APOA2 - apolipoprotein A2 Gene

Also Known as apoAII; Apo-AII; ApoA-II

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 336

About APOA2

Cytogenetic location: 1q23.3 Genomic coordinates (GRCh38): 1:161,222,292-161,223,628 (from NCBI)

This gene has 10 transcripts (splice variants), 87 orthologues and is associated with 3 phenotypes. Restricted expression toward liver (RPKM 5129.5).

Summary

This gene encodes Apolipoprotein (apo-) A-II, which is the second most abundant protein of the high density lipoprotein particles. The protein is found in plasma as a monomer, homodimer, or heterodimer with Apolipoprotein D. Defects in this gene may result in Apolipoprotein A-II deficiency or hypercholesterolemia. [provided by RefSeq, Jul 2008]

APOA2 Products (1)

mRNA	Protein	Name
NM_001643.2	NP_001634.1	apolipoprotein A-II preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables apolipoprotein receptor binding	IPI IPI: Inferred from physical interaction	11162594	GOA
enables cholesterol binding	IDA IDA: Inferred from direct assay	218942	GOA
contributes to cholesterol transfer activity	IDA IDA: Inferred from direct assay	9651324	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	14967812	GOA
enables heat shock protein binding	IPI IPI: Inferred from physical interaction	11027668	GOA
enables high-density lipoprotein particle receptor binding	IPI IPI: Inferred from physical interaction	10764676	GOA
enables lipase inhibitor activity	IDA IDA: Inferred from direct assay	14967812	GOA
enables lipid binding	IDA IDA: Inferred from direct assay	14967812	GOA
enables lipid transporter activity	IDA IDA: Inferred from direct assay	1606170	GOA
enables phosphatidylcholine binding	IDA IDA: Inferred from direct assay	17264082	GOA
enables phosphatidylcholine-sterol O-acyltransferase activator activity	IDA IDA: Inferred from direct assay	14967812	GOA
enables phospholipid binding	IDA IDA: Inferred from direct assay	218942	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11991719	GOA
enables protein heterodimerization activity	IPI IPI: Inferred from physical interaction	7918467	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	17264082	GOA
enables receptor ligand activity	IDA IDA: Inferred from direct assay	27477018	GOA
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	27477018	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to lipoprotein particle stimulus	IDA IDA: Inferred from direct assay	27477018	GOA
involved in cholesterol efflux	IDA IDA: Inferred from direct assay	11162594	GOA
involved in cholesterol homeostasis	IDA IDA: Inferred from direct assay	14967812	GOA
involved in diacylglycerol catabolic process	IDA IDA: Inferred from direct assay	14967812	GOA
involved in high-density lipoprotein particle assembly	IDA IDA: Inferred from direct assay	218942	GOA
involved in high-density lipoprotein particle clearance	IDA IDA: Inferred from direct assay	10764676	GOA
