KLK11 - kallikrein related peptidase 11 Gene

Also Known as TLSP; PRSS20

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 11012

About KLK11

Cytogenetic location: 19q13.41 Genomic coordinates (GRCh38): 19:51,022,236-51,027,991 (from NCBI)

This gene has 11 transcripts (splice variants), 171 orthologues and 12 paralogues. Biased expression in esophagus (RPKM 58.7), skin (RPKM 44.2) and 7 other tissues.

Summary

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel Cancer and Other disease biomarkers. This gene is one of the fifteen Kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing and the use of alternate promoters results in multiple transcript variants encoding distinct isoforms which are differentially expressed. [provided by RefSeq, Dec 2016]

KLK11 Products (4)

mRNA Protein Name
NM_001136032.3 NP_001129504.1 kallikrein-11 isoform 1 precursor
NM_001167605.2 NP_001161077.1 kallikrein-11 isoform 3 precursor
NM_006853.3 NP_006844.1 kallikrein-11 isoform 1 precursor
NM_144947.3 NP_659196.1 kallikrein-11 isoform 2

KLK11 Protein Structure

Trypsin

Trypsin: Trypsin (54 - 275)

  • 0
  • 100
  • 200
  • 282 a.a.
Protein Preferred Names Protein Names

kallikrein-11

  • hK11

Recombinant KLK11 Proteins

Cat. No. Product Name Accession Purity
HY-P7381 Kallikrein-11 Protein, Human (sf9) Q9UBX7-2 (E51-N282) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P73263 Kallikrein-11 Protein, Human (HEK293, His) Q9UBX7-1 (E19-N250) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Chronic Ethmoiditis

  • Chronic Ethmoidal Sinusitis

  • Chronic Ethmoid Sinusitis

  • Ethmoidal Sinusitis - Chronic
Prostate Cancer

  • Prostate Carcinoma

  • Prostate Cancer, Familial

  • Prostate Neoplasm

  • Prostate Cancer, Somatic

  • Prostate Cancer, Susceptibility To

  • Prostatic Cancer

  • Prostatic Neoplasms

  • Hereditary Prostate Cancer

  • Prostatic Neoplasm

  • Cancer Of Prostate

  • Carcinoma Of Prostate

  • Familial Prostate Cancer

  • Familial Prostate Carcinoma

  • Malignant Tumor Of Prostate

  • Malignant Neoplasm Of Prostate

  • Prostate Cancer, Familial, Susceptibility To

  • Malignant Tumor Of The Prostate

  • Ngp - New Growth Of Prostate

  • Tumor Of The Prostate

  • Prostate Cancer, Hereditary

  • Cancer Of The Prostate

  • Malignant Neoplasm Of The Prostate

  • Prostatic Carcinoma

  • PC

  • Prca

  • Cancer, Prostate

  • Malignant Prostatic Tumour

  • Malignant Tumour Of Prostate

  • Primary Prostate Cancer

  • Primary Malignant Neoplasm Of Prostate

  • Prostate Gland Cancer
Asthma

  • Chronic Obstructive Asthma

  • Asthma, Diminished Response To Antileukotriene Treatment In

  • Bronchial Hyperreactivity

  • Asthma, Susceptibility To

  • Asthma, Bronchial

  • Asthma, Protection Against

  • Asthma, Nocturnal, Susceptibility To

  • Nocturnal Asthma

  • Asthma-Related Traits

  • Asthma-Related Traits, Susceptibility To

  • Asthma, Nocturnal

  • Chronic Obstructive Asthma With Acute Exacerbation

  • Chronic Obstructive Asthma With Status Asthmaticus

  • Exercise Induced Asthma

  • Exercise-Induced Asthma

  • Bronchial Asthma

  • Asthma, Exercise-Induced

  • Idiosyncratic Asthma

  • Unspecified Asthma With Acute Exacerbation

  • Asthma, Unspecified, With Stated Status Asthmaticus

  • Status Asthmaticus Nos

  • Acute Severe Asthma

  • Acute Severe Bronchial Asthma

  • Status Asthma

  • Status Post Asthmaticus
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07375 KLK11 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20974 Klk11 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27491 Klk11 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus KLK11 VGNC VGNC:67962
Mus musculus KLK11 MGD MGI:1929977
Canis familiaris KLK11 VGNC VGNC:42479
Bos taurus KLK11 VGNC VGNC:30673
Rattus norvegicus KLK11 RGD RGD:1308690
Others KLK11 NCBI