ActRIIB-IN-2
ActRIIB-IN-2 is an ActRIIB inhibitor with an IC50 of 1.1 nM. ActRIIB-IN-2 can be used for the research of cancer cachexia.
For research use only. We do not sell to patients.
- CAS No.: 3039974-32-5
- Formula: C26H25N5
- Molecular Weight:407.51
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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ACVR2B 1.1 nM (IC50) |
ActRIIB-IN-2 (2.5 μM; 48 h) achieved a 90.87% reversal rate in myotube atrophy[1].
ActRIIB-IN-2 (Compound 3) potently inhibits ActRIIB in a cell-free biochemical assay with an IC50 of 1.1 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c mice (inoculated with 1 million C26 cells in each axilla to establish a colon cancer model)[1]
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Dosage:10 mg/kg
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Administration:i.p.; daily for 16 days
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Result:Alleviated weight loss to some extent.
Reduced tumor volume, but not significantly.
Improved appetite.
Significantly enhanced muscle grip strength.
Improved skeletal muscle atrophy to some extent.
Significantly alleviated the reduction in the cross-sectional area of the gastrocnemius muscle.
Chemical Information
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CAS No. 3039974-32-5
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Molecular Weight 407.51
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Formula C26H25N5
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SMILES
CN(CC1)CCN1C(C=C2)=CC=C2C3=CC4=C(NC=C4C5=CC6=C(NC=C6)C=C5)N=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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