involved in high-density lipoprotein particle remodeling	IDA IDA: Inferred from direct assay	8106353	GOA
involved in low-density lipoprotein particle remodeling	IDA IDA: Inferred from direct assay	8106353	GOA
involved in negative regulation of cholesterol import	IDA IDA: Inferred from direct assay	10764676	GOA
involved in negative regulation of cholesterol transport	IMP IMP: Inferred from mutant phenotype	8636092	GOA
involved in negative regulation of cholesterol transporter activity	IDA IDA: Inferred from direct assay	8106353	GOA
involved in negative regulation of cytokine production involved in immune response	IDA IDA: Inferred from direct assay	12458630	GOA
involved in negative regulation of lipase activity	IDA IDA: Inferred from direct assay	14967812	GOA
involved in negative regulation of lipid catabolic process	IDA IDA: Inferred from direct assay	14967812	GOA
involved in negative regulation of very-low-density lipoprotein particle remodeling	IDA IDA: Inferred from direct assay	14967812	GOA
involved in peptidyl-methionine modification	IDA IDA: Inferred from direct assay	12576517	GOA
involved in phosphatidylcholine biosynthetic process	IDA IDA: Inferred from direct assay	14967812	GOA
involved in phospholipid catabolic process	IDA IDA: Inferred from direct assay	14967812	GOA
involved in phospholipid efflux	IDA IDA: Inferred from direct assay	11162594	GOA
involved in positive regulation of CoA-transferase activity	IDA IDA: Inferred from direct assay	14967812	GOA
involved in positive regulation of interleukin-8 production	IDA IDA: Inferred from direct assay	11591715	GOA
involved in positive regulation of lipid catabolic process	IDA IDA: Inferred from direct assay	8640403	GOA
involved in positive regulation of phagocytosis	IDA IDA: Inferred from direct assay	20495215	GOA
involved in protein oxidation	IDA IDA: Inferred from direct assay	12576517	GOA
involved in protein stabilization	IDA IDA: Inferred from direct assay	20495215	GOA
involved in regulation of protein stability	IDA IDA: Inferred from direct assay	14967812	GOA
involved in response to glucose	IDA IDA: Inferred from direct assay	14988251	GOA
involved in reverse cholesterol transport	IDA IDA: Inferred from direct assay	14967812	GOA
involved in triglyceride-rich lipoprotein particle remodeling	IDA IDA: Inferred from direct assay	14967812	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of chylomicron	IDA IDA: Inferred from direct assay	8245722	GOA
is active in extracellular space	IDA IDA: Inferred from direct assay	24116940	GOA
part of high-density lipoprotein particle	IDA IDA: Inferred from direct assay	210174	GOA
part of spherical high-density lipoprotein particle	IDA IDA: Inferred from direct assay	16682745	GOA
part of very-low-density lipoprotein particle	IDA IDA: Inferred from direct assay	8245722	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

