Tmbim6 - transmembrane BAX inhibitor motif containing 6 Gene

Also Known as Bi1; Tegt; 5031406P05Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 110213

Summary

Enables endoribonuclease inhibitor activity and enzyme binding activity. Involved in cellular response to unfolded protein; negative regulation of RNA metabolic process; and negative regulation of immunoglobulin production. Acts upstream of or within endoplasmic reticulum calcium ion homeostasis; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; and negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway. Predicted to be located in endoplasmic reticulum membrane and mitochondrial membrane. Is expressed in head and retina. Orthologous to human TMBIM6 (transmembrane Bax Inhibitor motif containing 6). [provided by Alliance of Genome Resources, Apr 2022]

Tmbim6 Products (4)

mRNA Protein Name
NM_001171034.1 NP_001164505.1 bax inhibitor 1
NM_001171035.1 NP_001164506.1 bax inhibitor 1
NM_001171036.1 NP_001164507.1 bax inhibitor 1
NM_026669.4 NP_080945.1 bax inhibitor 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables endoribonuclease inhibitor activity IMP
IMP: Inferred from mutant phenotype
19328063 MGI
enables enzyme binding IPI
IPI: Inferred from physical interaction
19328063 MGI
Biological Process GO Annotation Evidence References Source
involved in cellular response to unfolded protein IMP
IMP: Inferred from mutant phenotype
19328063 MGI
acts upstream of or within endoplasmic reticulum calcium ion homeostasis IDA
IDA: Inferred from direct assay
15304216 MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IDA
IDA: Inferred from direct assay
15304216 MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IMP
IMP: Inferred from mutant phenotype
15304216 MGI
involved in negative regulation of RNA splicing IMP
IMP: Inferred from mutant phenotype
19328063 MGI
acts upstream of or within negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IGI
IGI: Inferred from genetic interaction
22240901 MGI
involved in negative regulation of endoribonuclease activity IMP
IMP: Inferred from mutant phenotype
19328063 MGI
involved in negative regulation of immunoglobulin production IMP
IMP: Inferred from mutant phenotype
19328063 MGI
acts upstream of or within neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IMP
IMP: Inferred from mutant phenotype
15304216 MGI
involved in response to endoplasmic reticulum stress IMP
IMP: Inferred from mutant phenotype
21075086 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

bax inhibitor 1

  • BI-1

  • testis enhanced gene transcript

  • testis-enhanced gene transcript protein

  • transmembrane BAX inhibitor motif-containing protein 6

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-137175 TMBIM6 antagonist-1 Antagonist 98.92% Unkown
HY-161388 NSCLC-IN-1 Inducer / Unkown
HY-RS14620 TMBIM6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19822 Tmbim6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26318 Tmbim6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tmbim6 NCBI NCBI:7009