Srsf1 - serine and arginine-rich splicing factor 1 Gene

Also Known as Asf; Sf2; Sfrs1; 1110054N12Rik; 5730507C05Rik; 6330415C05Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 110809

Summary

The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding Other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]

Srsf1 Products (2)

mRNA Protein Name
NM_001078167.2 NP_001071635.1 serine/arginine-rich splicing factor 1 isoform 2
NM_173374.4 NP_775550.2 serine/arginine-rich splicing factor 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RS domain binding IPI
IPI: Inferred from physical interaction
15798186 MGI
enables mRNA binding IMP
IMP: Inferred from mutant phenotype
21822258 MGI
enables molecular function regulator activity IDA
IDA: Inferred from direct assay
21822258 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
20477871 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within RNA splicing IDA
IDA: Inferred from direct assay
15798186 MGI
acts upstream of or within RNA splicing IGI
IGI: Inferred from genetic interaction
15652482 MGI
acts upstream of or within cardiac muscle contraction IGI
IGI: Inferred from genetic interaction
15652482 MGI
involved in cellular response to interleukin-17 IDA
IDA: Inferred from direct assay
29563620 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
15652482 MGI
involved in interleukin-17-mediated signaling pathway IDA
IDA: Inferred from direct assay
21822258 MGI
involved in interleukin-17-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
21822258 MGI
involved in mRNA stabilization IDA
IDA: Inferred from direct assay
21822258 MGI
involved in mRNA stabilization IMP
IMP: Inferred from mutant phenotype
21822258 MGI
involved in protein localization to P-body IDA
IDA: Inferred from direct assay
29563620 MGI
involved in protein localization to nucleus IDA
IDA: Inferred from direct assay
29563620 MGI
involved in regulation of RNA splicing IMP
IMP: Inferred from mutant phenotype
28785060 MGI
involved in signal transduction involved in regulation of gene expression IDA
IDA: Inferred from direct assay
21822258 MGI
involved in signal transduction involved in regulation of gene expression IMP
IMP: Inferred from mutant phenotype
21822258 MGI
Cellular Component GO Annotation Evidence References Source
located in nuclear speck IDA
IDA: Inferred from direct assay
20729808 MGI
located in nucleus IDA
IDA: Inferred from direct assay
15615787 MGI
is active in nucleus IPI
IPI: Inferred from physical interaction
29563620 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

serine/arginine-rich splicing factor 1

  • ASF/SF2

  • pre-mRNA-splicing factor SRp30a

  • splicing factor, arginine/serine-rich 1 (ASF/SF2)

Srsf1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Srsf1 Q6PDM2 Polr2a Mus musculus P08775
Anti Tag CoIP
23663783
Intra
Srsf1 Q6PDM2 Traf5 Mus musculus P70191
Anti Bait CoIP
21822258
Intra
Srsf1 Q6PDM2 Hexim1 Mus musculus Q8R409
Anti Tag CoIP
23663783
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-117661 SPHINX31 Inhibitor 99.25% Unkown
HY-P5960 PTBP1-RNA-binding inhibitor P6 TFA 98.59% Unkown
HY-170935 SRSF1-IN-1 / Unkown
HY-125201 Indazole 1 Inhibitor / Unkown
HY-183831 GPS167 / Unkown
HY-E70660 CDK13/CycK Recombinant Human Active Protein Kinase / Unkown
HY-RS13790 SRSF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17174 Srsf1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23624 Srsf1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Srsf1 NCBI NCBI:6426