Napa - N-ethylmaleimide sensitive fusion protein attachment protein alpha Gene

Mus musculus

Also known as hyh; RA81; SNAPA; SNARE; a-SNAP; SNAP-alpha; 1500039N14Rik

Gene ID: 108124 | Gene type: protein coding

About Napa

Summary

Enables syntaxin binding activity. Involved in regulation of synaptic vesicle priming and synaptic vesicle priming. Acts upstream of or within several processes, including SNARE complex disassembly; apical protein localization; and nervous system development. Located in glutamatergic synapse. Part of synaptobrevin 2-SNAP-25-syntaxin-1a complex. Is expressed in central nervous system; peripheral nervous system ganglion; and retina. Orthologous to human NAPA (NSF attachment protein alpha). [provided by Alliance of Genome Resources, Apr 2022]

Napa Products(1)

mRNA	Protein	Name
NM_025898.4	NP_080174.1	alpha-soluble NSF attachment protein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21040848	MGI
enables syntaxin binding	IDA IDA: Inferred from direct assay	14755058	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within SNARE complex disassembly	IGI IGI: Inferred from genetic interaction	21040848	MGI
acts upstream of or within apical protein localization	IMP IMP: Inferred from mutant phenotype	14758363	MGI
acts upstream of or within brain development	IMP IMP: Inferred from mutant phenotype	11706940	MGI
acts upstream of or within intracellular protein transport	IMP IMP: Inferred from mutant phenotype	14755058	MGI
acts upstream of or within neuron differentiation	IMP IMP: Inferred from mutant phenotype	14758363	MGI
involved in regulation of synaptic vesicle priming	IDA IDA: Inferred from direct assay	21040848	MGI
involved in regulation of synaptic vesicle priming	IEP IEP: Inferred from expression pattern	21040848	MGI
acts upstream of or within regulation of synaptic vesicle priming	IGI IGI: Inferred from genetic interaction	21040848	MGI
involved in regulation of synaptic vesicle priming	IMP IMP: Inferred from mutant phenotype	21040848	MGI
acts upstream of or within synaptic transmission, glutamatergic	IGI IGI: Inferred from genetic interaction	21040848	MGI
involved in synaptic vesicle priming	IDA IDA: Inferred from direct assay	21040848	MGI
involved in synaptic vesicle priming	IMP IMP: Inferred from mutant phenotype	21040848	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	21040848	MGI
is active in glutamatergic synapse	IEP IEP: Inferred from expression pattern	21040848	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	21040848	MGI
part of synaptobrevin 2-SNAP-25-syntaxin-1a complex	IDA IDA: Inferred from direct assay	21040848	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

alpha-soluble NSF attachment protein

N-ethylmaleimide-sensitive factor attachment protein alpha

hydrocephaly with hop gait

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B1109	N-Acetylprocainamide	Inhibitor	99.89%	Yes

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-101433	N-Acetylprocainamide hydrochloride	Inhibitor	99.83%	Yes
HY-RS09029	NAPA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS09034	NAPSA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18143	Napa Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24618	Napa Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Napa	NCBI	NCBI:8775

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