Neuroligin 1 Antibody
(Synonyms: Kiaa1070, Nlgn1, Neuroligin-1)Neuroligin 1 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to Neuroligin 1.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P, ICC/IF
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|---|
| Dilution Ratio | 1:1000-2000 | 1:100-200 | 1:50-200 |
Product Details
Neuroligin 1 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to Neuroligin 1.
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Host Rabbit
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Clonality Polyclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 130 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 96 kDa
Synthetic peptide corresponding to the center region of human Neuroligin 1.
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Neuroligin 1 is a Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Required to maintain wakefulness quality and normal synchrony of cerebral cortex activity during wakefulness and sleep (By similarity). The protein is involved in nervous system development
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Subcellular Localization
Cell membrane; Postsynaptic density; Synaptic cleft; Synaptic cell membrane; Cell projection, dendrite; Synapse
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Expression
Tissue_Specificity: Expressed in the blood vessel walls (at protein level). Highly expressed in brain through prenatal stages, and at lower levels in pancreas islet beta cells. -
Isoforms & Post-Translational Modification
Neuroligin 1 has 2 isoforms, Q8N2Q7-3: amino acid length is 863, molecular weight is 96368 Da (predicted); Q8N2Q7-2: amino acid length is 823, molecular weight is 92000 Da (predicted).
N-glycosylated, contains high-mannose, hybrid, complex and sialylated N-glycans. N-glycosylation is essential for localization to synapses, dendrites, and the cell membrane, and enhances its availability for trans-synaptic adhesion. O-glycosylated. -
Subunit
Interacts with neurexins NRXN1, NRXN2 and NRXN3 (By similarity).
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SwissProt ID
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Synonyms
Kiaa1070, Nlgn1, Neuroligin-1
Documentation
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