Acat2 - acetyl-Coenzyme A acetyltransferase 2 Gene

Also Known as Tcp-1x; Tcp1-rs1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 110460

About Acat2

Chromosome 17: 13,161,777-13,179,634 reverse strand.GRCm39:CM001010.3

This gene has 4 transcripts (splice variants), 212 orthologues, 6 paralogues and is associated with 12 phenotypes. Ubiquitous expression in CNS E11.5 (RPKM 65.2), liver adult (RPKM 62.8) and 28 other tissues.

Summary

Predicted to enable acetyl-CoA C-acetyltransferase activity. Involved in positive regulation of intestinal Cholesterol absorption. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in coronary artery disease. Orthologous to human ACAT2 (acetyl-CoA acetyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]

Acat2 Products (1)

mRNA Protein Name
NM_009338.3 NP_033364.2 acetyl-CoA acetyltransferase, cytosolic

Acat2 Protein Structure

PRK05790

PRK05790: PRK05790 (7 - 395)

  • 0
  • 100
  • 200
  • 300
  • 397 a.a.
Protein Preferred Names Protein Names

acetyl-CoA acetyltransferase, cytosolic

  • cytosolic acetoacetyl-CoA thiolase

  • t-complex protein 1, related sequence 1

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Phase
HY-13215 Avasimibe Inhibitor 99.85% Phase 3
HY-100401 Pactimibe Inhibitor 99.98% Phase 3
HY-100401A Pactimibe sulfate Inhibitor 98.0% Phase 3
HY-100400A K-604 dihydrochloride Inhibitor 99.42% Phase 2
HY-100399A Nevanimibe hydrochloride Inhibitor 99.49% Phase 2
HY-100399 Nevanimibe Inhibitor 98.99% Phase 2

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N18066 Esculeogenin A Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Acat2 NCBI NCBI:39