2. Gene
  3. ATG4A - autophagy related 4A cysteine peptidase Gene

ATG4A - autophagy related 4A cysteine peptidase Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as APG4A; AUTL2; HsAPG4A

Gene ID: 115201 | Gene type: protein coding

About ATG4A

Cytogenetic location: Xq22.3 Genomic coordinates (GRCh38): X:108,088,829-108,154,671 (from NCBI)

This gene has 8 transcripts (splice variants), 162 orthologues and 3 paralogues. Ubiquitous expression in thyroid (RPKM 5.4), colon (RPKM 5.0) and 25 other tissues.

Summary

Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of Autophagy have been described in some malignant tumors, and a role for Autophagy in controlling the unregulated cell growth linked to Cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. [provided by RefSeq, Mar 2016]

ATG4A Products(7)

mRNA Protein Name
NM_001321287.2 NP_001308216.1 cysteine protease ATG4A isoform c
NM_001321288.2 NP_001308217.1 cysteine protease ATG4A isoform c
NM_001321289.2 NP_001308218.1 cysteine protease ATG4A isoform d
NM_001321290.2 NP_001308219.1 cysteine protease ATG4A isoform e
NM_052936.5 NP_443168.2 cysteine protease ATG4A isoform a
NM_178270.4 NP_840054.1 cysteine protease ATG4A isoform b
NM_178271.3 NP_840055.1 cysteine protease ATG4A isoform c

ATG4A Protein Structure

Peptidase_C54

Peptidase_C54: Peptidase family C54 (40 - 337)

  • 0
  • 100
  • 200
  • 300
  • 398 a.a.
Protein Preferred Names Protein Names

cysteine protease ATG4A

APG4 autophagy 4 homolog A

Recombinant ATG4A Proteins

Cat. No. Product Name Accession Purity
HY-P7618 ATG4A Protein, Human (His) Q8WYN0 (M1-V398) ≥95%

Related Diseases

Diseases Alias
Neurodegeneration With Brain Iron Accumulation

Nbia

Neurodegeneration With Brain Iron Accumulation Disorders

Neurodegeneration, With Brain Iron Accumulation
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01148 ATG4A Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus ATG4A RGD RGD:1596915
Bos taurus ATG4A VGNC VGNC:26257
Canis familiaris ATG4A VGNC VGNC:38223
Macaca mulatta ATG4A VGNC VGNC:70082
Mus musculus ATG4A MGD MGI:2147903
Felis catus ATG4A VGNC VGNC:60002
Others ATG4A NCBI