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CASP4 - caspase 4 Gene

Also Known as TX; Mih1; ICH-2; Mih1/TX; ICEREL-II; ICE(rel)II

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 837

About CASP4

Cytogenetic location: 11q22.3 Genomic coordinates (GRCh38): 11:104,942,866-104,968,574 (from NCBI)

This gene has 13 transcripts (splice variants), 421 orthologues and 16 paralogues. Ubiquitous expression in appendix (RPKM 42.7), lymph node (RPKM 37.1) and 24 other tissues.

Summary

This gene encodes a protein that is a member of the cysteine-aspartic acid protease (Caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell Apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This Caspase is able to cleave and activate its own precursor protein, as well as Caspase 1 precursor. When overexpressed, this gene induces cell Apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

CASP4 Products (4)

mRNA	Protein	Name
XM_011543019.2	XP_011541321.1	caspase-4 isoform X1
NM_001225.4	NP_001216.1	caspase-4 isoform alpha precursor
NM_033306.3	NP_150649.1	caspase-4 isoform gamma precursor
NM_033307.2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables CARD domain binding	IPI IPI: Inferred from physical interaction	16920334	GOA
enables cysteine-type endopeptidase activity	IDA IDA: Inferred from direct assay	16920334	GOA
enables lipid binding	IDA IDA: Inferred from direct assay	25119034	GOA
enables lipopolysaccharide binding	IDA IDA: Inferred from direct assay	25119034	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	29077095	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to amyloid-beta	IMP IMP: Inferred from mutant phenotype	15123740	GOA
involved in defense response to Gram-positive bacterium	IDA IDA: Inferred from direct assay	33377178	GOA
involved in defense response to bacterium	IDA IDA: Inferred from direct assay	25119034	GOA
involved in intrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	15123740	GOA
involved in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IMP IMP: Inferred from mutant phenotype	15123740	GOA
involved in non-canonical inflammasome complex assembly	IDA IDA: Inferred from direct assay	25119034	GOA
involved in positive regulation of inflammatory response	IDA IDA: Inferred from direct assay	33377178	GOA
involved in positive regulation of interleukin-18-mediated signaling pathway	IDA IDA: Inferred from direct assay	33377178	GOA
involved in positive regulation of tumor necrosis factor-mediated signaling pathway	IDA IDA: Inferred from direct assay	16920334	GOA
involved in protein autoprocessing	IDA IDA: Inferred from direct assay	32109412	GOA
involved in protein maturation	IDA IDA: Inferred from direct assay	25119034	GOA
involved in pyroptotic inflammatory response	IDA IDA: Inferred from direct assay	31268602	GOA
involved in regulation of inflammatory response	IDA IDA: Inferred from direct assay	32109412	GOA

Cellular Component GO Annotation	Evidence	References	Source
is active in cytosol	IDA IDA: Inferred from direct assay	23661706	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	15123740	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	15123740	GOA
part of non-canonical inflammasome complex	IDA IDA: Inferred from direct assay	25119034	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	16920334	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CASP4 Protein Structure

CARD

Peptidase_C14

0
100
200
300
377 a.a.

Protein Preferred Names	Protein Names
caspase-4	CASP-4 ICE and Ced-3 homolog 2 ICE(rel)-II apoptotic cysteine protease Mih1/TX caspase 4, apoptosis-related cysteine peptidase caspase 4, apoptosis-related cysteine protease protease ICH-2 protease TX

CASP4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CASP4	P49662	ARHGAP44	Homo sapiens	Q17R89	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

CASP4 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P811016	Caspase 4 Antibody	WB, IHC-P, ICC/IF	Human, Mouse, Rat
HY-P81251	CASP4 Antibody	WB, ELISA	Human, Rat

Related Diseases

Diseases	Alias
Cowpox	Yaba
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers
Cystinosis	Cystine Storage Disease Cystine Diathesis Cystine Disease Cystinoses Protein Defect Of Cystin Transport Cystin Transport, Protein Defect Of Nephropathic Cystinosis Protein Defect Of Cystine Transport
Neuroblastoma	Nb Neuroblastoma, Susceptibility To Neuroblastomas Central Neuroblastoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-18678A	Bremelanotide Acetate	Agonist	99.97%	Unkown

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Purity	Rare Diseases
HY-RS01955	CASP4 Human Pre-designed siRNA Set A	/	Unkown
HY-RS01956	Casp4 Mouse Pre-designed siRNA Set A	/	Unkown
HY-RS01957	Casp4 Rat Pre-designed siRNA Set A	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CASP4	MGD	MGI:107700
Macaca mulatta	CASP4	VGNC	VGNC:70543
Rattus norvegicus	CASP4	RGD	RGD:621757
Others	CASP4	NCBI