Slc4a4 - solute carrier family 4 (anion exchanger), member 4 Gene

Also Known as NBC; NBC1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 54403

Summary

Predicted to enable identical protein binding activity and sodium:bicarbonate symporter activity. Involved in regulation of intracellular pH. Acts upstream of or within bicarbonate transport and sodium ion transport. Predicted to be located in cell surface and membrane. Predicted to be active in basolateral plasma membrane. Is expressed in several structures, including brain; metanephros; spinal cord floor plate; and thyroid primordium. Used to study renal tubular acidosis. Human ortholog(s) of this gene implicated in renal tubular acidosis. Orthologous to human SLC4A4 (solute carrier family 4 member 4). [provided by Alliance of Genome Resources, Apr 2022]

Slc4a4 Products (6)

mRNA Protein Name
NM_001136260.1 NP_001129732.1 electrogenic sodium bicarbonate cotransporter 1 isoform b
NM_001197147.1 NP_001184076.1 electrogenic sodium bicarbonate cotransporter 1 isoform c
NM_001359211.1 NP_001346140.1 electrogenic sodium bicarbonate cotransporter 1 isoform d
NM_001359212.1 NP_001346141.1 electrogenic sodium bicarbonate cotransporter 1 isoform e
NM_001359213.1 NP_001346142.1 electrogenic sodium bicarbonate cotransporter 1 isoform f
NM_018760.2 NP_061230.2 electrogenic sodium bicarbonate cotransporter 1 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
14567693 MGI
enables sodium:bicarbonate symporter activity IDA
IDA: Inferred from direct assay
11171615 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within bicarbonate transport IGI
IGI: Inferred from genetic interaction
19033647 MGI
acts upstream of or within establishment of localization in cell IGI
IGI: Inferred from genetic interaction
19033647 MGI
acts upstream of positive regulation of glycolytic process IMP
IMP: Inferred from mutant phenotype
21976511 MGI
acts upstream of regulation of intracellular pH IMP
IMP: Inferred from mutant phenotype
21976511 MGI
involved in regulation of intracellular pH IMP
IMP: Inferred from mutant phenotype
24453308 MGI
acts upstream of regulation of membrane potential IMP
IMP: Inferred from mutant phenotype
21976511 MGI
acts upstream of or within sodium ion transport IDA
IDA: Inferred from direct assay
9651366 MGI
Cellular Component GO Annotation Evidence References Source
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
11171615 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

electrogenic sodium bicarbonate cotransporter 1

  • Na(+)/HCO3(-) cotransporter

  • pancreas sodium bicarbonate cotransporter

  • sodium bicarbonate cotransporter

  • solute carrier family 4 member 4

  • solute carrier family 4, sodium bicarbonate cotransporter, member 4

Slc4a4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Slc4a4 O88343 Ca4 Mus musculus Q64444
Anti Bait CoIP
14567693
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS19074 Slc4a4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13270 SLC4A4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25564 Slc4a4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc4a4 NCBI NCBI:8671