Serpinc1 - serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1 Gene

Also Known as At3; At-3; ATIII

Species: Mus musculus

Gene Type: protein coding
Gene ID: 11905

Summary

Predicted to enable several functions, including heparin binding activity; identical protein binding activity; and serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of endopeptidase activity and response to nutrient. Predicted to act upstream of or within blood coagulation and negative regulation of peptidase activity. Located in collagen-containing extracellular matrix. Is expressed in embryo; liver; neural tube; and notochord. Used to study Antithrombin III deficiency. Human ortholog(s) of this gene implicated in Antithrombin III deficiency; disseminated intravascular coagulation; intermediate coronary syndrome; thrombosis; and toxic shock syndrome. Orthologous to human SERPINC1 (Serpin family C member 1). [provided by Alliance of Genome Resources, Apr 2022]

Serpinc1 Products (2)

mRNA Protein Name
NM_001379302.1 NP_001366231.1 antithrombin-III isoform 2
NM_080844.5 NP_543120.1 antithrombin-III isoform 1 precursor
Protein Preferred Names Protein Names

antithrombin-III

  • anti-thrombin 3

  • antithrombin

  • serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1

  • serpin C1

  • serpin peptidase inhibitor, clade C, member 1

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-132587 Fitusiran 94.74% Unkown
HY-132587A Fitusiran sodium 95.08% Unkown
HY-132587C Fitusiran sodium scrambled negative control Activator / Unkown
HY-132587D FAM labled Fitusiran sodium / Unkown
HY-132587E Cy3 labled Fitusiran sodium / Unkown

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12718 SERPINC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18212 Serpinc1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24689 Serpinc1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Serpinc1 NCBI NCBI:462