2. TGF-beta/Smad
  3. TGF-β Receptor
  4. ActRIIB-IN-2

ActRIIB-IN-2 is an ActRIIB inhibitor with an IC50 of 1.1 nM. ActRIIB-IN-2 can be used for the research of cancer cachexia.

For research use only. We do not sell to patients.

ActRIIB-IN-2

ActRIIB-IN-2 Chemical Structure

CAS No. : 3039974-32-5

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ActRIIB-IN-2 Related Antibodies

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Description

ActRIIB-IN-2 is an ActRIIB inhibitor with an IC50 of 1.1 nM. ActRIIB-IN-2 can be used for the research of cancer cachexia[1].

IC50 & Target[1]

ACVR2B

1.1 nM (IC50)

In Vitro

ActRIIB-IN-2 (2.5 μM; 48 h) achieved a 90.87% reversal rate in myotube atrophy[1].
ActRIIB-IN-2 (Compound 3) potently inhibits ActRIIB in a cell-free biochemical assay with an IC50 of 1.1 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ActRIIB-IN-2 Related Antibodies
In Vivo

ActRIIB-IN-2 (10 mg/kg; daily for 16 days) alleviates weight loss, muscle atrophy, and muscle strength in BABL/c mice inoculated with CT26 cells without affecting tumor size, and slightly improves appetite[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c mice (inoculated with 1 million C26 cells in each axilla to establish a colon cancer model)[1]
Dosage: 10 mg/kg
Administration: i.p.; daily for 16 days
Result: Alleviated weight loss to some extent.
Reduced tumor volume, but not significantly.
Improved appetite.
Significantly enhanced muscle grip strength.
Improved skeletal muscle atrophy to some extent.
Significantly alleviated the reduction in the cross-sectional area of ​​the gastrocnemius muscle.
Molecular Weight

407.51

Formula

C26H25N5
CAS No.
SMILES

CN(CC1)CCN1C(C=C2)=CC=C2C3=CC4=C(NC=C4C5=CC6=C(NC=C6)C=C5)N=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ActRIIB-IN-2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ActRIIB-IN-23039974-32-5TGF-β ReceptorTransforming growth factor beta receptorsActRIIBcancer cachexiaInhibitorinhibitorinhibit

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