NLGN1 - neuroligin 1 Gene

Homo sapiens

Also known as NL1

Gene ID: 22871 | Gene type: protein coding

About NLGN1

Cytogenetic location: 3q26.31 Genomic coordinates (GRCh38): 3:173,395,952-174,294,372 (from NCBI)

This gene has 11 transcripts (splice variants), 264 orthologues, 13 paralogues and is associated with 1 phenotype. Biased expression in brain (RPKM 1.7), testis (RPKM 0.4) and 11 other tissues.

Summary

This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. [provided by RefSeq, Jul 2008]

NLGN1 Products(15)

mRNA	Protein	Name
NM_001365923.2	NP_001352852.1	neuroligin-1 isoform 1
NM_001365924.2	NP_001352853.1	neuroligin-1 isoform 2
NM_001365925.2	NP_001352854.1	neuroligin-1 isoform 2
NM_001365926.2	NP_001352855.1	neuroligin-1 isoform 2
NM_001365927.2	NP_001352856.1	neuroligin-1 isoform 1
NM_001365928.2	NP_001352857.1	neuroligin-1 isoform 2
NM_001365929.2	NP_001352858.1	neuroligin-1 isoform 3
NM_001365930.2	NP_001352859.1	neuroligin-1 isoform 3
NM_001365931.2	NP_001352860.1	neuroligin-1 isoform 3
NM_001365932.2	NP_001352861.1	neuroligin-1 isoform 3
NM_001365933.2	NP_001352862.1	neuroligin-1 isoform 3
NM_001365934.2	NP_001352863.1	neuroligin-1 isoform 4
NM_001365935.2	NP_001352864.1	neuroligin-1 isoform 4
NM_001365936.2	NP_001352865.1	neuroligin-1 isoform 4
NM_014932.5	NP_055747.1	neuroligin-1 isoform 3

NLGN1 Protein Structure

COesterase

0
200
400
600
823 a.a.

Protein Preferred Names

Protein Names

neuroligin-1

Recombinant NLGN1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71152	Neuroligin-1/NLGN1 Protein, Human (631a.a, HEK293, His)	Q8N2Q7-2 (Q46-L676)	≥95%
HY-P74705	NLGN1 Protein, Human (HEK293, C-His)	Q8N2Q7-2/NP_055747.1 (Q46-S677)	≥95%

Related Diseases

Diseases

Alias

Autism 20

Autism, Susceptibility To, 20	AUTS20
{Autism, Susceptibility To, 20}

Pervasive Developmental Disorder

Pervasive Development Disorder	Pervasive Developmental Disorders
Pervasive Child Development Disorders	Autistic Behavior
Autism Spectrum Disorders

Asperger Syndrome

Asperger Disorder

Asperger Syndrome, Susceptibility To

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Pitt-Hopkins-Like Syndrome 1

Cortical Dysplasia-Focal Epilepsy Syndrome	CDFES
PTHSL1	Cdfe Syndrome
Pitt-Hopkins Like Syndrome 1	Pitt-Hopkins-Like Syndrome-1
Cntnap2-Related Developmental And Epileptic Encephalopathy	Cntnap2-Related Dee
Mesh	D006985
Mesh	D008607

Gilles De La Tourette Syndrome

Tourette Syndrome	Tourette Disorder
GTS	Ts
Gilles De La Tourette'S Syndrome	Motor-Verbal Tic Disorder
Guinon'S Disease	Psychogenic Tics
Tourette'S Syndrome	Chronic Motor And Vocal Tic Disorder
Td	Tourette'S Disease
Combined Vocal And Multiple Motor Tic Disorder [De La Tourette]	Combined Vocal And Multiple Motor Tic Disorder
Tic De La Tourette

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder	ADHD
Attention Deficit Disorder	Attention Deficit-Hyperactivity Disorder, Susceptibility To
Attention Deficit Disorder With Hyperactivity	Hyperkinetic Disorder
Hyperactivity Of Childhood	Attention-Deficit/Hyperactivity Disorder
Add	Addh
Attention Deficit	Attention Deficit Disorder Of Childhood With Hyperactivity
Attention Deficit Disorder With Hyperactivity Syndrome	Hyperkinetic Syndrome
Attention-Deficit Hyperactivity Disorder	Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type
Disturbance Of Activity And Attention	Disorder Of Activity And Attention
Adhd - [Attention Deficit Hyperactivity Disorder]	Hyperkinetic Disorders
Disorder Of Activity And Attention With Hyperkinesia	Attention Deficit Syndrome With Hyperactivity

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09339	NLGN1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	NLGN1	VGNC	VGNC:97209
Felis catus	NLGN1	VGNC	VGNC:63821
Bos taurus	NLGN1	VGNC	VGNC:58395
Macaca mulatta	NLGN1	VGNC	VGNC:75174
Rattus norvegicus	NLGN1	RGD	RGD:621117
Mus musculus	NLGN1	MGD	MGI:2179435
Others	NLGN1	NCBI

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