Acvr2b - activin receptor IIB Gene
Also Known as ActRIIB; AI047905; 4930516B21Rik
Species: Mus musculus
About Acvr2b
This gene has 6 transcripts (splice variants), 259 orthologues, 11 paralogues and is associated with 37 phenotypes. Broad expression in CNS E11.5 (RPKM 12.1), whole brain E14.5 (RPKM 7.8) and 2 other tissues.
Summary
Enables activin binding activity; growth factor binding activity; and protein kinase activity. Involved in blood vessel remodeling; negative regulation of cold-induced thermogenesis; and vasculature development. Acts upstream of or within several processes, including animal organ development; embryonic morphogenesis; and Insulin secretion. Predicted to be located in cytoplasm. Predicted to be part of activin receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; egg cylinder; genitourinary system; nervous system; and sensory organ. Used to study right atrial isomerism and visceral heterotaxy. Human ortholog(s) of this gene implicated in visceral heterotaxy. Orthologous to human ACVR2B (Activin A receptor type 2B). [provided by Alliance of Genome Resources, Apr 2022]
Acvr2b Products (2)
| mRNA | Protein | Name |
|---|---|---|
| NM_007397.3 | NP_031423.1 | activin receptor type-2B precursor |
| NM_001313757.1 | NP_001300686.1 | activin receptor type-2B isoform 2 precursor |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables activin binding |
IDA
IDA: Inferred from direct assay
|
15304227 | MGI |
| enables activin binding |
IPI
IPI: Inferred from physical interaction
|
1310075 | MGI |
| enables growth factor binding |
IMP
IMP: Inferred from mutant phenotype
|
12414726 | MGI |
| enables growth factor binding |
IPI
IPI: Inferred from physical interaction
|
11459935 | MGI |
| enables kinase activator activity |
IDA
IDA: Inferred from direct assay
|
16806156 | MGI |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
11882656 | MGI |
| enables protein serine/threonine kinase activity |
IDA
IDA: Inferred from direct assay
|
1326537 | MGI |
| enables protein serine/threonine/tyrosine kinase activity |
IDA
IDA: Inferred from direct assay
|
1326537 | MGI |
| NOT enables transforming growth factor beta binding |
IDA
IDA: Inferred from direct assay
|
1326537 | MGI |
Acvr2b Protein Structure
Activin_recp: pfam01064 (40 - 109)
STKc_ACVR2b: cd14140 (193 - 483)
- 0
- 100
- 200
- 300
- 400
- 512 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
activin receptor type-2B |
|
Acvr2b Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Cross
|
Acvr2b | P27040 | ACVR1B | Homo sapiens | P36896 | 14966532 |
Recombinant Acvr2b Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P75535 | ACVR2B Protein, Mouse (HEK293, His-hFc) | P27040-1 (S19-T134) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P75536 | ACVR2B Protein, Mouse (HEK293, His) | P27040-1 (S19-T134) | ≥ 90%, as determined by reducing SDS-PAGE. |
Related Agents
- Clinical Phase
- Pre-clinical Phase
Clinical Phase
| Cat. No. | Product Name |
Effect
|
Purity |
Phase
|
|---|---|---|---|---|
| HY-P99355 | Bimagrumab | Inhibitor | 99.31% | Phase 3 |
Pre-clinical Phase
| Cat. No. | Product Name |
Effect
|
Purity |
Rare Diseases
|
|---|---|---|---|---|
| HY-185430 | HM-279 | Inhibitor | / | Unkown |
| HY-W1142089 | ActRIIB-IN-2 | Inhibitor | / | Unkown |
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