CIR1 - corepressor interacting with RBPJ, CIR1 Gene

Homo sapiens

Also known as CIR

Gene ID: 9541 | Gene type: protein coding

About CIR1

Cytogenetic location: 2q31.1 Genomic coordinates (GRCh38): 2:174,348,022-174,395,712 (from NCBI)

This gene has 5 transcripts (splice variants) and 197 orthologues. Ubiquitous expression in bone marrow (RPKM 20.7), testis (RPKM 18.7) and 25 other tissues.

Summary

Enables histone deacetylase binding activity; protein kinase binding activity; and transcription corepressor activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in nuclear speck. Part of protein-containing complex. Colocalizes with centrosome. [provided by Alliance of Genome Resources, Apr 2022]

CIR1 Products(1)

mRNA	Protein	Name
NM_004882.4	NP_004873.3	corepressor interacting with RBPJ 1

CIR1 Protein Structure

Cir_N

0
100
200
300
400
450 a.a.

Protein Preferred Names

Protein Names

corepressor interacting with RBPJ 1

CBF1 (RBPJ) interacting corepressor 1

Related Diseases

Diseases

Alias

Neurodermatitis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02720	CIR1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CIR1	RGD	RGD:1309199
Felis catus	CIR1	VGNC	VGNC:60907
Macaca mulatta	CIR1	VGNC	VGNC:71331
Mus musculus	CIR1	MGD	MGI:1914185
Bos taurus	CIR1	VGNC	VGNC:59328