathy, Congenital, With Myopathic Facies, Scoliosis, And Malignant Hyperthermia

  • Necrotizing Autoimmune Myopathy

  • Congenital Myopathy-Cleft Palate-Malignant Hyperthermia Syndrome

  • Congenital Myopathy With Cleft Palate And Malignant Hyperthermia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13864 STAC2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus STAC2 MGD MGI:2144518
Felis catus STAC2 VGNC VGNC:65742
Canis familiaris STAC2 VGNC VGNC:46871
Bos taurus STAC2 VGNC VGNC:35351
Rattus norvegicus STAC2 RGD RGD:1305548
Macaca mulatta STAC2 VGNC VGNC:77979
Others STAC2 NCBI