NLGN1 - neuroligin 1 Gene

Also Known as NL1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 22871

About NLGN1

Cytogenetic location: 3q26.31 Genomic coordinates (GRCh38): 3:173,395,952-174,294,372 (from NCBI)

This gene has 11 transcripts (splice variants), 264 orthologues, 13 paralogues and is associated with 1 phenotype. Biased expression in brain (RPKM 1.7), testis (RPKM 0.4) and 11 other tissues.

Summary

This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. [provided by RefSeq, Jul 2008]

NLGN1 Products (15)

mRNA Protein Name
NM_001365923.2 NP_001352852.1 neuroligin-1 isoform 1
NM_001365924.2 NP_001352853.1 neuroligin-1 isoform 2
NM_001365925.2 NP_001352854.1 neuroligin-1 isoform 2
NM_001365926.2 NP_001352855.1 neuroligin-1 isoform 2
NM_001365927.2 NP_001352856.1 neuroligin-1 isoform 1
NM_001365928.2 NP_001352857.1 neuroligin-1 isoform 2
NM_001365929.2 NP_001352858.1 neuroligin-1 isoform 3
NM_001365930.2 NP_001352859.1 neuroligin-1 isoform 3
NM_001365931.2 NP_001352860.1 neuroligin-1 isoform 3
NM_001365932.2 NP_001352861.1 neuroligin-1 isoform 3
NM_001365933.2 NP_001352862.1 neuroligin-1 isoform 3
NM_001365934.2 NP_001352863.1 neuroligin-1 isoform 4
NM_001365935.2 NP_001352864.1 neuroligin-1 isoform 4
NM_001365936.2 NP_001352865.1 neuroligin-1 isoform 4
NM_014932.5 NP_055747.1 neuroligin-1 isoform 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables PDZ domain binding IDA
IDA: Inferred from direct assay
17474715 GOA
enables scaffold protein binding IDA
IDA: Inferred from direct assay
17474715 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of dendritic spine morphogenesis IGI
IGI: Inferred from genetic interaction
23143522 GOA
involved in nervous system development IMP
IMP: Inferred from mutant phenotype
28841651 GOA
involved in neuron projection development IDA
IDA: Inferred from direct assay
22750515 GOA
involved in positive regulation of dendritic spine development IGI
IGI: Inferred from genetic interaction
23143522 GOA
involved in positive regulation of excitatory postsynaptic potential IGI
IGI: Inferred from genetic interaction
23143522 GOA
acts upstream of or within positive regulation of synapse assembly IDA
IDA: Inferred from direct assay
24613359 GOA
involved in regulation of NMDA receptor activity IGI
IGI: Inferred from genetic interaction
23143522 GOA
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IMP
IMP: Inferred from mutant phenotype
28841651 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NLGN1 Protein Structure

COesterase

COesterase: Carboxylesterase family (32 - 606)

  • 0
  • 200
  • 400
  • 600
  • 823 a.a.
Protein Preferred Names Protein Names

neuroligin-1

Recombinant NLGN1 Proteins

Cat. No. Product Name Accession Purity
HY-P74705 NLGN1 Protein, Human (HEK293, C-His) Q8N2Q7-2/NP_055747.1 (Q46-S677) ≥ 95%, as determined by reducing SDS-PAGE.

NLGN1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P811046 Neuroligin 1 Antibody WB, IHC-P, ICC/IF Human, Mouse, Rat

Related Diseases

Diseases Alias
Autism 20

  • Autism, Susceptibility To, 20

  • AUTS20

  • {Autism, Susceptibility To, 20}
Pervasive Developmental Disorder

  • Pervasive Development Disorder

  • Pervasive Developmental Disorders

  • Pervasive Child Development Disorders

  • Autistic Behavior

  • Autism Spectrum Disorders
Asperger Syndrome

  • Asperger Disorder

  • Asperger Syndrome, Susceptibility To
Autism

  • Autistic Disorder

  • Autism Susceptibility 1

  • Childhood Autism

  • Autistic Disorder Of Childhood Onset

  • Infantile Autism

  • Kanner'S Syndrome

  • Autistic
Pitt-Hopkins-Like Syndrome 1

  • Cortical Dysplasia-Focal Epilepsy Syndrome

  • CDFES

  • PTHSL1

  • Cdfe Syndrome

  • Pitt-Hopkins Like Syndrome 1

  • Pitt-Hopkins-Like Syndrome-1

  • Cntnap2-Related Developmental And Epileptic Encephalopathy

  • Cntnap2-Related Dee

  • Mesh

  • D006985

  • Mesh

  • D008607
Gilles De La Tourette Syndrome

  • Tourette Syndrome

  • Tourette Disorder

  • GTS

  • Ts

  • Gilles De La Tourette'S Syndrome

  • Motor-Verbal Tic Disorder

  • Guinon'S Disease

  • Psychogenic Tics

  • Tourette'S Syndrome

  • Chronic Motor And Vocal Tic Disorder

  • Td

  • Tourette'S Disease

  • Combined Vocal And Multiple Motor Tic Disorder [De La Tourette]

  • Combined Vocal And Multiple Motor Tic Disorder

  • Tic De La Tourette
Schizophrenia

  • SCZD

  • Schizophrenia With Or Without An Affective Disorder

  • Schizophrenia 12

  • Schizophrenia, Susceptibility To

  • Schizophrenia-1

  • Dementia Praecox

  • Schizophrenia 1
Microcephaly

  • Microencephaly

  • Microcephalus

  • Microcephalic

  • Nanocephaly

  • Congenital Microcephaly

  • Brain Hypoplasia

  • Brain Nondevelopment

  • Cephalic Hypoplasia

  • Undeveloped Cerebrum

  • Undeveloped Brain

  • Micrencephalon

  • Micrencephaly
Attention Deficit-Hyperactivity Disorder

  • Attention Deficit Hyperactivity Disorder

  • ADHD

  • Attention Deficit Disorder

  • Attention Deficit-Hyperactivity Disorder, Susceptibility To

  • Attention Deficit Disorder With Hyperactivity

  • Hyperkinetic Disorder

  • Hyperactivity Of Childhood

  • Attention-Deficit/Hyperactivity Disorder

  • Add

  • Addh

  • Attention Deficit

  • Attention Deficit Disorder Of Childhood With Hyperactivity

  • Attention Deficit Disorder With Hyperactivity Syndrome

  • Hyperkinetic Syndrome

  • Attention-Deficit Hyperactivity Disorder

  • Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type

  • Disturbance Of Activity And Attention

  • Disorder Of Activity And Attention

  • Adhd - [Attention Deficit Hyperactivity Disorder]

  • Hyperkinetic Disorders

  • Disorder Of Activity And Attention With Hyperkinesia

  • Attention Deficit Syndrome With Hyperactivity
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09339 NLGN1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19024 Nlgn1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25513 Nlgn1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris NLGN1 VGNC VGNC:97209
Felis catus NLGN1 VGNC VGNC:63821
Bos taurus NLGN1 VGNC VGNC:58395
Macaca mulatta NLGN1 VGNC VGNC:75174
Rattus norvegicus NLGN1 RGD RGD:621117
Mus musculus NLGN1 MGD MGI:2179435
Others NLGN1 NCBI