Myt1l - myelin transcription factor 1-like Gene

Also Known as Nzf1; Nzf-1; Nztf1

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 116668

Summary

Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; retinoic acid-responsive element binding activity; and transition metal ion binding activity. Involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in chromosome. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability 39. Orthologous to human MYT1L (myelin transcription factor 1 like). [provided by Alliance of Genome Resources, Apr 2022]

Myt1l Products (1)

mRNA	Protein	Name
NM_053888.2	NP_446340.2	myelin transcription factor 1-like protein

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables DNA binding	IDA IDA: Inferred from direct assay	10606515	RGD
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	8631881	RGD
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	8631881	RGD
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IMP IMP: Inferred from mutant phenotype	8631881	RGD
enables cobalt ion binding	IMP IMP: Inferred from mutant phenotype	10606515	RGD
enables metal ion sequestering activity	EXP EXP: Inferred from Experiment	10606515	RGD
enables metal ion sequestering activity	IDA IDA: Inferred from direct assay	10606515	RGD
enables retinoic acid-responsive element binding	IDA IDA: Inferred from direct assay	8631881	RGD
enables retinoic acid-responsive element binding	IMP IMP: Inferred from mutant phenotype	10606515	RGD
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	8631881	RGD
enables zinc ion binding	IMP IMP: Inferred from mutant phenotype	10606515	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	8631881	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
myelin transcription factor 1-like protein	myT1-L neural zinc finger factor 1 neural zinc finger transcription factor 1

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08974	MYT1L Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21661	Myt1l Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28179	Myt1l Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Myt1l	NCBI	NCBI:23040