FSTL1 - follistatin like 1 Gene

Also Known as FRP; FSL1; OCC1; OCC-1; tsc36; MIR198

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 11167

About FSTL1

Cytogenetic location: 3q13.33 Genomic coordinates (GRCh38): 3:120,392,293-120,450,992 (from NCBI)

This gene has 10 transcripts (splice variants), 233 orthologues and 6 paralogues. Broad expression in placenta (RPKM 238.4), gall bladder (RPKM 177.0) and 21 other tissues.

Summary

This gene encodes a protein with similarity to Follistatin, an activin-binding protein. It contains an FS module, a follistatin-like sequence containing 10 conserved cysteine residues. This gene product is thought to be an autoantigen associated with rheumatoid arthritis. [provided by RefSeq, Jul 2008]

FSTL1 Products (1)

mRNA Protein Name
NM_007085.5 NP_009016.1 follistatin-related protein 1 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
19060904 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FSTL1 Protein Structure

FOLN

FOLN: Follistatin/Osteonectin-like EGF domain (31 - 52)

Kazal_2

Kazal_2: Kazal-type serine protease inhibitor domain (58 - 98)

  • 0
  • 100
  • 200
  • 308 a.a.
Protein Preferred Names Protein Names

follistatin-related protein 1

  • follistatin-like protein 1

FSTL1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
FSTL1 Q12841 BMP2 Homo sapiens P12643
SPR
20860622
Intra
FSTL1 Q12841 BMP2 Homo sapiens P12643
Competition Binding
20860622
Intra
FSTL1 Q12841 DIP2A Homo sapiens Q14689
SPR
20860622
Intra
FSTL1 Q12841 DIP2A Homo sapiens Q14689
Competition Binding
20860622
Intra
FSTL1 Q12841 DIP2A Homo sapiens Q14689
Anti Tag CoIP
20860622
Intra
FSTL1 Q12841 SGTA Homo sapiens O43765
Y2H Array
32296183
Intra
FSTL1 Q12841 CD14 Homo sapiens P08571
Y2H
20860622
Intra
FSTL1 Q12841 SPRED1 Homo sapiens Q7Z699
Y2H Pooling
32814053
Intra
FSTL1 Q12841 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32814053
Intra
FSTL1 Q12841 SPRED1 Homo sapiens Q7Z699
Y2H Array
32814053
Intra
FSTL1 Q12841 APPBP2 Homo sapiens Q92624
Validated Y2H
32296183
Intra
FSTL1 Q12841 APPBP2 Homo sapiens Q92624
Y2H Array
32296183
Intra
FSTL1 Q12841 APPBP2 Homo sapiens Q92624
Y2H Prey Pooling
25416956
Intra
FSTL1 Q12841 APPBP2 Homo sapiens Q92624
Validated Y2H
25416956
Intra
FSTL1 Q12841 APPBP2 Homo sapiens Q92624
Y2H Prey Pooling
32296183
Intra
FSTL1 Q12841 INHBA Homo sapiens A4D1W7
Competition Binding
20860622
Intra
FSTL1 Q12841 INHBA Homo sapiens A4D1W7
SPR
20860622
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant FSTL1 Proteins

Cat. No. Product Name Accession Purity
HY-P70412 Follistatin-like 1/FSTL1 Protein, Human (HEK293, His) Q12841 (E21-I308) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P72640 Follistatin-like 1/FSTL1 Protein, Human (His) Q12841 (E21-I308) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Rheumatoid Arthritis

  • RA

  • Arthritis, Rheumatoid

  • Rheumatoid Arthritis, Susceptibility To

  • Arthritis Or Polyarthritis, Rheumatic

  • Atrophic Arthritis

  • Rheumatism Arthritis

  • Rheumatoid Polyarthritis
Arthritis

  • Inflammatory Joint Disease

  • Inflammatory Disorder Of Joint
Coronary Aneurysm

  • Aneurysm Of Coronary Vessels

  • Aneurysmal Lesion Of Coronary Artery

  • Arteriovenous Aneurysm Of Coronary Vessels
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05128 FSTL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16900 Fstl1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23342 Fstl1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus FSTL1 RGD RGD:68955
Bos taurus FSTL1 VGNC VGNC:29135
Macaca mulatta FSTL1 VGNC VGNC:72824
Canis familiaris FSTL1 VGNC VGNC:49898
Mus musculus FSTL1 MGD MGI:102793
Felis catus FSTL1 VGNC VGNC:62380
Others FSTL1 NCBI