2. Gene
  3. Acvr2b - activin receptor IIB Gene

Acvr2b - activin receptor IIB Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as ActRIIB; AI047905; 4930516B21Rik

Gene ID: 11481 | Gene type: protein coding

About Acvr2b

Chromosome 9: 119,231,184-119,264,061 forward strand.GRCm39:CM001002.3

This gene has 6 transcripts (splice variants), 259 orthologues, 11 paralogues and is associated with 37 phenotypes. Broad expression in CNS E11.5 (RPKM 12.1), whole brain E14.5 (RPKM 7.8) and 2 other tissues.

Summary

Enables activin binding activity; growth factor binding activity; and protein kinase activity. Involved in blood vessel remodeling; negative regulation of cold-induced thermogenesis; and vasculature development. Acts upstream of or within several processes, including animal organ development; embryonic morphogenesis; and Insulin secretion. Predicted to be located in cytoplasm. Predicted to be part of activin receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; egg cylinder; genitourinary system; nervous system; and sensory organ. Used to study right atrial isomerism and visceral heterotaxy. Human ortholog(s) of this gene implicated in visceral heterotaxy. Orthologous to human ACVR2B (Activin A receptor type 2B). [provided by Alliance of Genome Resources, Apr 2022]

Acvr2b Products(2)

mRNA Protein Name
NM_007397.3 NP_031423.1 activin receptor type-2B precursor
NM_001313757.1 NP_001300686.1 activin receptor type-2B isoform 2 precursor

Acvr2b Protein Structure

Activin_recp

Activin_recp: pfam01064 (40 - 109)

STKc_ACVR2b

STKc_ACVR2b: cd14140 (193 - 483)

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  • 512 a.a.
Protein Preferred Names Protein Names

activin receptor type-2B

activin receptor type IIB

Recombinant Acvr2b Proteins

Cat. No. Product Name Accession Purity
HY-P75535 ACVR2B Protein, Mouse (HEK293, His-hFc) P27040 (S19-T134) ≥95%
HY-P75536 ACVR2B Protein, Mouse (HEK293, His) P27040 (S19-T134) ≥95%

Related Agents

Clinical Phase
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99355 Bimagrumab Inhibitor 99.07% Phase 3

Orthologs Information

Species Symbol Source ID
Homo sapiens Acvr2b NCBI NCBI:93
Macaca fascicularis Acvr2b NCBI NCBI:102118668