2. Gene
  3. PTP4A3 - protein tyrosine phosphatase 4A3 Gene

PTP4A3 - protein tyrosine phosphatase 4A3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as PRL3; PRL-3; PRL-R

Gene ID: 11156 | Gene type: protein coding

About PTP4A3

Cytogenetic location: 8q24.3 Genomic coordinates (GRCh38): 8:141,392,021-141,432,454 (from NCBI)

This gene has 8 transcripts (splice variants), 1 gene allele, 211 orthologues and 8 paralogues. Broad expression in heart (RPKM 28.7), prostate (RPKM 11.1) and 20 other tissues.

Summary

This gene encodes a member of the protein-tyrosine Phosphatase family. Protein tyrosine phosphatases are cell signaling molecules that play regulatory roles in a variety of cellular processes. Studies of this class of protein tyrosine Phosphatase in mice demonstrates that they are prenylated in vivo, suggesting their association with cell plasma membrane. The encoded protein may enhance cell proliferation, and overexpression of this gene has been implicated in tumor metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

PTP4A3 Products(2)

mRNA Protein Name
NM_007079.3 NP_009010.2 protein tyrosine phosphatase type IVA 3 isoform 2
NM_032611.3 NP_116000.1 protein tyrosine phosphatase type IVA 3 isoform 1

PTP4A3 Protein Structure

Y_phosphatase

Y_phosphatase: Protein-tyrosine phosphatase (42 - 147)

  • 0
  • 100
  • 173 a.a.
Protein Preferred Names Protein Names

protein tyrosine phosphatase type IVA 3

phosphatase of regenerating liver 3

Recombinant PTP4A3 Proteins

Cat. No. Product Name Accession Purity
HY-P701033 PTP4A3 Protein, Human (His) O75365-1 (M1-C170) ≥95%

Related Diseases

Diseases Alias
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-135457 JMS-053 ≥98.0% Unkown
HY-RS11411 PTP4A3 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta PTP4A3 VGNC VGNC:76596
Mus musculus PTP4A3 MGD MGI:1277098
Canis familiaris PTP4A3 VGNC VGNC:45163
Felis catus PTP4A3 VGNC VGNC:81706
Bos taurus PTP4A3 VGNC VGNC:33525
Rattus norvegicus PTP4A3 RGD RGD:1308687
Others PTP4A3 NCBI