NAPA - NSF attachment protein alpha Gene

Also Known as SNAPA

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8775

About NAPA

Cytogenetic location: 19q13.32-q13.33 Genomic coordinates (GRCh38): 19:47,484,530-47,515,063 (from NCBI)

This gene has 22 transcripts (splice variants), 222 orthologues and 2 paralogues. Ubiquitous expression in prostate (RPKM 53.4), adrenal (RPKM 52.5) and 25 other tissues.

Summary

This gene encodes a member of the soluble NSF attachment protein (SNAP) family. SNAP proteins play a critical role in the docking and fusion of vesicles to target membranes as part of the 20S NSF-SNAP-SNARE complex. The encoded protein plays a role in the completion of membrane fusion by mediating the interaction of N-ethylmaleimide-sensitive factor (NSF) with the vesicle-associated and membrane-associated SNAP receptor (SNARE) complex, and stimulating the ATPase activity of NSF. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jun 2011]

NAPA Products (1)

mRNA	Protein	Name
NM_003827.4	NP_003818.2	alpha-soluble NSF attachment protein

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15029241	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NAPA Protein Structure

SNAP

0
100
200
295 a.a.

Protein Preferred Names	Protein Names
alpha-soluble NSF attachment protein	N-ethylmaleimide-sensitive factor attachment protein, alpha

NAPA Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	NAPA	P54920	NSF	Homo sapiens	P46459	Pull Down	30833792
Intra	NAPA	P54920	NSF	Homo sapiens	P46459	Anti Tag CoIP	35271311
Intra	NAPA	P54920	STX5	Homo sapiens	Q13190	Anti Tag CoIP	33961781
Intra	NAPA	P54920	STX5	Homo sapiens	Q13190	Pull Down	30833792
Intra	NAPA	P54920	STX5	Homo sapiens	Q13190	Anti Tag CoIP	35271311
Intra	NAPA	P54920	STX4	Homo sapiens	Q12846	Anti Tag CoIP	33961781
Intra	NAPA	P54920	STX4	Homo sapiens	Q12846	Pull Down	30833792
Intra	NAPA	P54920	STX4	Homo sapiens	Q12846	Pull Down	16189514
Intra	NAPA	P54920	STX4	Homo sapiens	Q12846	Anti Tag CoIP	35271311
Intra	NAPA	P54920	SNAP23	Homo sapiens	O00161	Anti Tag CoIP	33961781
Intra	NAPA	P54920	SNAP23	Homo sapiens	O00161	Pull Down	30833792
Intra	NAPA	P54920	SNAP23	Homo sapiens	O00161	Anti Tag CoIP	35271311
Intra	NAPA	P54920	SNAP23	Homo sapiens	O00161	Pull Down	16189514

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant NAPA Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71326	SNAP-alpha Protein, Human (His)	P54920 (M1-R295)	≥ 95%, as determined by reducing SDS-PAGE.

NAPA Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83130	SNAP alpha Antibody (YA2875)	WB, IHC-P, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Tetanus	Lockjaw Clostridial Tetanus Infection Due To Clostridium Tetani Lock-Jaw
Polyomavirus-Associated Nephropathy	Polyomavirus Associated Nephropathy Pvan

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B1109	N-Acetylprocainamide	Inhibitor	99.89%	Yes

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-101433	N-Acetylprocainamide hydrochloride	Inhibitor	99.83%	Yes
HY-RS09029	NAPA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS09034	NAPSA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18143	Napa Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24618	Napa Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	NAPA	VGNC	VGNC:68414
Rattus norvegicus	NAPA	RGD	RGD:620855
Macaca mulatta	NAPA	VGNC	VGNC:75131
Canis familiaris	NAPA	VGNC	VGNC:43619
Mus musculus	NAPA	MGD	MGI:104563
Bos taurus	NAPA	VGNC	VGNC:31881
Others	NAPA	NCBI