APOA2 Protein Structure

ApoA-II

0
100 a.a.

Protein Preferred Names	Protein Names
apolipoprotein A-II

APOA2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	APOA2	P02652	TMEM45A	Homo sapiens	Q9NWC5	Y2H Array	32296183
Intra	APOA2	P02652	TMEM45A	Homo sapiens	Q9NWC5	Y2H Prey Pooling	32296183
Intra	APOA2	P02652	TMEM45A	Homo sapiens	Q9NWC5	Validated Y2H	32296183
Intra	APOA2	P02652	STOM	Homo sapiens	P27105	Y2H Prey Pooling	32296183
Intra	APOA2	P02652	STOM	Homo sapiens	P27105	Validated Y2H	32296183
Intra	APOA2	P02652	STOM	Homo sapiens	P27105	Y2H Array	32296183
Intra	APOA2	P02652	AQP6	Homo sapiens	Q13520	Validated Y2H	32296183
Intra	APOA2	P02652	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
Intra	APOA2	P02652	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
Intra	APOA2	P02652	MUC1	Homo sapiens	P15941-11	Y2H Array	32296183
Intra	APOA2	P02652	MUC1	Homo sapiens	P15941-11	Y2H Prey Pooling	32296183
Intra	APOA2	P02652	MUC1	Homo sapiens	P15941-11	Validated Y2H	32296183
Intra	APOA2	P02652	SSMEM1	Homo sapiens	Q8WWF3	Y2H Prey Pooling	32296183
Intra	APOA2	P02652	SSMEM1	Homo sapiens	Q8WWF3	Validated Y2H	32296183
Intra	APOA2	P02652	SSMEM1	Homo sapiens	Q8WWF3	Y2H Array	32296183
Intra	APOA2	P02652	GJA8	Homo sapiens	P48165	Y2H Prey Pooling	32296183
Intra	APOA2	P02652	GJA8	Homo sapiens	P48165	Validated Y2H	32296183
Intra	APOA2	P02652	GJA8	Homo sapiens	P48165	Y2H Array	32296183
Intra	APOA2	P02652	HSD17B13	Homo sapiens	Q7Z5P4	Y2H Prey Pooling	32296183
Intra	APOA2	P02652	HSD17B13	Homo sapiens	Q7Z5P4	Validated Y2H	32296183
Intra	APOA2	P02652	HSD17B13	Homo sapiens	Q7Z5P4	Y2H Array	32296183
Intra	APOA2	P02652	GET1	Homo sapiens	O00258	Y2H Array	32296183
Intra	APOA2	P02652	GET1	Homo sapiens	O00258	Y2H Prey Pooling	32296183
Intra	APOA2	P02652	CYBC1	Homo sapiens	Q9BQA9	Y2H Prey Pooling	32296183
Intra	APOA2	P02652	CYBC1	Homo sapiens	Q9BQA9	Y2H Array	32296183
Intra	APOA2	P02652	CYBC1	Homo sapiens	Q9BQA9	Validated Y2H	32296183
Intra	APOA2	P02652	SLC7A1	Homo sapiens	P30825	Y2H Array	32296183
Intra	APOA2	P02652	SLC7A1	Homo sapiens	P30825	Y2H Prey Pooling	32296183
Intra	APOA2	P02652	SLC7A1	Homo sapiens	P30825	Validated Y2H	32296183
Intra	APOA2	P02652	PANX1	Homo sapiens	Q96RD7	Y2H Array	32296183
Intra	APOA2	P02652	PANX1	Homo sapiens	Q96RD7	Y2H Prey Pooling	32296183
Intra	APOA2	P02652	PANX1	Homo sapiens	Q96RD7	Validated Y2H	32296183
Intra	APOA2	P02652	PDZK1IP1	Homo sapiens	Q13113	Y2H Prey Pooling	32296183
Intra	APOA2	P02652	PDZK1IP1	Homo sapiens	Q13113	Validated Y2H	32296183
Intra	APOA2	P02652	PDZK1IP1	Homo sapiens	Q13113	Y2H Array	32296183
Intra	APOA2	P02652	CATSPER1	Homo sapiens	Q8NEC5	Validated Y2H	32296183
Intra	APOA2	P02652	CATSPER1	Homo sapiens	Q8NEC5	Y2H Array	25416956
Intra	APOA2	P02652	CATSPER1	Homo sapiens	Q8NEC5	Y2H Array	32296183
Intra	APOA2	P02652	CATSPER1	Homo sapiens	Q8NEC5	Validated Y2H	25416956
Intra	APOA2	P02652	CATSPER1	Homo sapiens	Q8NEC5	Y2H Prey Pooling	32296183
Intra	APOA2	P02652	CIAO2A	Homo sapiens	Q9H5X1	Validated Y2H	32296183
Intra	APOA2	P02652	CIAO2A	Homo sapiens	Q9H5X1	Y2H Array	32296183
Intra	APOA2	P02652	CIAO2A	Homo sapiens	Q9H5X1	Y2H Prey Pooling	32296183
Intra	APOA2	P02652	KIR2DL3	Homo sapiens	P43628	Y2H Array	32296183
Intra	APOA2	P02652	KIR2DL3	Homo sapiens	P43628	Y2H Prey Pooling	32296183
Intra	APOA2	P02652	KIR2DL3	Homo sapiens	P43628	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant APOA2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7527	Apolipoprotein A-II/APOA2 Protein, Human (Truncated, HEK293, His)	P02652 (Q24-Q100)	≥ 95%, as determined by reducing SDS-PAGE.

APOA2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81714	ApoA-II Antibody (YA1459)	WB, ICC/IF, FC	Human, Rat

