PTP4A3 - protein tyrosine phosphatase 4A3 Gene

Also Known as PRL3; PRL-3; PRL-R

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 11156

About PTP4A3

Cytogenetic location: 8q24.3 Genomic coordinates (GRCh38): 8:141,392,021-141,432,454 (from NCBI)

This gene has 8 transcripts (splice variants), 1 gene allele, 211 orthologues and 8 paralogues. Broad expression in heart (RPKM 28.7), prostate (RPKM 11.1) and 20 other tissues.

Summary

This gene encodes a member of the protein-tyrosine Phosphatase family. Protein tyrosine phosphatases are cell signaling molecules that play regulatory roles in a variety of cellular processes. Studies of this class of protein tyrosine Phosphatase in mice demonstrates that they are prenylated in vivo, suggesting their association with cell plasma membrane. The encoded protein may enhance cell proliferation, and overexpression of this gene has been implicated in tumor metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

PTP4A3 Products (2)

mRNA Protein Name
NM_007079.3 NP_009010.2 protein tyrosine phosphatase type IVA 3 isoform 2
NM_032611.3 NP_116000.1 protein tyrosine phosphatase type IVA 3 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
23178297 GOA
Biological Process GO Annotation Evidence References Source
acts upstream of or within endothelial cell migration IMP
IMP: Inferred from mutant phenotype
24403062 GOA
involved in positive regulation of establishment of protein localization IMP
IMP: Inferred from mutant phenotype
23178297 GOA
involved in positive regulation of non-canonical NF-kappaB signal transduction IDA
IDA: Inferred from direct assay
23178297 GOA
involved in regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
23178297 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IMP
IMP: Inferred from mutant phenotype
23178297 GOA
located in nucleus IMP
IMP: Inferred from mutant phenotype
23178297 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PTP4A3 Protein Structure

Y_phosphatase

Y_phosphatase: Protein-tyrosine phosphatase (42 - 147)

  • 0
  • 100
  • 173 a.a.
Protein Preferred Names Protein Names

protein tyrosine phosphatase type IVA 3

  • phosphatase of regenerating liver 3

Recombinant PTP4A3 Proteins

Cat. No. Product Name Accession Purity
HY-P701033 PTP4A3 Protein, Human (His) O75365-1 (M1-C170) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-135457 JMS-053 Inhibitor 98.0% Unkown
HY-183953 JMS-038 Inhibitor / Unkown
HY-RS11411 PTP4A3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19807 Ptp4a3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26303 Ptp4a3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta PTP4A3 VGNC VGNC:76596
Mus musculus PTP4A3 MGD MGI:1277098
Canis familiaris PTP4A3 VGNC VGNC:45163
Felis catus PTP4A3 VGNC VGNC:81706
Bos taurus PTP4A3 VGNC VGNC:33525
Rattus norvegicus PTP4A3 RGD RGD:1308687
Others PTP4A3 NCBI