Napa - N-ethylmaleimide sensitive fusion protein attachment protein alpha Gene

Also Known as hyh; RA81; SNAPA; SNARE; a-SNAP; SNAP-alpha; 1500039N14Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 108124

Summary

Enables syntaxin binding activity. Involved in regulation of synaptic vesicle priming and synaptic vesicle priming. Acts upstream of or within several processes, including SNARE complex disassembly; apical protein localization; and nervous system development. Located in glutamatergic synapse. Part of synaptobrevin 2-SNAP-25-syntaxin-1a complex. Is expressed in central nervous system; peripheral nervous system ganglion; and retina. Orthologous to human NAPA (NSF attachment protein alpha). [provided by Alliance of Genome Resources, Apr 2022]

Napa Products (1)

mRNA	Protein	Name
NM_025898.4	NP_080174.1	alpha-soluble NSF attachment protein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21040848	MGI
enables syntaxin binding	IDA IDA: Inferred from direct assay	14755058	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within SNARE complex disassembly	IGI IGI: Inferred from genetic interaction	21040848	MGI
acts upstream of or within apical protein localization	IMP IMP: Inferred from mutant phenotype	14758363	MGI
acts upstream of or within brain development	IMP IMP: Inferred from mutant phenotype	11706940	MGI
acts upstream of or within intracellular protein transport	IMP IMP: Inferred from mutant phenotype	14755058	MGI
acts upstream of or within neuron differentiation	IMP IMP: Inferred from mutant phenotype	14758363	MGI
involved in regulation of synaptic vesicle priming	IDA IDA: Inferred from direct assay	21040848	MGI
involved in regulation of synaptic vesicle priming	IEP IEP: Inferred from expression pattern	21040848	MGI
acts upstream of or within regulation of synaptic vesicle priming	IGI IGI: Inferred from genetic interaction	21040848	MGI
involved in regulation of synaptic vesicle priming	IMP IMP: Inferred from mutant phenotype	21040848	MGI
acts upstream of or within synaptic transmission, glutamatergic	IGI IGI: Inferred from genetic interaction	21040848	MGI
involved in synaptic vesicle priming	IDA IDA: Inferred from direct assay	21040848	MGI
involved in synaptic vesicle priming	IMP IMP: Inferred from mutant phenotype	21040848	MGI

Cellular Component GO Annotation	Evidence	References	Source
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	21040848	MGI
is active in glutamatergic synapse	IEP IEP: Inferred from expression pattern	21040848	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	21040848	MGI
part of synaptobrevin 2-SNAP-25-syntaxin-1a complex	IDA IDA: Inferred from direct assay	21040848	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
alpha-soluble NSF attachment protein	N-ethylmaleimide-sensitive factor attachment protein alpha hydrocephaly with hop gait

Related Agents

Approval
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B1109	N-Acetylprocainamide	Inhibitor	99.89%	Yes

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-101433	N-Acetylprocainamide hydrochloride	Inhibitor	99.83%	Yes
HY-RS09029	NAPA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS09034	NAPSA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18143	Napa Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24618	Napa Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Napa	NCBI	NCBI:8775