Related Diseases

Diseases	Alias
Hypercholesterolemia, Familial, 1	Hypercholesterolemia FHCL1 Fhc Fh Hyperlipoproteinemia, Type Ii Hyperlipoproteinemia, Type Iia Hyper-Low-Density-Lipoproteinemia Hypercholesterolemic Xanthomatosis, Familial Ldl Receptor Disorder Hypercholesterolemia, Susceptibility To Hypercholesterolemia, Familial, Modifier Of Hypercholesterolemia, Familial, Due To Ldlr Defect, Modifier Of Ldl Cholesterol Level Qtl2 Hyperlipoproteinemia Type Ii Hypercholesterolemia, Familial, Type 1 High Cholesterol Increased Cholesterol Low-Density-Lipoid-Type Hyperlipoproteinemia Pure Hypercholesterolaemia Ldl - [Low Density Lipoprotein} Hyperlipoproteinemia Group A Hyperlipidaemia Pure Hypercholesterinaemia Cholesterolaemia Essential Cholesterolaemia Essential Hypercholesterolaemia Group A Hyperlipemia Increased Low Density Lipoprotein Low-Density-Lipoprotein-Type Low-Density-Lipoprotein-Type Hyperlipoproteinemia
Aapoaii Amyloidosis	Apolipoprotein A-Ii Amyloidosis Familial Amyloid Nephropathy Due To Apolipoprotein A-Ii Variant Familial Renal Amyloidosis Due To Apolipoprotein A-Ii Variant Hereditary Amyloid Nephropathy Due To Apolipoprotein A-Ii Variant Hereditary Renal Amyloidosis Due To Apolipoprotein A-Ii Variant
Familial Hypercholesterolemia	Hyperlipoproteinemia Type Iia Familial Hyperbetalipoproteinaemia Familial Hypercholesteremia Fredrickson Type Iia Hyperlipoproteinemia Fredrickson Type Iia Lipidaemia Hyperbetalipoproteinemia Type Ii Hyperlipidemia Familial Hypercholesterolæmia Familial Hypercholesterolaemia Fh Hypercholesterolemia Familial Hyperlipoproteinemia Type Ii Hypercholesterolemia, Familial
Lecithin:Cholesterol Acyltransferase Deficiency	Norum Disease Lcat Deficiency Familial Lcat Deficiency Fld Lecithin Acyltransferase Deficiency Complete Lcat Deficiency Lecithin Cholesterol Acyltransferase Deficiency Lecithin-Cholesterol Acyltransferase Deficiency Familial Lecithin-Cholesterol Acyltransferase Deficiency Norum'S Disease LCATD Deficiency, Lecithin:Cholesterol Acyltransferase
Hyperalphalipoproteinemia 1	Hyperalphalipoproteinemia HALP1 Cetp Deficiency Cholesterol-Ester Transfer Protein Deficiency Familial Hyperalphalipoproteinemia Cholesteryl Ester Transfer Protein Deficiency Cept Deficiency Cholesterol Ester Transfer Protein Deficiency
Fish-Eye Disease	FED Dyslipoproteinemic Corneal Dystrophy Alpha-Lcat Deficiency Lcata Deficiency Partial Lcat Deficiency Alpha-Lecithin:Cholesterol Acyltransferase Deficiency Alpha-Lecithin Cholesterol Acyltransferase Deficiency Disease, Fish-Eye Lecithin Acyltransferase Deficiency
Tangier Disease	Analphalipoproteinemia High Density Lipoprotein Deficiency, Tangier Type TGD High Density Lipoprotein Deficiency, Type 1 Hdldt1 Familial High Density Lipoprotein Deficiency A-Alphalipoprotein Neuropathy Alpha High Density Lipoprotein Deficiency Disease Cholesterol Thesaurismosis Familial High Density Lipoprotein Deficiency Disease Hdl Lipoprotein Deficiency Disease Tangier Disease Neuropathy Familial Alpha-Lipoprotein Deficiency Familial High-Density Lipoprotein Deficiency 1 Primary Hypoalphalipoproteinemia 1 Analphalipo-Proteinemia Familial Hypoalphalipo-Proteinemia Familial Hypoalphalipoproteinemia Lipoprotein Deficiency Disease, Hdl, Familial Tangier Hereditary Neuropathy Atp-Binding Cassette Transporter A1 Deficiency Hdld1 High Density Lipoprotein Deficiency 1 Tangier Disease, Variant Hypoalphalipoproteinemia, Familial Familial Hdl Deficiency
