Casp4 - caspase 4 Gene

Also Known as Casp11

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 114555

About Casp4

Primary_assembly 8: 2,598,876-2,635,092 forward strand.mRatBN7.2:CM026981.1

This gene has 1 transcript (splice variant), 252 orthologues, 12 paralogues and is associated with 5 phenotypes. Biased expression in Spleen (RPKM 162.6), Thymus (RPKM 161.5) and 9 other tissues.

Summary

Enables scaffold protein binding activity. Predicted to be involved in several processes, including cellular response to amyloid-beta; positive regulation of tumor necrosis factor-mediated signaling pathway; and protein autoprocessing. Predicted to act upstream of or within ectopic germ cell programmed cell death; positive regulation of interleukin-1 beta production; and Pyroptosis. Located in neuron projection and neuronal cell body. Part of protein-containing complex. Orthologous to human CASP4 (Caspase 4). [provided by Alliance of Genome Resources, Apr 2022]

Casp4 Products (1)

mRNA Protein Name
NM_053736.2 NP_446188.2 caspase 4

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
19416975 RGD
enables scaffold protein binding IPI
IPI: Inferred from physical interaction
19416975 RGD
Cellular Component GO Annotation Evidence References Source
located in neuronal cell body IDA
IDA: Inferred from direct assay
19401709 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
19416975 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Casp4 Protein Structure

CARD_CASP1-like

CARD_CASP1-like: cd08325 (4 - 84)

CASc

CASc: smart00115 (121 - 370)

  • 0
  • 100
  • 200
  • 300
  • 373 a.a.
Protein Preferred Names Protein Names

caspase 4

  • caspase 11

  • caspase 4, apoptosis-related cysteine peptidase

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-18678A Bremelanotide Acetate Agonist 99.97% Unkown

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01955 CASP4 Human Pre-designed siRNA Set A / Unkown
HY-RS01956 Casp4 Mouse Pre-designed siRNA Set A / Unkown
HY-RS01957 Casp4 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Casp4 NCBI NCBI:837