Car4 - carbonic anhydrase 4 Gene

Also Known as Ca4

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12351

About Car4

Chromosome 11: 84,848,612-84,856,870 forward strand.GRCm39:CM001004.3

This gene has 6 transcripts (splice variants), 333 orthologues, 15 paralogues and is associated with 9 phenotypes. Biased expression in colon adult (RPKM 148.4), placenta adult (RPKM 86.4) and 1 other tissues.

Summary

Enables carbonate dehydratase activity. Predicted to be involved in bicarbonate transport and one-carbon metabolic process. Predicted to act upstream of or within carbon dioxide transport and regulation of pH. Located in membrane. Is anchored component of plasma membrane. Is expressed in cardiovascular system; genitourinary system; nervous system; and tail. Human ortholog(s) of this gene implicated in retinitis pigmentosa. Orthologous to human CA4 (Carbonic Anhydrase 4). [provided by Alliance of Genome Resources, Apr 2022]

Car4 Products (1)

mRNA Protein Name
NM_007607.2 NP_031633.1 carbonic anhydrase 4 precursor

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables carbonate dehydratase activity IDA
IDA: Inferred from direct assay
14660577 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
14567693 MGI
Cellular Component GO Annotation Evidence References Source
located in membrane IDA
IDA: Inferred from direct assay
16083424 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
16083424 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Car4 Protein Structure

alpha_CA_IV_XV_like

alpha_CA_IV_XV_like: cd03117 (47 - 275)

  • 0
  • 100
  • 200
  • 305 a.a.
Protein Preferred Names Protein Names

carbonic anhydrase 4

  • CA-IV

  • carbonate dehydratase IV

  • carbonic anhydrase IV

Car4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Ca4 Q64444 Slc4a4 Mus musculus O88343
Anti Bait CoIP
14567693
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant Car4 Proteins

Cat. No. Product Name Accession Purity
HY-P7717 Carbonic Anhydrase 4 Protein, Mouse (HEK293, His) Q64444 (E18-S277) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01770 CA4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01911 Car4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01912 Car4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown