MAPK7 - mitogen-activated protein kinase 7 Gene

Also Known as Bmk1; Erk5; Prkm7

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 114509

About MAPK7

Primary_assembly 10: 46,170,167-46,176,267 reverse strand.mRatBN7.2:CM026983.1

This gene has 2 transcripts (splice variants), 193 orthologues, 21 paralogues and is associated with 8 phenotypes. Biased expression in Lung (RPKM 3.3), Testes (RPKM 29.4) and 9 other tissues.

Summary

Enables ATP binding activity and MAP kinase activity. Involved in ERK5 cascade and protein autophosphorylation. Located in nucleus. Orthologous to human MAPK7 (mitogen-activated protein kinase 7). [provided by Alliance of Genome Resources, Apr 2022]

MAPK7 Products (1)

mRNA Protein Name
NM_001191547.1 NP_001178476.1 mitogen-activated protein kinase 7

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables ATP binding IDA
IDA: Inferred from direct assay
8663194 RGD
enables MAP kinase activity IDA
IDA: Inferred from direct assay
8663194 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
19103177 RGD
Biological Process GO Annotation Evidence References Source
involved in ERK5 cascade IMP
IMP: Inferred from mutant phenotype
11782488 RGD
involved in MAPK cascade IMP
IMP: Inferred from mutant phenotype
11782488 RGD
involved in negative regulation of smooth muscle cell apoptotic process IMP
IMP: Inferred from mutant phenotype
20724525 RGD
involved in protein autophosphorylation IDA
IDA: Inferred from direct assay
11782488 RGD
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
8663194 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAPK7 Protein Structure

STKc_ERK5

STKc_ERK5: cd07855 (48 - 383)

  • 0
  • 200
  • 400
  • 600
  • 812 a.a.
Protein Preferred Names Protein Names

mitogen-activated protein kinase 7

  • BMK-1

  • BMK1 kinase

  • ERK-5

  • MAP kinase 7

  • MAPK 7

  • big MAP kinase 1

  • extracellular signal-regulated kinase 5

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-148065 FMF-06-098-1 Inhibitor 98.77% Unkown
HY-148061 DB1113 99.86% Unkown
HY-148063 DB0614 96.07% Unkown
HY-149412 MHJ-627 Inhibitor / Unkown
HY-RS08118 MAPK7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08119 Mapk7 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08120 MAPK7 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens MAPK7 NCBI NCBI:5598