Amyloidosis, Familial Visceral	Ostertag Type Amyloidosis German Type Amyloidosis Familial Renal Amyloidosis Amyloidosis Viii Amyloidosis, 3 Or More Types Familial Visceral Amyloidosis Familial Amyloid Nephropathy Hereditary Amyloid Nephropathy Amyloidosis, Familial Renal Amyloidosis, Systemic Nonneuropathic Amyloidosis Familial Visceral Amyloidosis 8 Amyloidosis, Ostertag Type Hereditary Amyloidosis With Primary Renal Involvement Hereditary Renal Amyloidosis Renal Amyloidosis Amyloidosis, Renal Systemic Nonneuropathic Amyloidosis Amyloidosis Familial Renal Amyloidosis Systemic Nonneuropathic Hereditary Amyloidosis With Primary Renal Involement AMYL8 Systemic Non-Neuropathic Amyloidosis Amyloid Nephropathy
Hypoalphalipoproteinemia
Familial Hyperlipidemia	Familial Hyperlipoproteinemia Hyperlipidaemia Hyperlipoproteinemias Hyperlipidemia Hyperlipemia Hyperlipidemias
Carotid Artery Disease	Carotid Artery Diseases Disorder Of Carotid Artery
Amyloidosis	Amyloid Disease Amyloid Amyloid Degeneration Amyloidosis Nos Amyloid Deposition Amyloid Infiltration Idiopathic Amyloidosis Hyaloid Degeneration Lardaceous Degeneration
Hypertriglyceridemia 1	Hypertriglyceridemia Hypertriglyceridemia, Familial Hypertriglyceridemia, Susceptibility To HYTG1 FHTR Hypertriglyceridemias Familial
Apolipoprotein A-Iv Associated Amyloidosis	Aapoaiv Amyloidosis Renal Aapoaiv Amyloidosis Apolipoprotein A-Iv Amyloidosis
Hyperlipidemia, Familial Combined, 3	Familial Combined Hyperlipidemia Combined Hyperlipidemia, Familial Mixed Hyperlipidaemia FCHL3 Hyperlipidemia, Familial Combined Familial Multiple Lipoprotein-Type Hyperlipidemia Hyperbetalipoproteinemia With Prebetalipoproteinemia Type Iib Hyperlipoproteinemia Hyperlipidemia Familial Combined Hyperlipoproteinemia Type Iib Mixed Hyperlipemia Hyperlipidaemia, Group C Familial Hypercholesterolaemia With Hyperlipaemia Familial Hyperbetalipoproteinaemia And Hyperprebetalipoproteinaemia Hyperbetalipoproteinaemia With Prebetalipoproteinaemia Hypercholesterolaemia With Endogenous Hyperglyceridaemia Prebetalipoproteinemia Hyperbetalipoproteinaemia Remnant Hyperlipoproteinemia
Hypoalphalipoproteinemia, Primary, 2	Apolipoprotein A-I Deficiency Hypoalphalipoproteinemia, Primary, 2, Autosomal Recessive Primary Hypoalphalipoproteinemia 2 High Density Lipoprotein Deficiency Apoa-I Deficiency Familial Apoa-I Deficiency Familial Hypoalphalipoproteinemia FHA2 Apolipoprotein A-I
Thrombophilia Due To Hrg Deficiency	Hereditary Thrombophilia Due To Congenital Histidine-Rich Glycoprotein Deficiency Hereditary Thrombophilia Due To Congenital Hrg Deficiency Thph11
Immunoglobulin Heavy-And-Light Chain	Ah/Al Amyloidosis Ig Heavy-And-Light-Chain Amyloidosis
Polyneuropathy	Polyneuropathies
Hypolipoproteinemia	Hypolipoproteinaemia Lipoprotein Deficiencies Lipoprotein Disorder Hypolipoproteinemias Lipoprotein Lipoprotein Deficiency Hypolipidaemia Lipoprotein Deficiency Disorder High-Density Lipoid Deficiency High-Density Lipoprotein Deficiency Dyslipidaemia, Depressed Hdl Cholesterol
Hypoalphalipoproteinemia, Primary, 1	Familial Hdl Deficiency Fha High Density Lipoprotein Deficiency Familial Hypoalphalipoproteinemia Hypoalphalipoproteinemia, Familial Hdld Fhd Hdl Deficiency, Type 2 Primary Hypoalphalipoproteinemia 1 Hdl Cholesterol, Low Serum Hdlc Hdl Deficiency, Familial, 1 Hypoalphalipoproteinemia, Primary Low Serum Hdl Cholesterol Primary Hypoalphalipoproteinemia FHA1 Hdld2 High Density Lipoprotein Deficiency 2 Hypoalphalipoproteinemias Apolipoprotein A-I Deficiency
Atherosclerosis Susceptibility	Atherosclerosis Atherosclerosis, Susceptibility To ATHS Atherogenic Lipoprotein Phenotype Alp Arteriosclerosis
