Hadh - hydroxyacyl-CoA dehydrogenase Gene

Also Known as Hadhsc

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 113965

Summary

Enables 3-hydroxyacyl-CoA dehydrogenase activity. Involved in several processes, including fatty acid beta-oxidation; negative regulation of Insulin secretion; and response to activity. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be active in mitochondrion. Biomarker of myocardial infarction and obesity. Human ortholog(s) of this gene implicated in familial hyperinsulinemic hypoglycemia 4. Orthologous to human HADH (hydroxyacyl-CoA dehydrogenase). [provided by Alliance of Genome Resources, Apr 2022]

Hadh Products (1)

mRNA Protein Name
NM_057186.2 NP_476534.1 hydroxyacyl-coenzyme A dehydrogenase, mitochondrial precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables 3-hydroxyacyl-CoA dehydrogenase activity IMP
IMP: Inferred from mutant phenotype
17491019 RGD
Biological Process GO Annotation Evidence References Source
involved in fatty acid beta-oxidation IMP
IMP: Inferred from mutant phenotype
17491019 RGD
involved in negative regulation of insulin secretion IMP
IMP: Inferred from mutant phenotype
17491019 RGD
involved in response to activity IDA
IDA: Inferred from direct assay
8231758 RGD
involved in response to hormone IEP
IEP: Inferred from expression pattern
18191600 RGD
involved in response to insulin IEP
IEP: Inferred from expression pattern
7050060 RGD
involved in response to xenobiotic stimulus IDA
IDA: Inferred from direct assay
12176671 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

hydroxyacyl-coenzyme A dehydrogenase, mitochondrial

  • HCDH

  • L-3-hydroxyacyl-Coenzyme A dehydrogenase, short chain

  • hydroxylacyl-Coenzyme A dehydrogenase, short chain

  • medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase

  • short-chain 3-hydroxyacyl-CoA dehydrogenase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-178918 XZA-1 99.59% Unkown
HY-E70239 2-Methylbutyryl-CoA / Unkown
HY-RS05989 HADH Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05990 HADHA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17745 Hadh Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24211 Hadh Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hadh NCBI NCBI:3033