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Anxa2 - annexin A2 Gene

Also Known as p36; Cal1h; PAP-IV

Species: Mus musculus

Gene Type: protein coding

Gene ID: 12306

Summary

Predicted to enable several functions, including enzyme binding activity; enzyme inhibitor activity; and phospholipid binding activity. Involved in several processes, including negative regulation of low-density lipoprotein particle receptor catabolic process; positive regulation of low-density lipoprotein particle clearance; and positive regulation of low-density lipoprotein particle receptor binding activity. Acts upstream of or within several processes, including angiogenesis; Collagen fibril organization; and fibrinolysis. Located in several cellular components, including Schmidt-Lanterman incisure; basolateral plasma membrane; and myelin sheath adaxonal region. Is extrinsic component of plasma membrane. Is expressed in several structures, including central nervous system; dorsal aorta; oral epithelium; primary palate; and yolk sac blood vessel. Human ortholog(s) of this gene implicated in osteonecrosis. Orthologous to several human genes including AnxA2 (annexin A2). [provided by Alliance of Genome Resources, Apr 2022]

Anxa2 Products (2)

mRNA	Protein	Name
NM_001409577.1	NP_001396506.1	annexin A2
NM_007585.4	NP_031611.1	annexin A2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	14506282	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within angiogenesis	IMP IMP: Inferred from mutant phenotype	14702107	MGI
acts upstream of or within cell adhesion	IMP IMP: Inferred from mutant phenotype	24357721	MGI
acts upstream of or within cell-matrix adhesion	IMP IMP: Inferred from mutant phenotype	24357721	MGI
acts upstream of or within cellular response to acid chemical	IDA IDA: Inferred from direct assay	17690254	MGI
acts upstream of or within collagen fibril organization	IMP IMP: Inferred from mutant phenotype	14702107	MGI
acts upstream of or within epithelial cell apoptotic process	IMP IMP: Inferred from mutant phenotype	24357721	MGI
acts upstream of or within fibrinolysis	IMP IMP: Inferred from mutant phenotype	14702107	MGI
acts upstream of or within lung development	IMP IMP: Inferred from mutant phenotype	24357721	MGI
involved in mRNA transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	23415230	MGI
involved in negative regulation of low-density lipoprotein particle receptor catabolic process	IMP IMP: Inferred from mutant phenotype	22848640	MGI
acts upstream of or within positive regulation of binding	IMP IMP: Inferred from mutant phenotype	17690254	MGI
involved in positive regulation of low-density lipoprotein particle clearance	IMP IMP: Inferred from mutant phenotype	22848640	MGI
involved in positive regulation of low-density lipoprotein particle receptor binding	IMP IMP: Inferred from mutant phenotype	22848640	MGI
involved in positive regulation of low-density lipoprotein receptor activity	IMP IMP: Inferred from mutant phenotype	22848640	MGI
involved in positive regulation of receptor recycling	IMP IMP: Inferred from mutant phenotype	22848640	MGI
involved in positive regulation of receptor-mediated endocytosis involved in cholesterol transport	IMP IMP: Inferred from mutant phenotype	22848640	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	23415230	MGI
involved in regulation of neurogenesis	IDA IDA: Inferred from direct assay	23415230	MGI
acts upstream of or within response to activity	IMP IMP: Inferred from mutant phenotype	24357721	MGI

Cellular Component GO Annotation	Evidence	References	Source
part of RNA polymerase II transcription regulator complex	IPI IPI: Inferred from physical interaction	23415230	MGI
located in Schmidt-Lanterman incisure	IDA IDA: Inferred from direct assay	20237282	MGI
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	22848640	MGI
located in cell surface	IDA IDA: Inferred from direct assay	17690254	MGI
is active in cornified envelope	IDA IDA: Inferred from direct assay	26644517	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	15078881	MGI
located in cytosol	IDA IDA: Inferred from direct assay	16731532	MGI
located in early endosome	IDA IDA: Inferred from direct assay	15078881	MGI
located in myelin sheath adaxonal region	IDA IDA: Inferred from direct assay	20237282	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	3126079	MGI
part of plasma membrane protein complex	EXP EXP: Inferred from Experiment	23415230	MGI
part of plasma membrane protein complex	IPI IPI: Inferred from physical interaction	23415230	MGI
located in sarcolemma	IDA IDA: Inferred from direct assay	14506282	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
annexin A2	33-kDa calcimedin 33-kDa lymphocyte Ca- binding protein 33kDa lymphocyte Ca- binding protein 36-kDa calelectrin annexin II annexin-2 calpactin I heavy chain calpactin-1 heavy chain chromobindin-8 lipocortin II placental anticoagulant protein IV

Recombinant Anxa2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77561	Annexin A2/ANXA2 Protein, Mouse (His)	P07356 (S2-D339)	≥ 95%, as determined by Bis-Tris PAGE.

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-141644	PY-60	Activator	99.42%	Unkown
HY-P2333	LCKLSL	Inhibitor	99.26%	Unkown
HY-P2333A	LCKLSL hydrochloride	Inhibitor	98.05%	Unkown
HY-169212	I194496	Inhibitor	98.52%	Unkown
HY-RS00761	ANXA2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16855	Anxa2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-176548	PY-PAP		/	Unkown
HY-RS00762	ANXA2R Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23296	Anxa2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Anxa2	NCBI	NCBI:302