Calr - calreticulin Gene

Also Known as CRT; Calregulin

Species: Mus musculus

Gene Type: protein coding

Gene ID: 12317

Summary

Enables calcium ion binding activity; carbohydrate binding activity; and mRNA binding activity. Involved in several processes, including cellular senescence; peptide antigen assembly with MHC class I protein complex; and protein stabilization. Acts upstream of or within cortical actin Cytoskeleton organization; positive regulation of NIK/NF-kappaB signaling; and regulation of meiotic nuclear division. Located in endoplasmic reticulum; external side of plasma membrane; and extracellular space. Part of MHC class I peptide loading complex. Is expressed in several structures, including central nervous system; extraembryonic component; gut; placenta; and spleen. Used to study congestive heart failure. Human ortholog(s) of this gene implicated in essential thrombocythemia; myelofibrosis; pancreatic ductal adenocarcinoma; sideroblastic anemia; and thrombocytosis. Orthologous to human CALR (calreticulin). [provided by Alliance of Genome Resources, Apr 2022]

Calr Products (1)

mRNA	Protein	Name
NM_007591.3	NP_031617.1	calreticulin precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables calcium ion binding	IDA IDA: Inferred from direct assay	3513762	MGI
enables carbohydrate binding	IDA IDA: Inferred from direct assay	20880849	MGI
enables mRNA binding	IDA IDA: Inferred from direct assay	14726956	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	17934213	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in cellular senescence	IMP IMP: Inferred from mutant phenotype	14726956	MGI
acts upstream of or within cortical actin cytoskeleton organization	IDA IDA: Inferred from direct assay	15136153	MGI
involved in peptide antigen assembly with MHC class I protein complex	IMP IMP: Inferred from mutant phenotype	11825569	MGI
involved in positive regulation of cell cycle	IMP IMP: Inferred from mutant phenotype	14726956	MGI
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	15998798	MGI
acts upstream of or within positive regulation of non-canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	24998604	MGI
involved in positive regulation of phagocytosis	IMP IMP: Inferred from mutant phenotype	17187072	MGI
involved in protein localization to nucleus	IMP IMP: Inferred from mutant phenotype	15998798	MGI
involved in protein stabilization	IDA IDA: Inferred from direct assay	21652723	MGI
acts upstream of or within regulation of meiotic nuclear division	IDA IDA: Inferred from direct assay	15136153	MGI

Cellular Component GO Annotation	Evidence	References	Source
part of MHC class I peptide loading complex	IMP IMP: Inferred from mutant phenotype	11825569	MGI
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	12676993	MGI
located in endoplasmic reticulum lumen	IDA IDA: Inferred from direct assay	21187406	MGI
located in endoplasmic reticulum quality control compartment	IDA IDA: Inferred from direct assay	11408579	MGI
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	15136153	MGI
located in extracellular space	IDA IDA: Inferred from direct assay	15136153	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
calreticulin	CRP55 ERp60 HACBP endoplasmic reticulum resident protein 60

Recombinant Calr Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72112	Calreticulin/CALR Protein, Mouse (GST)	P14211 (D18-L416)	≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-109113	Camsirubicin	Inhibitor	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-14307	Necrocide 1		99.55%	Unkown
HY-176252	CALR ligand 1	Inducer	/	Unkown
HY-RS01847	CALR Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS01848	CALR3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17947	Calr Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20371	Calr3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24418	Calr Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26881	Calr3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Calr	NCBI	NCBI:811