SRSF1 - serine and arginine rich splicing factor 1 Gene

Also Known as ASF; SF2; SFRS1; SF2p33; SRp30a

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6426

About SRSF1

Cytogenetic location: 17q22 Genomic coordinates (GRCh38): 17:57,989,038-58,007,246 (from NCBI)

This gene has 9 transcripts (splice variants), 239 orthologues, 8 paralogues and is associated with 1 phenotype. Ubiquitous expression in lymph node (RPKM 44.8), appendix (RPKM 40.8) and 25 other tissues.

Summary

This gene encodes a member of the arginine/serine-rich splicing factor protein family. The encoded protein can either activate or repress splicing, depending on its phosphorylation state and its interaction partners. Multiple transcript variants have been found for this gene. There is a pseudogene of this gene on chromosome 13. [provided by RefSeq, Jun 2014]

SRSF1 Products (2)

mRNA	Protein	Name
NM_001078166.2	NP_001071634.1	serine/arginine-rich splicing factor 1 isoform 2
NM_006924.5	NP_008855.1	serine/arginine-rich splicing factor 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA topoisomerase binding	IPI IPI: Inferred from physical interaction	9611241	GOA
enables RNA binding	IDA IDA: Inferred from direct assay	19561594	GOA
enables RNA binding	IPI IPI: Inferred from physical interaction	20797886	GOA
enables mRNA binding	IDA IDA: Inferred from direct assay	21984414	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9237760	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in alternative mRNA splicing, via spliceosome	IDA IDA: Inferred from direct assay	8940107	GOA
involved in mRNA 5'-splice site recognition	IDA IDA: Inferred from direct assay	8940107	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of catalytic step 2 spliceosome	IDA IDA: Inferred from direct assay	11991638	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	24449914	GOA
part of exon-exon junction complex	IDA IDA: Inferred from direct assay	16314458	GOA
located in nuclear speck	IDA IDA: Inferred from direct assay	20797886	GOA
located in nucleoplasm	IDA IDA: Inferred from direct assay	9885563	GOA
located in nucleus	IDA IDA: Inferred from direct assay	21984414	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SRSF1 Protein Structure

RRM_1

0
100
200
248 a.a.

Protein Preferred Names	Protein Names
serine/arginine-rich splicing factor 1	SR splicing factor 1

SRSF1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SRSF1	Q07955	SNRNP70	Homo sapiens	P08621	Anti Tag CoIP	33961781
Intra	SRSF1	Q07955	NXF1	Homo sapiens	Q9UBU9	Pull Down	15184380
Intra	SRSF1	Q07955	NXF1	Homo sapiens	Q9UBU9	Y2H	21988832
Intra	SRSF1	Q07955	NXF1	Homo sapiens	Q9UBU9	CoIP	15184380
Intra	SRSF1	Q07955	TRAF5	Homo sapiens	O00463	Anti Tag CoIP	21822258
Intra	SRSF1	Q07955	SRPK1	Homo sapiens	Q96SB4	Affinity Chrom	10196197
Intra	SRSF1	Q07955	SRPK1	Homo sapiens	Q96SB4	Protein Kinase Assay	23602568
Intra	SRSF1	Q07955	SRPK2	Homo sapiens	P78362	Anti Tag CoIP	33961781
Intra	SRSF1	Q07955	SRPK2	Homo sapiens	P78362	Protein Kinase Assay	23602568
Cross	SRSF1	Q07955	Srpk1	Mus musculus	O70551	Far-WB	10196197
Cross	SRSF1	Q07955	Srpk1	Mus musculus	O70551	Anti Tag CoIP	10196197
Intra	SRSF1	Q07955	CIR1	Homo sapiens	Q86X95	Y2H	15652350
Intra	SRSF1	Q07955	CIR1	Homo sapiens	Q86X95	Anti Tag CoIP	15652350
Intra	SRSF1	Q07955	TRA2B	Homo sapiens	P62995	Y2H Array	32296183
Intra	SRSF1	Q07955	TRA2B	Homo sapiens	P62995	Y2H Prey Pooling	32296183
Intra	SRSF1	Q07955	U2AF2	Homo sapiens	P26368	Anti Tag CoIP	33961781
Intra	SRSF1	Q07955	U2AF2	Homo sapiens	P26368	Y2H Pooling	16189514

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SRSF1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P700524	SRSF1 Protein, Human (His-SUMO)	Q07955-1 (S2-T248)	≥ 95%, as determined by reducing SDS-PAGE.

SRSF1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82191	SF2 Antibody (YA1936)	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat
HY-P82191A	SF2 Antibody (YA1936)(PBS only)	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Homocystinuria	Cystathionine Beta Synthase Deficiency Homocysteinemia Cbs Deficiency Cystathionine Synthase Deficiency Cystathionine Beta-Synthase Deficiency Disease
Retinal Melanoma	Malignant Retinal Melanoma Malignant Melanoma Of Retina
Xeroderma Pigmentosum, Complementation Group D	Xeroderma Pigmentosum, Group D Xpdc Xeroderma Pigmentosum Iv XPD Xeroderma Pigmentosum Group D Xeroderma Pigmentosum Viii Xp Group D Xp Group H Xp4 Xp8 Xph Xp, Group D Xp4 Xeroderma Pigmentosum Viii, Formerly Xp8, Formerly Xp, Group H, Formerly Xph, Formerly Xeroderma Pigmentosum Complementation Group D XP-D Xp-D/Cs
Unilateral Focal Polymicrogyria
Deafness, Autosomal Recessive 110	DFNB110 Autosomal Recessive Nonsyndromic Deafness 110 Autosomal Recessive Deafness 110 Deafness, Autosomal Recessive, 110
Trichothiodystrophy	Ttd Amish Brittle Hair Syndrome Bids Syndrome Brittle Hair-Intellectual Impairment-Decreased Fertility-Short Stature Syndrome Ibids Pibids Trichothiodystrophy Syndromes
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-117661	SPHINX31	Inhibitor	99.25%	Unkown
HY-P5960	PTBP1-RNA-binding inhibitor P6 TFA		98.59%	Unkown
HY-170935	SRSF1-IN-1		/	Unkown
HY-125201	Indazole 1	Inhibitor	/	Unkown
HY-183831	GPS167		/	Unkown
HY-E70660	CDK13/CycK Recombinant Human Active Protein Kinase		/	Unkown
HY-RS13790	SRSF1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17174	Srsf1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23624	Srsf1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	SRSF1	VGNC	VGNC:99464
Mus musculus	SRSF1	MGD	MGI:98283
Canis familiaris	SRSF1	VGNC	VGNC:46816
Rattus norvegicus	SRSF1	RGD	RGD:1587490
Bos taurus	SRSF1	VGNC	VGNC:35297
Others	SRSF1	NCBI