Lipid Metabolism Disorder	Dyslipidemia Disorder Of Fatty Acid Metabolism Lipid Metabolism Disorders Fatty Acid Metabolism Disorder Disorder Of Lipid Metabolism Abnormality Of Lipid Metabolism Lipid Metabolism, Inborn Errors Dyslipidemias Disorders Of Lipid Metabolism Congenital Disorders Of Lipid Metabolism Inherited Disorders Of Lipid Metabolism
Dialysis-Related Amyloidosis	Abeta2m Amyloidosis Amyloidosis Beta2m Beta2-Microglobulinic Amyloidosis Variant Abeta2m Amyloidosis Autosomal Dominant Beta2-Microglobulinic Amyloidosis Aβ2m Amyloidosis Dialysis-Related Beta2-Microglobulin Amyloidosis Amyloidosis Dialysis-Related Beta-2-Microglobulin Amyloidosis Dra Hemodialysis-Associated Amyloidosis
Type 1 Diabetes Mellitus 6	Diabetes Mellitus, Insulin-Dependent, 6 Iddm6 Insulin-Dependent Diabetes Mellitus 6 T1D6 Insulin-Dependent Diabetes Mellitus-6
Immunoglobulin Heavy Chain Amyloidosis	Ah Amyloidosis Heavy Chain Amyloidosis Amyloidosis Derived From Immunoglobulin Heavy Chain Ig Heavy-Chain-Associated Amyloidosis
Wild-Type Amyloidosis	Senile Systemic Amyloidosis Attrwt Amyloidosis Age Related Amyloidosis Old Age Amyloidosis Wild-Type Attr Amyloidosis Wild-Type Transthyretin Cardiac Amyloidosis Wild Type Attr Amyloidosis Attrwt-Related Amyloidosis Wild Type Attr-Related Amyloidosis
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Type 2 Diabetes Diabetes Mellitus, Non-Insulin-Dependent T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes
Amyloidosis, Hereditary, Transthyretin-Related	Transthyretin Amyloidosis Familial Amyloid Polyneuropathy Ttr Amyloid Neuropathy Transthyretin Amyloid Neuropathy Transthyretin Amyloid Polyneuropathy Fap Familial Transthyretin Amyloidosis Amyloidosis Transthyretin Related Type I Familial Amyloid Polyneuropathy Familial Amyloid Polyneuropathy Type I Attrv122i Amyloidosis Hereditary Amyloidosis, Transthyretin-Related Amyloid Polyneuropathy, Familial Attr Amyloidosis Attrm Amyloidosis Corino De Andrade'S Disease Paramyloidosis Transthyretin-Related Hereditary Amyloidosis Ttr Amyloidosis Hereditary Attr Amyloidosis Portuguese Polyneuritic Amyloidosis Portuguese Type Familial Amyloid Neuropathy Swiss Type Amyloid Polyneuropathy Type Ii Familial Amyloid Polyneuropathy Attrv30m Amyloidosis Attrv30m-Related Amyloidosis Familial Amyloid Polyneuropathy, Portuguese-Swedish-Japanese Type Attr Cardiomyopathy Attrv122i-Related Amyloidosis Ttr-Related Amyloid Cardiomyopathy Ttr-Related Cardiac Amyloidosis Transthyretin Amyloid Cardiopathy Transthyretin-Related Familial Amyloid Cardiomyopathy Amyloidosis, Transthyretin-Related AMYL-TTR Amyloidosis I Amyloidosis Ohio Type Amyloidosis Type 7 Amyloidosis Vii Amyloid Polyneuropathy Attr Familial Amyloid Polyneuropathy Type Ii Hereditary Amyloidosis Transthyretin-Related Leptomeningeal Amyloidosis Meningocerebrovascular Amyloidosis Oculoleptomeningeal Amyloidosis Familial Amyloid Polyneuropathies Amyloidosis, Leptomeningeal Senile Cardiac Amyloidosis Amyloid Neuropathies, Familial Danish Type Familial Amyloid Cardiomyopathy Familial Amyloid Neuropathy, Portuguese Type Amyloid Polyneuropathy, Swiss Type Hereditary Oculoleptomeningeal Amyloid Angiopathy Amyloid Neuropathies
