SUB1 - SUB1 regulator of transcription Gene
Also Known as P15; PC4; p14
Species: Homo sapiens
About SUB1
This gene has 13 transcripts (splice variants) and 228 orthologues. Ubiquitous expression in brain (RPKM 41.5), fat (RPKM 34.4) and 25 other tissues.
Summary
Enables identical protein binding activity; single-stranded DNA binding activity; and transcription coactivator activity. Involved in negative regulation of DNA metabolic process and regulation of transcription by RNA polymerase II. Located in nucleolus and nucleoplasm. Part of transcription regulator complex. [provided by Alliance of Genome Resources, Apr 2022]
SUB1 Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_006713.4 | NP_006704.3 | activated RNA polymerase II transcriptional coactivator p15 |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables identical protein binding |
IPI
IPI: Inferred from physical interaction
|
16415882 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
9847329 | GOA |
| enables single-stranded DNA binding |
IDA
IDA: Inferred from direct assay
|
8062391 | GOA |
| enables transcription coactivator activity |
IDA
IDA: Inferred from direct assay
|
8062391 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in RNA polymerase II promoter clearance |
IDA
IDA: Inferred from direct assay
|
25308091 | GOA |
| involved in negative regulation of DNA duplex unwinding |
IDA
IDA: Inferred from direct assay
|
16605275 | GOA |
| involved in negative regulation of DNA metabolic process |
IDA
IDA: Inferred from direct assay
|
28369605 | GOA |
| involved in regulation of transcription by RNA polymerase II |
IDA
IDA: Inferred from direct assay
|
8062391 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| part of transcription regulator complex |
IDA
IDA: Inferred from direct assay
|
8062391 | GOA |
SUB1 Protein Structure
PC4: Transcriptional Coactivator p15 (PC4) (63 - 116)
- 0
- 100
- 127 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
activated RNA polymerase II transcriptional coactivator p15 |
|
SUB1 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
SUB1 | P53999 | CSTF2 | Homo sapiens | P33240-1 | 11389848 | |
|
Intra
|
SUB1 | P53999 | SUB1 | Homo sapiens | P53999 | 16415882 | |
|
Intra
|
SUB1 | P53999 | SUB1 | Homo sapiens | P53999 | 32296183 | |
|
Intra
|
SUB1 | P53999 | SUB1 | Homo sapiens | P53999 | 25416956 | |
|
Intra
|
SUB1 | P53999 | SUB1 | Homo sapiens | P53999 | 32296183 | |
|
Intra
|
SUB1 | P53999 | SUB1 | Homo sapiens | P53999 | 32296183 |
Recombinant SUB1 Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P74650 | PC4/SUB1 Protein, Human (His) | P53999 (M1-L127) | ≥ 95%, as determined by reducing SDS-PAGE. |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Dyskeratosis Congenita, Autosomal Recessive 5 |
|
|
| Tinea Manuum |
|
|
| Cri-Du-Chat Syndrome |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Mus musculus | SUB1 | MGD | MGI:104811 |
| Rattus norvegicus | SUB1 | RGD | RGD:621582 |
| Bos taurus | SUB1 | VGNC | VGNC:35454 |
| Macaca mulatta | SUB1 | VGNC | VGNC:110431 |
| Others | SUB1 | NCBI |