Apoa2 - apolipoprotein A-II Gene

Also Known as Alp-2; Hdl-1; ApoAII; Apoa-2; Apo-AII; ApoA-II

Species: Mus musculus

Gene Type: protein coding

Gene ID: 11807

Summary

This gene encodes a component of high density lipoproteins (HDL). Mice lacking the encoded protein have low HDL-cholesterol levels, smaller HDL particles, increased clearance of triglyceride-rich lipoproteins and Insulin hypersensitivity. Transgenic mice overexpressing the encoded protein have elevated levels of HDL-cholesterol and show increased susceptibility to atherosclerosis. Alternative splicing of this gene results in multiple variants. [provided by RefSeq, Mar 2015]

Apoa2 Products (4)

mRNA	Protein	Name
NM_001305549.1	NP_001292478.1	apolipoprotein A-II preproprotein
NM_001305550.1	NP_001292479.1	apolipoprotein A-II preproprotein
NM_001305585.1	NP_001292514.1	apolipoprotein A-II preproprotein
NM_013474.2	NP_038502.2	apolipoprotein A-II preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables high-density lipoprotein particle binding	IMP IMP: Inferred from mutant phenotype	14729860	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within cholesterol homeostasis	IDA IDA: Inferred from direct assay	8422330	MGI
acts upstream of or within cholesterol homeostasis	IGI IGI: Inferred from genetic interaction	10357838	MGI
acts upstream of or within cholesterol homeostasis	IMP IMP: Inferred from mutant phenotype	10357838	MGI
acts upstream of or within cholesterol metabolic process	IGI IGI: Inferred from genetic interaction	10357838	MGI
acts upstream of or within cholesterol metabolic process	IMP IMP: Inferred from mutant phenotype	8647961	MGI
acts upstream of or within lipid transport	IMP IMP: Inferred from mutant phenotype	14729860	MGI
acts upstream of or within lipoprotein metabolic process	IDA IDA: Inferred from direct assay	7837794	MGI
acts upstream of or within negative regulation of lipase activity	IMP IMP: Inferred from mutant phenotype	10357838	MGI
acts upstream of or within regulation of intestinal cholesterol absorption	IMP IMP: Inferred from mutant phenotype	8962133	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in extracellular space	IDA IDA: Inferred from direct assay	1596514	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
apolipoprotein A-II	apolipoprotein A2

Recombinant Apoa2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77562	Apolipoprotein A-II/APOA2 Protein, Mouse (HEK293, Fc)	P09813 (A19-K102)	≥ 95%, as determined by Bis-Tris PAGE.

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS19983	Apoa2 Mouse Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Apoa2	NCBI	NCBI:336