Aqp1 - aquaporin 1 Gene

Also Known as CHIP28

Species: Mus musculus

Gene Type: protein coding
Gene ID: 11826

Summary

Enables Ephrin Receptor binding activity; potassium ion transmembrane transporter activity; and water transmembrane transporter activity. Involved in defense response to Gram-negative bacterium and potassium ion transport. Acts upstream of or within several processes, including corticotropin secretion; glomerular filtration; and metanephros development. Located in several cellular components, including basolateral plasma membrane; extracellular exosome; and symbiont-containing vacuole. Is integral component of membrane. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; sensory organ; and skeleton. Orthologous to human AQP1 (Aquaporin 1 (Colton blood group)). [provided by Alliance of Genome Resources, Apr 2022]

Aqp1 Products (1)

mRNA Protein Name
NM_007472.2 NP_031498.1 aquaporin-1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ephrin receptor binding IPI
IPI: Inferred from physical interaction
10839360 MGI
enables potassium ion transmembrane transporter activity IDA
IDA: Inferred from direct assay
18665841 MGI
enables water transmembrane transporter activity IDA
IDA: Inferred from direct assay
10644730 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within camera-type eye morphogenesis IMP
IMP: Inferred from mutant phenotype
11891232 MGI
acts upstream of cell migration IMP
IMP: Inferred from mutant phenotype
19298815 MGI
acts upstream of or within corticotropin secretion IMP
IMP: Inferred from mutant phenotype
18511498 MGI
involved in defense response to Gram-negative bacterium IMP
IMP: Inferred from mutant phenotype
18665841 MGI
acts upstream of or within establishment of localization in cell IGI
IGI: Inferred from genetic interaction
12133842 MGI
acts upstream of or within establishment of localization in cell IMP
IMP: Inferred from mutant phenotype
10613915 MGI
acts upstream of fibroblast migration IMP
IMP: Inferred from mutant phenotype
19298815 MGI
acts upstream of or within glomerular filtration IMP
IMP: Inferred from mutant phenotype
15283758 MGI
involved in lateral ventricle development IEP
IEP: Inferred from expression pattern
16133142 MGI
acts upstream of or within lipid digestion IMP
IMP: Inferred from mutant phenotype
11121384 MGI
involved in metanephric descending thin limb development IEP
IEP: Inferred from expression pattern
18618131 MGI
involved in metanephric glomerulus vasculature development IEP
IEP: Inferred from expression pattern
18618131 MGI
involved in metanephric proximal convoluted tubule segment 2 development IEP
IEP: Inferred from expression pattern
18618131 MGI
involved in metanephric proximal straight tubule development IEP
IEP: Inferred from expression pattern
18618131 MGI
acts upstream of or within multicellular organismal-level water homeostasis IMP
IMP: Inferred from mutant phenotype
12034763 MGI
acts upstream of or within positive regulation of fibroblast migration IMP
IMP: Inferred from mutant phenotype
19298815 MGI
involved in potassium ion transport IDA
IDA: Inferred from direct assay
18665841 MGI
acts upstream of or within renal water absorption IGI
IGI: Inferred from genetic interaction
10662735 MGI
acts upstream of or within renal water absorption IMP
IMP: Inferred from mutant phenotype
9468475 MGI
acts upstream of or within secretion by cell IMP
IMP: Inferred from mutant phenotype
18511498 MGI
acts upstream of or within secretory granule organization IMP
IMP: Inferred from mutant phenotype
18511498 MGI
acts upstream of or within sensory perception of pain IMP
IMP: Inferred from mutant phenotype
16476579 MGI
acts upstream of or within water transport IDA
IDA: Inferred from direct assay
10644730 MGI
acts upstream of or within water transport IGI
IGI: Inferred from genetic interaction
12133842 MGI
acts upstream of or within water transport IMP
IMP: Inferred from mutant phenotype
9886922 MGI
acts upstream of or within wound healing IMP
IMP: Inferred from mutant phenotype
19298815 MGI
Cellular Component GO Annotation Evidence References Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
16133142 MGI
located in axon IDA
IDA: Inferred from direct assay
17257750 MGI
located in basal plasma membrane IDA
IDA: Inferred from direct assay
23238222 MGI
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
16133142 MGI
located in brush border IDA
IDA: Inferred from direct assay
16133142 MGI
located in caveola IDA
IDA: Inferred from direct assay
23238222 MGI
located in extracellular exosome IDA
IDA: Inferred from direct assay
19724054 MGI
located in membrane IDA
IDA: Inferred from direct assay
12181190 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
11078688 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

aquaporin-1

  • AQP-1

  • DER2

  • aquaporin-CHIP

  • delayed early response protein 2

  • growth factor-induced delayed early response protein

  • water channel protein for red blood cells and kidney proximal tubule

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N6016 Bacopaside II 98.86% Unkown
HY-110200 TC AQP1 1 Inhibitor 98.03% Unkown
HY-N2013 Aristolactam I 99.44% Unkown
HY-174166 AqF026 Activator 99.05% Unkown
HY-N4246 Bacopaside I 99.20% Unkown
HY-RS00871 AQP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17735 Aqp1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24200 Aqp1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Aqp1 NCBI NCBI:358