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Alox5 - arachidonate 5-lipoxygenase Gene

Also Known as 5LO; 5LX; 5-LO; 5-LOX; F730011J02

Species: Mus musculus

Gene Type: protein coding

Gene ID: 11689

About Alox5

Chromosome 6: 116,387,038-116,438,139 reverse strand.GRCm39:CM000999.3

This gene has 8 transcripts (splice variants), 221 orthologues, 6 paralogues and is associated with 17 phenotypes. Broad expression in lung adult (RPKM 3.4), heart adult (RPKM 2.7) and 22 other tissues.

Summary

Enables arachidonate 5-lipoxygenase activity. Involved in several processes, including leukocyte migration; negative regulation of angiogenesis; and regulation of cellular response to stress. Acts upstream of or within leukotriene biosynthetic process and leukotriene production involved in inflammatory response. Located in cytoplasm and nucleus. Is expressed in duodenum epithelium and small intestine epithelium. Human ortholog(s) of this gene implicated in artery disease (multiple); asthma (multiple); pancreatic cancer; and pulmonary tuberculosis. Orthologous to human ALOX5 (arachidonate 5-lipoxygenase). [provided by Alliance of Genome Resources, Apr 2022]

Alox5 Products (1)

mRNA	Protein	Name
NM_009662.2	NP_033792.1	polyunsaturated fatty acid 5-lipoxygenase

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables arachidonate 5-lipoxygenase activity	IDA IDA: Inferred from direct assay	23246375	MGI
enables arachidonate 5-lipoxygenase activity	IMP IMP: Inferred from mutant phenotype	31642348	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	19075240	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in dendritic cell migration	IMP IMP: Inferred from mutant phenotype	17392829	MGI
involved in glucose homeostasis	IMP IMP: Inferred from mutant phenotype	18421434	MGI
involved in humoral immune response	IMP IMP: Inferred from mutant phenotype	21224059	MGI
acts upstream of or within inflammatory response	IMP IMP: Inferred from mutant phenotype	11867678	MGI
involved in leukocyte migration involved in inflammatory response	IMP IMP: Inferred from mutant phenotype	28965882	MGI
involved in leukotriene A4 biosynthetic process	IMP IMP: Inferred from mutant phenotype	31642348	MGI
acts upstream of or within leukotriene biosynthetic process	IDA IDA: Inferred from direct assay	19075240	MGI
involved in leukotriene biosynthetic process	IMP IMP: Inferred from mutant phenotype	7809134	MGI
acts upstream of or within leukotriene metabolic process	IMP IMP: Inferred from mutant phenotype	11867678	MGI
acts upstream of or within leukotriene production involved in inflammatory response	IMP IMP: Inferred from mutant phenotype	9091580	MGI
involved in negative regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	21307302	MGI
involved in negative regulation of endothelial cell proliferation	IMP IMP: Inferred from mutant phenotype	21307302	MGI
involved in negative regulation of response to endoplasmic reticulum stress	IMP IMP: Inferred from mutant phenotype	28694473	MGI
involved in negative regulation of sprouting angiogenesis	IMP IMP: Inferred from mutant phenotype	21307302	MGI
involved in negative regulation of vascular wound healing	IMP IMP: Inferred from mutant phenotype	24226420	MGI
involved in negative regulation of wound healing	IMP IMP: Inferred from mutant phenotype	24226420	MGI
involved in positive regulation of bone mineralization	IMP IMP: Inferred from mutant phenotype	24906289	MGI
involved in positive regulation of leukocyte adhesion to arterial endothelial cell	IMP IMP: Inferred from mutant phenotype	23720274	MGI
involved in regulation of cellular response to oxidative stress	IMP IMP: Inferred from mutant phenotype	28694473	MGI
involved in regulation of cytokine production involved in inflammatory response	IMP IMP: Inferred from mutant phenotype	28965882	MGI
involved in regulation of fat cell differentiation	IMP IMP: Inferred from mutant phenotype	24906289	MGI
involved in regulation of inflammatory response	IMP IMP: Inferred from mutant phenotype	7809134	MGI
involved in regulation of inflammatory response to wounding	IMP IMP: Inferred from mutant phenotype	28965882	MGI
involved in regulation of insulin secretion	IMP IMP: Inferred from mutant phenotype	18421434	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	12140292	MGI
located in nucleus	IDA IDA: Inferred from direct assay	12140292	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Alox5 Protein Structure

PLAT_LOX

Lipoxygenase

0
200
400
600
674 a.a.

Protein Preferred Names	Protein Names
polyunsaturated fatty acid 5-lipoxygenase	5-lipoxygenase

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-150109A	Purinostat	Inhibitor	98.04%	Unkown
HY-RS00620	ALOX5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS00625	Alox5ap Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-175634	ALOX5 stabilizer-1		/	Unkown
HY-175634A	ALOX5 stabilizer-1 TFA		/	Unkown
HY-E71028	5-Lipoxygenase, Human		/	Unkown
HY-RS00621	Alox5 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS00622	Alox5 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS00623	ALOX5AP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS00624	Alox5ap Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Alox5	NCBI	NCBI:240