Adam9 - a disintegrin and metallopeptidase domain 9 (meltrin gamma) Gene

Also Known as MDC9; Mltng; mKIAA0021

Species: Mus musculus

Gene Type: protein coding
Gene ID: 11502

Summary

Enables SH3 domain binding activity; metalloendopeptidase activity; and protein kinase C binding activity. Involved in several processes, including cell adhesion mediated by integrin; membrane protein ectodomain proteolysis; and positive regulation of membrane protein ectodomain proteolysis. Located in several cellular components, including cell surface; extracellular space; and plasma membrane. Is intrinsic component of external side of plasma membrane. Is expressed in foregut-midgut junction. Used to study cone-rod dystrophy 9. Human ortholog(s) of this gene implicated in cone-rod dystrophy 9. Orthologous to human ADAM9 (ADAM metallopeptidase domain 9). [provided by Alliance of Genome Resources, Apr 2022]

Adam9 Products (2)

mRNA Protein Name
NM_001270996.1 NP_001257925.1 disintegrin and metalloproteinase domain-containing protein 9 isoform 1 precursor
NM_007404.2 NP_031430.2 disintegrin and metalloproteinase domain-containing protein 9 isoform 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables SH3 domain binding IDA
IDA: Inferred from direct assay
8647900 MGI
enables metalloendopeptidase activity IDA
IDA: Inferred from direct assay
22480688 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10531379 MGI
enables protein kinase C binding IPI
IPI: Inferred from physical interaction
9857183 MGI
Biological Process GO Annotation Evidence References Source
involved in cell adhesion mediated by integrin IDA
IDA: Inferred from direct assay
10825303 MGI
involved in cell migration IDA
IDA: Inferred from direct assay
10825303 MGI
involved in membrane protein ectodomain proteolysis IDA
IDA: Inferred from direct assay
19273593 MGI
involved in positive regulation of membrane protein ectodomain proteolysis IDA
IDA: Inferred from direct assay
9857183 MGI
involved in response to glucocorticoid IMP
IMP: Inferred from mutant phenotype
16311053 MGI
involved in transforming growth factor beta receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
11955914 MGI
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
8647900 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
15739225 MGI
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
9920899 MGI
located in extracellular space IMP
IMP: Inferred from mutant phenotype
9920899 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
15739225 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

disintegrin and metalloproteinase domain-containing protein 9

  • a disintegrin and metalloproteinase domain 9 (meltrin gamma)

  • metalloprotease/disintegrin/cysteine-rich protein 9

  • myeloma cell metalloproteinase

Recombinant Adam9 Proteins

Cat. No. Product Name Accession Purity
HY-P75531 ADAM9 Protein, Mouse (HEK293, His) Q61072 (G30-D697) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P990027 Izeltabart Inhibitor 98.62% Phase 2

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-139441 DM21 Inhibitor 99.34% Unkown
HY-P3722A Mca-PLAQAV-Dpa-RSSSR-NH2 TFA 99.54% Unkown
HY-124813 PDZ1i Inhibitor 99.29% Unkown
HY-P3722 Mca-PLAQAV-Dpa-RSSSR-NH2 Substrate 99.33% Unkown
HY-RS00289 ADAM9 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17598 Adam9 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24058 Adam9 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Adam9 NCBI NCBI:8754