Aif1 - allograft inflammatory factor 1 Gene

Also Known as G1; Iba1; AIF-1; D17H6S50E

Species: Mus musculus

Gene Type: protein coding
Gene ID: 11629

Summary

Enables actin filament binding activity and calcium ion binding activity. Involved in several processes, including Rac protein signal transduction; actin filament organization; and ruffle assembly. Acts upstream of or within actin filament bundle assembly. Located in several cellular components, including actin filament; phagocytic cup; and ruffle membrane. Is expressed in adrenal cortex; central nervous system; embryo mesenchyme; and retina. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human AIF1 (allograft inflammatory factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Aif1 Products (5)

mRNA Protein Name
NM_001361501.2 NP_001348430.1 allograft inflammatory factor 1 isoform a
NM_001361502.2 NP_001348431.1 allograft inflammatory factor 1 isoform b
NM_001409899.1 NP_001396828.1 allograft inflammatory factor 1 isoform a
NM_001409902.1 NP_001396831.1 allograft inflammatory factor 1 isoform a
NM_019467.4 NP_062340.1 allograft inflammatory factor 1 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables actin filament binding IMP
IMP: Inferred from mutant phenotype
11500035 MGI
enables calcium ion binding IDA
IDA: Inferred from direct assay
17011575 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
14756805 MGI
Biological Process GO Annotation Evidence References Source
involved in Rac protein signal transduction IMP
IMP: Inferred from mutant phenotype
10934045 MGI
involved in actin crosslink formation IMP
IMP: Inferred from mutant phenotype
11500035 MGI
acts upstream of or within actin filament bundle assembly IDA
IDA: Inferred from direct assay
14756805 MGI
involved in parallel actin filament bundle assembly IDA
IDA: Inferred from direct assay
11500035 MGI
involved in phagocytosis, engulfment IMP
IMP: Inferred from mutant phenotype
10934045 MGI
involved in ruffle assembly IMP
IMP: Inferred from mutant phenotype
10934045 MGI
Cellular Component GO Annotation Evidence References Source
located in actin filament IDA
IDA: Inferred from direct assay
14756805 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
10934045 MGI
located in glial cell projection IDA
IDA: Inferred from direct assay
14756805 MGI
located in lamellipodium IDA
IDA: Inferred from direct assay
10934045 MGI
located in nucleus IDA
IDA: Inferred from direct assay
10934045 MGI
located in phagocytic cup IDA
IDA: Inferred from direct assay
10934045 MGI
located in ruffle IDA
IDA: Inferred from direct assay
14756805 MGI
located in ruffle membrane IDA
IDA: Inferred from direct assay
10934045 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

allograft inflammatory factor 1

  • ionized calcium binding adapter molecule 1

  • testis specific

Recombinant Aif1 Proteins

Cat. No. Product Name Accession Purity
HY-P72075 AIF1 Protein, Mouse (His) O70200 (S2-P147) ≥ 90%, as determined by reducing SDS-PAGE.

Aif1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P811555 AIF1 Antibody (YA10103) WB, IHC-P, IHC-F, ELISA, IF-Tissue Human, Mouse, Rat

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N4180 Pennogenin 3-O-beta-chacotrioside Modulator 99.91% Unkown
HY-RS00490 AIF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00491 AIF1L Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17578 Aif1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24038 Aif1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Aif1 NCBI NCBI:199