Lipoprotein Quantitative Trait Locus	Coronary Artery Disease Coronary Artery Anomaly Coronary Artery Disease, Susceptibility To Myocardial Ischemia Congenital Anomaly Of Coronary Artery Coronary Arteriosclerosis Coronary Disease Coronary Heart Disease Coronary Artery Disorder LPAQTL Lpa Deficiency, Congenital Coronary Artery Abnormality Coronary Artery Anomaly, Congenital Chd Coronary Syndrome Congenital Malformations Of Coronary Vessels Malformation Of Coronary Vessels Congenital Coronary Artery Anomaly Congenital Coronary Artery Deformity Congenital Coronary Artery Disorder Abnormal Coronary Artery Congenital Coronary Artery Malposition Congenital Coronary Disease Congenital Anomaly Of Coronary Arteries
Immunoglobulin Light Chain Amyloidosis	Al Amyloidosis Primary Amyloidosis Primary Systemic Amyloidosis Light Chain Amyloidosis Amyloidosis Al Amyloidosis Primary Systemic Primary Al Amyloidosis Primary Systemic Al Amyloidosis Systemic Al Amyloidsis Systemic Al Amyloidosis Light-Chain Amyloidosis Alys Amyloidosis Familial Amyloid Nephropathy Due To Lysozyme Variant Familial Renal Amyloidosis Due To Lysozyme Variant Hereditary Amyloid Nephropathy Due To Lysozyme Variant Hereditary Renal Amyloidosis Due To Lysozyme Variant Lysozyme Amyloidosis Amyloidosis Primary Immunoglobulin Deposition Disease Immunoglobulinic Amyloidosis Amyloid Al
Vascular Disease	Vascular Diseases Aneurysm Spinal Cord Ischemia Vascular Anomaly Spinal Cord Vascular Diseases Vascular Tissue Disease
Myocardial Infarction	Heart Attack Myocardial Infarction, Susceptibility To Myocardial Infarction 1 Myocardial Infarction, Protection Against Myocardial Infarction, Decreased Susceptibility To Myocardial Infarction, Decreased Myocardial Infarct MCI1 Premature Myocardial Infarction Myocardial Infarction, Susceptibility To, Type 1
Coronary Heart Disease 1	Coronary Heart Disease Coronary Heart Disease, Susceptibility To, 1 Chds1 Coronary Heart Disease, Susceptibility To CHD Heart, Coronary, Disease, Susceptibility To, Type 1 Coronary Arteriosclerosis Coronary Artery Disease
Aortic Atherosclerosis	Atherosclerosis Of Aorta Aorta Atheroma Aorta Calcification Aorta Arteriosclerosis Aortic Degeneration Aortic Calcification Aortic Atheroma Aortic Arteriosclerotic Disease Aortic Arteriosclerosis Aorta Sclerosis Aorta Degeneration Atheromatous Aortic Calcified Aortic Stenosis Atheromatous Aorta Arteriosclerotic Aortitis Arteriosclerotic Aortic Stenosis Arteriosclerotic Aorta Disease Aortic Sclerosis
Heart Disease	Heart Failure Congenital Heart Disease Heart Diseases Congenital Heart Defects Congenital Heart Defect Heart Malformation Congenital Anomaly Of Heart Heart Defect Heart-Congenital Defect Congenital Heart Disorder Heart Defects Congenital Heart Defects, Congenital Heart Defects Heart Disease, Congenital Disease, Heart, Congenital Congestive Heart Failure
Diabetes Mellitus	Diabetes
Cardiovascular System Disease	Abnormality Of The Cardiovascular System Cardiovascular Disease Disease Of Subdivision Of Hemolymphoid System Disorder Of Cardiovascular System Cardiovascular Diseases
Body Mass Index Quantitative Trait Locus 11	OBESITY Obesity, Susceptibility To Leanness, Inherited Obesity, Susceptibility To, Bmiq11 Obesity, Mild, Early-Onset Obesity, Association With Obesity, Early-Onset, Susceptibility To Obesity, Severe Obesity, Severe, And Type Ii Diabetes Obesity, Late-Onset Obesity , Susceptibility To BMIQ11 Obesity Bmiq11 Obesity, Early-Onset Simple Obesity Nos Excess Fat Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified Adiposis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS19983	Apoa2 Mouse Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	APOA2	VGNC	VGNC:26023
Rattus norvegicus	APOA2	RGD	RGD:2131
Mus musculus	APOA2	MGD	MGI:88050
Canis familiaris	APOA2	VGNC	VGNC:37992
Macaca mulatta	APOA2	VGNC	VGNC:99846
Others	APOA2	NCBI