Alox15 - arachidonate 15-lipoxygenase Gene

Also Known as 12-LO; 15-LOX; L-12LO; Alox12l; 12/15-LO

Species: Mus musculus

Gene Type: protein coding
Gene ID: 11687

About Alox15

Chromosome 11: 70,234,978-70,242,857 reverse strand.GRCm39:CM001004.3

This gene has 2 transcripts (splice variants), 168 orthologues, 6 paralogues and is associated with 23 phenotypes. Broad expression in subcutaneous fat pad adult (RPKM 3.1), ovary adult (RPKM 2.5) and 24 other tissues.

Summary

Enables arachidonate 12(S)-lipoxygenase activity and arachidonate 15-lipoxygenase activity. Involved in several processes, including fatty acid metabolic process; phosphatidylethanolamine biosynthetic process; and positive regulation of actin filament polymerization. Acts upstream of or within bone mineralization. Located in cytosol and plasma membrane. Is expressed in several structures, including alimentary system; liver; nose; peritoneal fluid; and respiratory system. Orthologous to human ALOX15 (arachidonate 15-lipoxygenase). [provided by Alliance of Genome Resources, Apr 2022]

Alox15 Products (1)

mRNA Protein Name
NM_009660.3 NP_033790.3 polyunsaturated fatty acid lipoxygenase ALOX15

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables arachidonate 12(S)-lipoxygenase activity IDA
IDA: Inferred from direct assay
8188678 MGI
enables arachidonate 15-lipoxygenase activity IDA
IDA: Inferred from direct assay
8188678 MGI
Biological Process GO Annotation Evidence References Source
involved in apoptotic cell clearance IMP
IMP: Inferred from mutant phenotype
22503541 MGI
involved in arachidonate metabolic process IDA
IDA: Inferred from direct assay
8188678 MGI
involved in arachidonate metabolic process IMP
IMP: Inferred from mutant phenotype
8798642 MGI
acts upstream of or within bone mineralization IMP
IMP: Inferred from mutant phenotype
14716014 MGI
involved in lipoxin A4 biosynthetic process IMP
IMP: Inferred from mutant phenotype
15708862 MGI
involved in lipoxygenase pathway IDA
IDA: Inferred from direct assay
8188678 MGI
involved in lipoxygenase pathway IMP
IMP: Inferred from mutant phenotype
8798642 MGI
involved in negative regulation of adaptive immune response IMP
IMP: Inferred from mutant phenotype
22503541 MGI
acts upstream of or within ossification IMP
IMP: Inferred from mutant phenotype
14716014 MGI
involved in phosphatidylethanolamine biosynthetic process IMP
IMP: Inferred from mutant phenotype
22503541 MGI
involved in positive regulation of actin filament polymerization IMP
IMP: Inferred from mutant phenotype
11278875 MGI
involved in regulation of engulfment of apoptotic cell IMP
IMP: Inferred from mutant phenotype
11278875 MGI
involved in regulation of peroxisome proliferator activated receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
10432118 MGI
involved in response to endoplasmic reticulum stress IMP
IMP: Inferred from mutant phenotype
22215650 MGI
involved in wound healing IMP
IMP: Inferred from mutant phenotype
15708862 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
17426145 MGI
located in cytosol IDA
IDA: Inferred from direct assay
11278875 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
11278875 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Alox15 Protein Structure

PLAT_LOX

PLAT_LOX: cd01753 (1 - 111)

Lipoxygenase

Lipoxygenase: cl37981 (201 - 653)

  • 0
  • 200
  • 400
  • 600
  • 663 a.a.
Protein Preferred Names Protein Names

polyunsaturated fatty acid lipoxygenase ALOX15

  • 12-LOX

  • 12/15-lipoxygenase

  • arachidonate 12-lipoxygenase, leukocyte-type

  • arachidonate omega-6 lipoxygenase

  • hepoxilin A3 synthase Alox15

  • linoleate 13S-lipoxygenase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-143787 ALOX15-IN-1 Inhibitor 98.01% Unkown
HY-143791 ALOX15-IN-2 Inhibitor 99.88% Unkown
HY-113509B 15(R)-Lipoxin A4 98.3% Unkown
HY-RS00616 ALOX15 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00619 ALOX15B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00617 Alox15 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00618 Alox15 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27130 Alox15b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Alox15 NCBI NCBI:246