CPLX2 - complexin 2 Gene

Also Known as CPX2; Hfb1; 921-L; CPX-2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10814

About CPLX2

Cytogenetic location: 5q35.2 Genomic coordinates (GRCh38): 5:175,796,533-175,884,021 (from NCBI)

This gene has 10 transcripts (splice variants), 115 orthologues and 3 paralogues. Biased expression in brain (RPKM 63.0) and adrenal (RPKM 12.1).

Summary

Proteins encoded by the complexin/synaphin gene family are cytosolic proteins that function in synaptic vesicle exocytosis. These proteins bind syntaxin, part of the SNAP receptor. The protein product of this gene binds to the SNAP receptor complex and disrupts it, allowing transmitter release. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

CPLX2 Products (2)

mRNA	Protein	Name
NM_001008220.2	NP_001008221.1	complexin-2
NM_006650.4	NP_006641.1	complexin-2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CPLX2 Protein Structure

Synaphin

0
100
134 a.a.

Protein Preferred Names	Protein Names
complexin-2	CPX II

CPLX2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CPLX2	Q6PUV4	NDRG4	Homo sapiens	Q9ULP0-2	Validated Y2H	32296183
Intra	CPLX2	Q6PUV4	MYG1	Homo sapiens	Q9HB07	Validated Y2H	32296183
Intra	CPLX2	Q6PUV4	PBX3	Homo sapiens	Q96AL5	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CPLX2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76282	CPLX2/Complexin-2 Protein, Human (His)	Q6PUV4 (D2-K134)	≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Lacrimal Gland Carcinoma	Lacrimal Gland Cancer Carcinoma Of The Lacrimal Gland Malignant Neoplasm Of Lacrimal Gland Malignant Tumour Of Lacrimal Gland Neoplasm Of Lacrimal Gland Tumor Of The Lacrimal Gland Malignant Tumor Of Lacrimal Gland
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1
Epilepsy, Familial Temporal Lobe, 7	Familial Temporal Lobe Epilepsy 7 ETL7 Epilepsy, Temporal Lobe, Familial, Type 7
Lacrimal Gland Adenoid Cystic Carcinoma	Adenoid Cystic Carcinoma Of Lacrimal Gland
Lacrimal Gland Adenocarcinoma	Adenocarcinoma Of Lacrimal Gland
Huntington Disease	Huntington'S Disease Huntington Chorea Huntington'S Chorea HD Huntington Chronic Progressive Hereditary Chorea Juvenile Huntington Disease Chronic Progressive Chorea Chronic Progressive Hereditary Chorea Hc - [Huntington Chorea] Hereditary Chorea Progressive Hereditary Chorea

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03098	CPLX2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19182	Cplx2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25670	Cplx2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CPLX2	VGNC	VGNC:27652
Canis familiaris	CPLX2	VGNC	VGNC:39556
Mus musculus	CPLX2	MGD	MGI:104726
Rattus norvegicus	CPLX2	RGD	RGD:70945
Felis catus	CPLX2	VGNC	VGNC:102182
Others	CPLX2	NCBI