Kcnk4 - potassium two pore domain channel subfamily K member 4 Gene

Also Known as KT4.1; TRAAK

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 116489

Summary

Enables mechanosensitived Potassium Channel activity and temperature-gated cation channel activity. Involved in several processes, including cellular response to alkaline pH; cellular response to temperature stimulus; and potassium ion transmembrane transport. Is integral component of plasma membrane. Orthologous to human KCNK4 (potassium two pore domain channel subfamily K member 4). [provided by Alliance of Genome Resources, Apr 2022]

Kcnk4 Products (1)

mRNA Protein Name
NM_053804.3 NP_446256.3 potassium channel subfamily K member 4 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables mechanosensitive potassium channel activity IDA
IDA: Inferred from direct assay
15677687 RGD
enables potassium channel activity IDA
IDA: Inferred from direct assay
11374070 RGD
enables potassium ion leak channel activity IDA
IDA: Inferred from direct assay
31630908 RGD
enables temperature-gated cation channel activity IDA
IDA: Inferred from direct assay
15677687 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to alkaline pH IDA
IDA: Inferred from direct assay
15677687 RGD
involved in cellular response to fatty acid IDA
IDA: Inferred from direct assay
15677687 RGD
involved in cellular response to temperature stimulus IDA
IDA: Inferred from direct assay
15677687 RGD
involved in detection of mechanical stimulus involved in sensory perception of touch IMP
IMP: Inferred from mutant phenotype
31630908 RGD
involved in memory IEP
IEP: Inferred from expression pattern
14730890 RGD
involved in neuronal action potential IMP
IMP: Inferred from mutant phenotype
31630908 RGD
involved in potassium ion transmembrane transport IDA
IDA: Inferred from direct assay
15677687 RGD
Cellular Component GO Annotation Evidence References Source
located in node of Ranvier IDA
IDA: Inferred from direct assay
31630908 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
15677687 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

potassium channel subfamily K member 4

  • TWIK-related arachidonic acid-stimulated potassium channel protein

  • potassium channel, two pore domain subfamily K, member 4

  • potassium inwardly-rectifying channel, subfamily K, member 4

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-B1500 2,2,2-Trichloroethanol Agonist 99.53% Unkown
HY-RS07160 KCNK4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21613 Kcnk4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28131 Kcnk4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kcnk4 NCBI NCBI:50801