Nlgn1 - neuroligin 1 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 116647

Summary

Enables several functions, including cell adhesion molecule binding activity; identical protein binding activity; and neurexin family protein binding activity. Involved in several processes, including modulation of chemical synaptic transmission; positive regulation of cellular component organization; and synapse organization. Acts upstream of or within synapse organization. Located in several cellular components, including Golgi apparatus; dendrite; and filopodium tip. Is active in glutamatergic synapse. Is integral component of postsynaptic specialization membrane. Biomarker of status epilepticus. Orthologous to human NLGN1 (neuroligin 1). [provided by Alliance of Genome Resources, Apr 2022]

Nlgn1 Products (1)

mRNA Protein Name
NM_053868.2 NP_446320.1 neuroligin-1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cell adhesion molecule binding IPI
IPI: Inferred from physical interaction
15797875 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
19730411 RGD
enables neurexin family protein binding IPI
IPI: Inferred from physical interaction
14522992 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
19730411 RGD
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
18093522 RGD
enables signaling receptor activity IDA
IDA: Inferred from direct assay
15797875 RGD
Biological Process GO Annotation Evidence References Source
involved in AMPA glutamate receptor clustering IMP
IMP: Inferred from mutant phenotype
21940442 RGD
involved in NMDA glutamate receptor clustering IDA
IDA: Inferred from direct assay
19450252 RGD
involved in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IDA
IDA: Inferred from direct assay
9325340 RGD
involved in cellular response to calcium ion IDA
IDA: Inferred from direct assay
14522992 RGD
involved in cytoskeletal matrix organization at active zone IMP
IMP: Inferred from mutant phenotype
19628693 RGD
NOT involved in inhibitory postsynaptic potential IDA
IDA: Inferred from direct assay
17582332 RGD
involved in long-term synaptic potentiation IMP
IMP: Inferred from mutant phenotype
23083734 RGD
involved in modulation of chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
25428619 RGD
involved in neuron cell-cell adhesion IDA
IDA: Inferred from direct assay
15797875 RGD
involved in neuron projection arborization IGI
IGI: Inferred from genetic interaction
22750515 RGD
involved in neuron projection development IGI
IGI: Inferred from genetic interaction
22750515 RGD
involved in positive regulation of dendritic spine development IDA
IDA: Inferred from direct assay
17582332 RGD
involved in positive regulation of dendritic spine development IMP
IMP: Inferred from mutant phenotype
15681343 RGD
involved in positive regulation of excitatory postsynaptic potential IDA
IDA: Inferred from direct assay
17582332 RGD
involved in positive regulation of excitatory postsynaptic potential IMP
IMP: Inferred from mutant phenotype
19628693 RGD
involved in positive regulation of filopodium assembly IDA
IDA: Inferred from direct assay
12930820 RGD
involved in positive regulation of intracellular signal transduction IDA
IDA: Inferred from direct assay
17582332 RGD
involved in positive regulation of presynaptic active zone assembly IDA
IDA: Inferred from direct assay
15797875 RGD
involved in positive regulation of protein localization to synapse IMP
IMP: Inferred from mutant phenotype
15681343 RGD
involved in positive regulation of ruffle assembly IDA
IDA: Inferred from direct assay
12930820 RGD
involved in positive regulation of synapse assembly IDA
IDA: Inferred from direct assay
15797875 RGD
involved in positive regulation of synaptic transmission, GABAergic IDA
IDA: Inferred from direct assay
12930820 RGD
involved in positive regulation of synaptic transmission, glutamatergic IDA
IDA: Inferred from direct assay
19730411 RGD
involved in positive regulation of synaptic transmission, glutamatergic IMP
IMP: Inferred from mutant phenotype
19628693 RGD
involved in positive regulation of synaptic vesicle endocytosis IMP
IMP: Inferred from mutant phenotype
19628693 RGD
involved in positive regulation of synaptic vesicle exocytosis IMP
IMP: Inferred from mutant phenotype
19628693 RGD
involved in postsynaptic density protein 95 clustering IDA
IDA: Inferred from direct assay
19450252 RGD
involved in postsynaptic density protein 95 clustering IMP
IMP: Inferred from mutant phenotype
12930820 RGD
involved in presynaptic membrane assembly IDA
IDA: Inferred from direct assay
15797875 RGD
involved in protein targeting IDA
IDA: Inferred from direct assay
9278515 RGD
involved in regulation of AMPA receptor activity IDA
IDA: Inferred from direct assay
17582332 RGD
involved in regulation of NMDA receptor activity IDA
IDA: Inferred from direct assay
17582332 RGD
involved in regulation of NMDA receptor activity IMP
IMP: Inferred from mutant phenotype
19628693 RGD
involved in regulation of presynapse organization EXP
EXP: Inferred from Experiment
10892652 RGD
involved in regulation of presynapse organization IDA
IDA: Inferred from direct assay
10892652 RGD
involved in regulation of presynapse organization IMP
IMP: Inferred from mutant phenotype
10892652 RGD
involved in synapse assembly IDA
IDA: Inferred from direct assay
15797875 RGD
acts upstream of or within synapse organization IDA
IDA: Inferred from direct assay
15681343 RGD
involved in synaptic vesicle clustering IDA
IDA: Inferred from direct assay
20534458 RGD
involved in synaptic vesicle clustering IMP
IMP: Inferred from mutant phenotype
19628693 RGD
involved in synaptic vesicle transport IMP
IMP: Inferred from mutant phenotype
19628693 RGD
involved in terminal button organization IMP
IMP: Inferred from mutant phenotype
19628693 RGD
Cellular Component GO Annotation Evidence References Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
15519238 RGD
located in cell surface IDA
IDA: Inferred from direct assay
15797875 RGD
located in dendrite IDA
IDA: Inferred from direct assay
17582332 RGD
located in dendritic shaft IDA
IDA: Inferred from direct assay
22539981 RGD
located in dendritic spine IDA
IDA: Inferred from direct assay
15519238 RGD
located in filopodium tip IDA
IDA: Inferred from direct assay
19450252 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
9927700 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
15519238 RGD
is active in postsynaptic specialization membrane IDA
IDA: Inferred from direct assay
9927700 RGD
located in postsynaptic specialization membrane IDA
IDA: Inferred from direct assay
15519238 RGD
located in synapse IDA
IDA: Inferred from direct assay
9278515 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

neuroligin-1

  • neuroligin I

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09339 NLGN1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19024 Nlgn1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25513 Nlgn1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nlgn1 NCBI NCBI:22871